Purpose: Previous clinical studies have suggested a positive effect of low-frequency pulsed electromagnetic fields (PEMF) on wound healing and inflammation in the eye. We tried to test the value of PEMF treatment in a hyphema animal model with well-defined conditions. Methods: After injection of citrated autologous blood for the production of hyphema, 16 rabbit eyes were treated with 10 or 20 mT for 60 min on 4 days within the postoperative week. Two control groups with hyphema alone (n = 8) and PEMF irradiation without hyphema (n = 4) were also included. The rate of resorption was recorded daily. Histopathologic evaluation was performed. Results: The incidence of endothelial cell damage and fibrotic clots was markedly reduced in the 10-mT group while the resorption time of 8 days was identical with the control group. In the 20-mT group, the complication rate and the resorption time was increased versus the control group. Conclusions: The use of PEMF treatment is of some, however, limited value as it did not reduce the resorption time of hyphema but displayed a dose-dependent, beneficial influence on some serious side effects. Future clinical studies with low-dose PEMF irradiation are justified and should determine the optimal dosage and suitable indications of PEMFs as an adjunctive treatment in ocular inflammation or trauma. / Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

The objective of the proposed research is to develop structural changes to the design and application of electromagnetic (EM) sensing models to more efficiently and accurately invert EM measurements to extract parameters for applications such as landmine detection. Two different acquisition modalities are addressed in this research: ground-penetrating radar (GPR) and electromagnetic induction (EMI) sensors. The models needed for practical three-dimensional (3D) spatial imaging typically become impractically large, with up to seven dimensions of parameters that need to be extracted. These parameters include, but are not limited to target type, 3D location, and 3D orientation. The new special structures for these models exploit properties such as shift invariance and tensor representation, which can be combined with strategic inversion techniques, including the Fast Fourier Transform and semidefinite programming. The structures dramatically reduce the amount of computation and can eliminate the need to store up to five dimensions of parameters while still accurately estimating them.

Exact analytical solutions for the quasistationary electromagnetic fields in the presence of conducting objects require the field solutions both internal and external to the conductors. Such solutions are limited for certain canonically shaped objects but are useful in testing the accuracy of various approximate models and numerical methods developed to solve complex problems related to real world conducting objects and in calibrating instruments designed to measure various field quantities. Theoretical investigations of quasistationary electromagnetic fields also aid in improving the understanding of the physical phenomena of electromagnetic induction. This thesis presents rigorous analytical expressions derived as benchmark solutions for the quasistationary field quantities both inside and outside, Joule losses and the electromagnetic forces acting upon a conducting spheroid placed in the proximity of a non-uniform field produced by current-carrying turns. These expressions are used to generate numerous numerical results of specified accuracy and selected results are presented in a normalized form for extended ranges of the spheroid axial ratio, the ratio of the depth of penetration to the semi-minor axis and the position of the inducing turns relative to the spheroids. They are intended to constitute reference data to be employed for comprehensive comparisons of results from approximate numerical methods or from boundary impedance models used for real world conductors. Approximate boundary conditions such as the simpler perfect electric conductor model or the Leontovich surface impedance boundary condition model can be used to obtain approximate solutions by only analyzing the field external to the conducting object. The range of validity of these impedance boundary condition models for the analysis of axisymmetric eddy-current problems is thoroughly investigated. While the simpler PEC model can be employed only when the electromagnetic depth of penetration is much smaller than the smallest local radius of curvature, the results obtained using the surface impedance boundary condition model for conducting prolate and oblate spheroids of various axial ratios are in good agreement with the exact results for skin depths of about 1/5 of the semi-minor axis when calculating electromagnetic forces and for skin depths less than 1/20 of the semi-minor axis when calculating Joule losses.

