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Biomarcadores no diagnóstico da doença renal em cães / Biomarkers in the diagnosis of renal disease in dogsSouza, Saura Nayane de 06 March 2017 (has links)
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Previous issue date: 2017-03-06 / The goal of the study was to evaluate cystatin C and other biomarkers as diagnostic
tools in canine renal disease. The project was divided in two studies. In the first study
renal injury was induced in 6 animals by subcutaneous administration of gentamicin
(30mg/kg) for 10 days, and 6 animals were kept as controls. Animals were evaluated
for 45 days by the following clinical and laboratorial parameters: physical
examination; hemogram and fibrinogen levels; measurement of creatinine, urea,
total proteins, albumin, phosphorus, calcium, sodium, potassium, cholesterol levels
(biochemical analysis); serum protein electrophoresis; urine sodium, potassium,
gamma glutamyl transferase and alkaline phosphatase levels; urinalysis; urine
protein / creatinine ratio; hemogasometry and non-invasive systemic arterial
pressure. The second study evaluated the level of cystatin C in 58 dogs suffering from
different stages (2-4) of chronical renal disease, as defined by International Renal
Interest Society (IRIS) guidelines. Six animals presenting acute renal injury induced bygentamicin treatment were also evaluated (for 20 time points upon injury). The
results indicated that changes in urine gamma glutamyl transferase and fractional
excretion of sodium and potassium were the earliest parameters indicating acute
renal injury, even when compared to most common renal disease biomarkers: urea
and creatinine. Cystatin C measurement, on the other hand, showed little value for
early detection of chronic kidney disease and acute kidney injury in dogs. / O objetivo deste estudo foi avaliar a aplicação dos biomarcadores, em especial da
cistatina C, no diagnóstico da doença renal em cães e compreendeu duas etapas.
Uma fase constou da avaliação de 12 cães, sendo seis pertencentes ao grupo
controle e seis cães pertencentes ao grupo experimental que foram submetidos a
um protocolo de indução de injúria renal com 30 mg/kg ao dia de gentamicina, via
subcutânea, durante 10 dias. Os cães foram avaliados durante 45 dias por meio de:
exame clínico; hemograma e fibrinogênio; bioquímica sérica (ureia, creatinina,
proteínas totais, albumina, fósforo, cálcio, sódio, potássio, colesterol e eletroforese
das proteínas séricas); bioquímica urinária (sódio, potássio, gama glutamil
transferase e fosfatase alcalina); urinálise; determinação da razão
proteína/creatinina urinária; hemogasometria e pressão arterial sistólica não-
invasiva. A outra fase constou da mensuração da cistatina C sérica em 58 cães com
doença renal crônica divididos nos estádios 2, 3 e 4 da IRIS (International Renal
Interest Society) e em seis cães com injúria renal aguda induzida por gentamicina,
avaliados durante 20 momentos após o início da injúria. Os resultados
demonstraram que a enzima gama glutamil transferase urinária e a excreção
fracionada de sódio e potássio foram mais precoces em detectar a injúria renal aguda
em cães do que outros marcadores mais utilizados na rotina clínica como a creatinina
e a ureia. A cistatina C sérica não foi eficiente em detectar de forma precoce a doença
renal crônica em cães nos estádios iniciais e a injúria renal aguda, possuindo uma
baixa aplicabilidade neste estudo.
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Prieširdžių virpėjimo po miokardo revaskuliarizacijos operacijų sąsaja su elektrolitų koncentracija serume bei ekskrecija su šlapimu / Relation of postoperative atrial fibrillation to serum electrolyte concentration and urinary electrolyte excretion after myocardial revascularizationŠvagždienė, Milda 19 December 2006 (has links)
Postoperative atrial fibrillation (AF) after cardiac surgery with cardiopulmonary bypass (CPB) remains unresolved problem. Some authors noticed that there were changes in electrolyte balance after coronary artery bypass grafting (CABG) surgery with CPB. The changes in serum magnesium level and their relation with the rate of postoperative AF are usually analyzed in scientific publications. The aim of the study has been to estimate the relationship between the rate of postoperative AF and the changes in serum electrolyte concentration and their urinary excretion after CABG surgery with CPB. The goals: 1) To estimate the rate and the character of postoperative AF and its influence on haemodynamics after CABG surgery. 2) To estimate changes in serum K+, Na+, Mg++, Ca++, Cl–, P– concentration and compare them between the patients who received, and who did not receive magnesium sulphate supplementation during the surgery. 3)To estimate changes of urinary excretion of K+, Na+, Mg++, Ca++, Cl–, P– and compare them between the patients who received, and who did not receive magnesium sulphate supplementation during the surgery. 3) To evaluate the effects of intraoperatively infused magnesium sulphate on the rate of postoperative AF in the early postoperative period.
In our study the rate of postoperative AF was 27.4 %. AF in 91.3 % of cases was tachyarrhythmic, but haemodynamic remained stabile. Serum Mg++ level was > 1.05 mmol/l during the suregry in all patients. The infusion of... [to full text]
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