Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-03-02T23:14:27Z No. of bitstreams: 1 AldilaneGoncalvesDaFonseca_DISSERT.pdf: 2225811 bytes, checksum: 5e7b981fdc77d287792a011dffc52374 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-03-04T23:20:31Z (GMT) No. of bitstreams: 1 AldilaneGoncalvesDaFonseca_DISSERT.pdf: 2225811 bytes, checksum: 5e7b981fdc77d287792a011dffc52374 (MD5) / Made available in DSpace on 2016-03-04T23:20:31Z (GMT). No. of bitstreams: 1 AldilaneGoncalvesDaFonseca_DISSERT.pdf: 2225811 bytes, checksum: 5e7b981fdc77d287792a011dffc52374 (MD5) Previous issue date: 2014-09-25 / As esp?cies do g?nero Kalanchoe (Crassulaceae) s?o bastante utitlizadas em todo o Brasil, como medicamento para tratar tosse, fur?nculos, gastrite e outras enfermidades. Nesse cen?rio destaca-se K. brasiliensis, conhecida popularmente como coirama ou sai?o. Este trabalho tem como proposta a exposi??o por via oral de camundongos a um extrato hidroalco?lico de folhas de Kalanchoe brasiliensis. Os animais (total de 100) foram divididos em grupos de 12 (6 machos e 6 f?meas) para avalia??o aguda; e grupos de 10 para avalia??o subcr?nica.Os grupos teste foram tratados com doses de 250 mg/Kg, 500 mg/Kg, 1000 mg/Kg e 2000 mg/Kg, e o grupo controle recebeu solu??o salina 0,9 %. Os animais foram observados por 14 dias para avalia??o aguda e 30 dias para avalia??o subcr?nica, e nesse per?odo analisou-se o aparecimento de sinais cl?nicos, altera??es no peso e no consumo de ?gua e ra??o. Ap?s o per?odo de observa??o, foram realizadas a an?lise histopatol?gica dos ?rg?os, as concentra??es s?ricas bioqu?micas e par?metros hematol?gicos para os grupos da avalia??o subcr?nica. N?o foram observadas diferen?as e altera??o do peso corp?reo entre os grupos, nem de consumo de ?gua e ra??o, tamb?m n?o houve mortes entre os grupos, nos dois tipos de ensaios. As an?lises histopatol?gicas demonstraram algumas altera??es compat?veis com baixa toxicidade aguda hep?tica. Os resultados de glicemia, triglicer?deos, ALT, ureia e creatinina mostraram diferen?as entre o grupo controle e os testes nas concentra??es estudadas (p<0,05), por?m estas diferen?as n?o demonstram mudan?a relevante no quadro cl?nico dos animais. Os resultados mostraram que o extrato de K. brasiliensis apresenta baixa toxicidade aguda nas doses utilizadas e n?o apresenta toxicidade quando administrado durante 30 dias. Isto destaca a import?ncia desta esp?cie como futuro e promissor candidato a fitoter?pico, assim que tenha seus ensaios farmacol?gicos conclu?dos. / The species of the genus Kalanchoe (Crassulaceae) are widely used in Brazil as a medicinal product to treat cough, boils, gastritis and other diseases. In this scenario stands out K. brasiliensis, popularly known as coirama or sai?o. This paper aims at the oral exposure of mice to a hydroalcoholic extract of leaves of Kalanchoe brasiliensis. The animals (total of 100) were divided into 12 groups (6 males and 6 females) for the acute assessment; and groups of 10 for subchronic evaluation. Test groups were treated with doses of 250 mg / kg, 500 mg / kg, 1000 mg / kg and 2000 mg / kg and the control group received 0.9% saline. The animals were observed for 14 days for acute evaluation and 30 days for subchronic evaluation, and in that period analyzed the appearance of clinical signs, changes in weight and consumption of water and food. After the observation period, histopathological analysis of the organs, biochemical serum and haematological parameters for the assessment of the subchronic groups were processed. Differences and changes in body weight were not observed among the groups, nor consumption of water and food, there were no deaths among the groups in the two types of assays. Histopathological analysis showed some alterations compatible with low acute hepatic toxicity. The results of blood glucose, triglycerides, ALT, urea and creatinine showed differences between the control group and the test concentrations studied (p <0.05), but these differences do not show relevant change in the clinical picture of animals. The results showed that the extract K. brasiliensis has low acute toxicity at the doses used and no toxicity when administered for 30 days. This highlights the importance of this species as future and promising candidate for phytotherapics, so has its pharmacological trials completed.