Equivalent Lateral Force Method (ELF) and Response Spectrum Analysis (RSA) are the two most popular methods of seismic design of structures. This study aims to present a comparative study of the two methods using hand-calculated approach as well as computer analysis according to ASCE 7-10 Standards. The two methods have been compared in terms of base shear and story forces by analyzing various models for different number of stories and different support conditions. It was found that ELF gives conservative results in comparison to RSA. This result was more obvious in case of four-story frames. Hence, for structures of increased elevation, the analysis from ELF may not be sufficient.