There is evidence that athermal radiofrequency radiation can alter Heat Shock Protein (HSP) expression or protein phosphorylation, or alter MAP kinase signalling. Effects of long-term exposure in brain tissue due to repeated HSP perturbation (eg an inhibition of apoptosis) have been hypothesised (French et al, 2001). This study aimed to investigate the RNA expression profile (12,000 genes) and HSP family protein expression levels after either acute 1-hour or chronic 4-day intermittent exposures to simulated GSM radiation in a human primary fibroblast model. The results found minimal or no effects of GSM. Flasks were exposed to 900 MHz (217 Hz modulation) at 0.18 W/kg SAR within a Transverse Electromagnetic Mode chamber (TEM cell). Cultures rested for 2 hours before exposures. Affymetrix U95A microarray analysis of a single pilot set of experiments showed that about 40 genes were reported as upregulated &gt=2.5 fold in each condition. There was no evidence of altered expression of any MAPK-associated genes. Target genes reported in both conditions (CBFA2T1, ZNF148, ITGA1), and genes altered in one condition (CCS, PLEC1, BIRC5), and marginally altered HSP72 were selected for PCR analysis. No other members of the HSP family were altered. In three replicate experiments assayed by real-time PCR, six genes were either unchanged or showed randomly variable expression. However HSP72 RNA showed possible consistent slight upregulation of 1.37 +/- 0.21 in the chronic condition. Western immunoblots of HSP-60, -70, -72 and -V90 proteins showed no significant changes 5 hours after exposure. In preliminary studies using a serum starvation protocol, ERK-1 phosphorylation was unaltered after 5 or 30 minutes GSM (single experiments). When flasks were transiently cooled, ERK-1 phosphorylation was increased 20 minutes later, indicating a source of artefact in some protocols. An inflammatory challenge experiment with a low-dose of the cytokine IL-1???? found that acute GSM exposure post-challenge inhibited NF????B-mediated GRO???? induction by 1.5 fold (2 experiments). Preconditioning with mild heat induces transient inhibition of both NF????B signalling and apoptosis. Other studies indicate that EMF exposures similarly evoke cytoprotection. It is suggested that GSM evoked cytoprotective signalling in this inflammatory model.

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.

This thesis aims to develop a calculation method to determine themagnetic field magnitudes in the vicinity of power lines, i.e. bothburied cables and overhead lines. This is done through the numericaluse of Biot Savart's law where the conductors are approximated by aseries of straight segment elements that each contribute to the overallfield strength at the field point. The method is compared to two realcases and to the exact integral solution. Also, a review of some of theresearch material regarding electromagnetic fields from power lines andclaims of adverse health effects due to these fields is conducted.Results show that the numerical error is dependent on the segmentationdegree of the conductors and the mathematical model is inaccurate closeto the conductor. The calculations show slightly higher fieldmagnitudes than the previous survey done by WSP (Williams SalePartnership) far away from the source and slightly lower at the centerconductor. This may be due to the excluded induction in the shieldwires and differences in actual conductor coordinates.

In 1865 Maxwell outlined the theoretical framework for electromagnetic field propagation. Since then many important developments have been made in the field, with an emphasis on systems using high frequencies for long-range interactions. It was not until recent years that applications based on short-range inductive coupling demonstrated the advantages of using low frequency transmissions with magnetic fields to transfer power and information. This thesis investigates magnetic transmissions in the near-field and the possibility of producing induced voltages in printed circuit boards. A near-field magnetic induction system is designed to generate a magnetic flux in the very low frequency region, and used experimentally to evaluate circuit board induction in several interesting environments. The resulting voltages are measured with digital signal processing techniques, using Welch’s method to estimate the spectrum of the received voltage signal. The results show that the amount of induced voltage is proportional to the inverse cube of the transmission distance, and that the system is able to achieve a maximum induced voltage of 65 \micro V at a distance of 2.5 m and under line-of-sight conditions. It is also concluded that conductive obstructions, electromagnetic shielding and background noise all have a large impact on the obtained voltage, either cancelling the signal or causing it to fluctuate.

