Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-08-27T00:05:27Z No. of bitstreams: 1 JulianaCavalcanteDeMoura_DISSERT.pdf: 760946 bytes, checksum: 79fcb1d384593cd9eac3c22ff91eda87 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-08-31T23:24:44Z (GMT) No. of bitstreams: 1 JulianaCavalcanteDeMoura_DISSERT.pdf: 760946 bytes, checksum: 79fcb1d384593cd9eac3c22ff91eda87 (MD5) / Made available in DSpace on 2016-08-31T23:24:44Z (GMT). No. of bitstreams: 1 JulianaCavalcanteDeMoura_DISSERT.pdf: 760946 bytes, checksum: 79fcb1d384593cd9eac3c22ff91eda87 (MD5) Previous issue date: 2016-03-22 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / A reativa??o pode levar as mem?rias consolidadas a um novo estado de labilidade, tornando-as suscet?veis ? incorpora??o de nova informa??o atrav?s de um processo de reestabiliza??o dependente da express?o g?nica e da s?ntese de novas prote?nas conhecido como reconsolida??o. A interrup??o da reconsolida??o usualmente produz amn?sia. Contudo, algumas mem?rias s?o particularmente resistentes a agentes bloqueadores da reconsolida??o, indicando que este processo ocorre somente quando ? dada uma s?rie espec?fica de condi??es. Utilizando ferramentas farmacol?gicas e comportamentais, neste trabalho demonstramos que a consolida??o pr?via de informa??o n?o aversiva ? essencial para a reconsolida??o da mem?ria de esquiva inibit?ria em ratos. / Reactivation can render consolidated memories labile again, making them prone to incorporate new information through a gene-expression and protein synthesis dependent restabilization process referred to as reconsolidation. Disruption of reconsolidation usually produces amnesia. However, some memories are particularly resilient to reconsolidation blockers, indicating that this process is not a pervasive quality of memory but happens only when a precise set of conditions occurs. Using pharmacological and behavioral tools we demonstrated that previous consolidation of non-aversive information is essential for aversive memory reconsolidation.