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91	Comparing the performance of a targeted pull-down assay to shotgun sequencing for improving respiratory infectious disease surveillance Christian, Monica R. 07 June 2023 (has links) No description available. Public Health Molecular Biology Biology infectious disease sequencing hybrid capture respiratory virus Influenza A Influenza B Coronavirus Adenovirus 7 Adenovirus Enterovirus D68 respiratory disease surveillance whole transcriptome Illumina MiSeq Pull-down respiratory disease pandemic
92	CLINICAL SEVERITY OF RHINOVIRUS/ENTEROVIRUS COMPARED TO OTHER RESPIRATORY VIRUSES IN CHILDREN Asner, Andrea Sandra 10 1900 (has links) <p><strong>Background</strong>: Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remains limited. We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU) and other common respiratory virus in children.</p> <p><strong>Methods</strong>: Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite end-point consisting of intensive care admission, hospitalization greater than 5 days, oxygen requirements or death.</p> <p><strong>Results</strong>: A total of 116 HRV/ENT, 102 RSV, 99 FLU and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37.9% vs 13.6%; p</p> <p><strong>Conclusions</strong>: Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections.</p> / Master of Science (MSc) Human rhinovirus/enterovirus (HRV/ENT) respiratory syncytial virus (RSV) influenza (FLU) single viral infections clinical disease severity acute respiratory infections upper respiratory tract infections lower respiratory tract infections community-acquired pneumonia molecular assays Infectious Disease Medicine and Health Sciences Pediatrics Infectious Disease

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Comparing the performance of a targeted pull-down assay to shotgun sequencing for improving respiratory infectious disease surveillance

CLINICAL SEVERITY OF RHINOVIRUS/ENTEROVIRUS COMPARED TO OTHER RESPIRATORY VIRUSES IN CHILDREN