The resolution of optical instruments is normally limited by the wave nature of light. Circumventing this limit, known as the diffraction limit of imaging, is of tremendous practical importance for modern science and technology. One method, super-resolved fluorescence microscopy was distinguished with the Nobel Prize in Chemistry in 2014, but there is plenty of room for alternatives and complementary methods such as the pioneering work of Prof. J. Pendry on the perfect lens based on negative refraction that started the entire research area of metamaterials. In this thesis, we have used analytical techniques to solve several important challenges that have risen in the discussion of the microwave experimental demonstration of absolute optical instruments and the controversy surrounding perfect imaging. Attempts to overcome or circumvent Abbe's diffraction limit of optical imaging, have traditionally been greeted with controversy. In this thesis, we have investigated the role of interacting sources and detectors in perfect imaging. We have established limitations and prospects that arise from interactions and resonances inside the lens. The crucial role of detection becomes clear in Feynman's argument against the diffraction limit: “as Maxwell's electromagnetism is invariant upon time reversal, the electromagnetic wave emitted from a point source may be reversed and focused into a point with point-like precision, not limited by diffraction.” However, for this, the entire emission process must be reversed, including the source: A point drain must sit at the focal position, in place of the point source, otherwise, without getting absorbed at the detector, the focused wave will rebound and the superposition of the focusing and the rebounding wave will produce a diffraction-limited spot. The time-reversed source, the drain, is the detector which taking the image of the source. In 2011-2012, experiments with microwaves have confirmed the role of detection in perfect focusing. The emitted radiation was actively time-reversed and focused back at the point of emission, where, the time-reversed of the source sits. Absorption in the drain localizes the radiation with a precision much better than the diffraction limit. Absolute optical instruments may perform the time reversal of the field with perfectly passive materials and send the reversed wave to a different spatial position than the source. Perfect imaging with absolute optical instruments is defected by a restriction: so far it has only worked for a single–source single–drain configuration and near the resonance frequencies of the device. In chapters 6 and 7 of the thesis, we have investigated the imaging properties of mutually interacting detectors. We found that an array of detectors can image a point source with arbitrary precision. However, for this, the radiation has to be at resonance. Our analysis has become possible thanks to a theoretical model for mutually interacting sources and drains we developed after considerable work and several failed attempts. Modelling such sources and drains analytically had been a major unsolved problem, full numerical simulations have been difficult due to the large difference in the scales involved (the field localization near the sources and drains versus the wave propagation in the device). In our opinion, nobody was able to reproduce reliably the experiments, because of the numerical complexity involved. Our analytic theory draws from a simple, 1–dimensional model we developed in collaboration with Tomas Tyc (Masaryk University) and Alex Kogan (Weizmann Institute). This model was the first to explain the data of experiment, characteristic dips of the transmission of displaced drains, which establishes the grounds for the realistic super-resolution of absolute optical instruments. As the next step in Chapter 7 we developed a Lagrangian theory that agrees with the simple and successful model in 1–dimension. Inspired by the Lagrangian of the electromagnetic field interacting with a current, we have constructed a Lagrangian that has the advantage of being extendable to higher dimensions in our case two where imaging takes place. Our Lagrangian theory represents a device-independent, idealized model independent of numerical simulations. To conclude, Feynman objected to Abbe's diffraction limit, arguing that as Maxwell's electromagnetism is time-reversal invariant, the radiation from a point source may very well become focused in a point drain. Absolute optical instruments such as the Maxwell Fisheye can perform the time reversal and may image with a perfect resolution. However, the sources and drains in previous experiments were interacting with each other as if Feynman's drain would act back to the source in the past. Different ways of detection might circumvent this feature. The mutual interaction of sources and drains does ruin some of the promising features of perfect imaging. Arrays of sources are not necessarily resolved with arrays of detectors, but it also opens interesting new prospects in scanning near-fields from far–field distances. To summarise the novel idea of the thesis: • We have discovered and understood the problems with the initial experimental demonstration of the Maxwell Fisheye. • We have solved a long-standing challenge of modelling the theory for mutually interacting sources and drains. • We understand the imaging properties of the Maxwell Fisheye in the wave regime. Let us add one final thought. It has taken the scientific community a long time of investigation and discussion to understand the different ingredients of the diffraction limit. Abbe's limit was initially attributed to the optical device only. But, rather all three processes of imaging, namely illumination, transfer and detection, make an equal contribution to the total diffraction limit. Therefore, we think that for violating the diffraction limit one needs to consider all three factors together. Of course, one might circumvent the limit and achieve a better resolution by focusing on one factor, but that does not necessary imply the violation of a fundamental limit. One example is STED microscopy that focuses on the illumination, another near–field scanning microscopy that circumvents the diffraction limit by focusing on detection. Other methods and strategies in sub-wavelength imaging –negative refraction, time reversal imaging and on the case and absolute optical instruments –are concentrating on the faithful transfer of the optical information. In our opinion, the most significant, and naturally the most controversial, part of our findings in the course of this study was elucidating the role of detection. Maxwell's Fisheye transmits the optical information faithfully, but this is not enough. To have a faithful image, it is also necessary to extract the information at the destination. In our last two papers, we report our new findings of the contribution of detection. We find out in the absolute optical instruments, such as the Maxwell Fisheye, embedded sources and detectors are not independent. They are mutually interacting, and this interaction influences the imaging property of the system.

Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-02-03T11:57:50Z No. of bitstreams: 0 / Made available in DSpace on 2016-02-03T11:57:50Z (GMT). No. of bitstreams: 0 / Tese (Doutorado em Tecnologia Nuclear) / IPEN/T / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP