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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.013 seconds)Spelling suggestions: "subject:"epaxial"" "subject:"paxial""
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A Novel Role for Lunatic Fringe in the Development of Epaxial MusculatureJanuary 2012 (has links)
abstract: Skeletal muscles arise from the myotome compartment of the somites that form during vertebrate embryonic development. Somites are transient structures serve as the anlagen for the axial skeleton, skeletal muscle, tendons, and dermis, as well as imposing the metameric patterning of the axial musculoskeletal system, peripheral nerves, and vasculature. Classic studies have described the role of Notch, Wnt, and FGF signaling pathways in controlling somite formation and muscle formation. However, little is known about the transformation of myotome compartments into identifiable post-natal muscle groups. Using a mouse model, I have undertaken an evaluation of morphological events, including hypertrophy and hyperplasia, related to the formation of several muscles positioned along the dorsal surface of the vertebrae and ribs. Lunatic fringe (Lfng) deficient embryos and neonates were also examined to further understand the role of the Notch pathway in these processes as it is a modulator of the Notch receptor and plays an important role in defining somite borders and anterior-posterior patterning in many vertebrates. Lunatic fringe deficient embryos showed defects in muscle fiber hyperplasia and hypertrophy in the iliocostalis and longissimus muscles of the erector spinae group. This novel data suggests an additional role for Lfng and the Notch signaling pathway in embryonic and fetal muscle development. / Dissertation/Thesis / M.S. Biology 2012
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Muster und Funktionen von Apoptose und Proliferation während der Morphogenese der Somiten von <i>Tupaia belangeri</i> (Tupaiidae, Scandentia, Mammalia) / Patterns and functions of apoptosis and proliferation during the morphogenesis of somites in <i>Tupaia belangeri</i> (Tupaiidae, Scandentia, Mammalia)Büttner, Benedikt 30 January 2012 (has links)
No description available.
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