?rea de concentra??o: Cl?nica Odontol?gica. / Linha de pesquisa: Les?es inflamat?rias, c?sticas e neopl?sicas da cavidade bucal. / Na Folha de Rosto e Ficha Catalogr?fica da obra consta o t?tulo: "Avalia??o dos efeitos anti-inflamat?rio e antiedematog?nico do gel Oxyflower? em modelo de edema de pata induzido por adjuvante completo de Freund em ratos". / Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-05-22T17:57:16Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) timilliy_mayra_martins_cruz.pdf: 1084452 bytes, checksum: e81ee908ce5c1b999b746646f5a03878 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2018-06-05T14:41:12Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) timilliy_mayra_martins_cruz.pdf: 1084452 bytes, checksum: e81ee908ce5c1b999b746646f5a03878 (MD5) / Made available in DSpace on 2018-06-05T14:41:12Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) timilliy_mayra_martins_cruz.pdf: 1084452 bytes, checksum: e81ee908ce5c1b999b746646f5a03878 (MD5) Previous issue date: 2017 / Introdu??o: A inflama??o ? um mecanismo de defesa prim?ria que protege o organismo de est?mulos nocivos ou prejudiciais. Os medicamentos anti-inflamat?rios tais como os Anti-Inflamat?rios N?o Esteroidais (AINEs) e os corticoster?ides s?o utilizados para tratar os dist?rbios inflamat?rios, por?m, diversos efeitos colaterais t?m sido relatados. Neste contexto, produtos naturais t?m contribu?do bastante para o desenvolvimento de terapias farmacol?gicas modernas e eficazes. Alguns medicamentos naturais apresentam grande potencial terap?utico, como por exemplo, o Oxyflower?. Este rem?dio baseia-se na a??o de ess?ncias florais, por?m seus efeitos biol?gicos ainda n?o foram devidamente investigados. Objetivos: Investigar os poss?veis efeitos anti-inflamat?rio e antiedematog?nico do gel Oxyflower? em modelo animal de inflama??o cr?nica. Metodologia: 25 ratos machos da linhagem Holtzman foram aleatoriamente divididos em 5 grupos experimentais (controle, ve?culo do Oxyflower?, Oxyflower?, triancinolona acetonida e diclofenaco dietilam?nio). A inflama??o foi quimicamente induzida por meio da inje??o de 200 ?L de Adjuvante Completo de Freund (ACF) na pata traseira direita dos ratos. O volume e espessura das patas dos ratos foram mensurados com pletism?metro de pata e paqu?metro digital, respectivamente. Durante 14 dias, os animais foram tratados com os f?rmacos e tiveram acompanhamento de sua massa corporal. Neste per?odo a temperatura das patas traseiras foram avaliadas com um term?grafo digital. Foram realizadas an?lises histol?gicas e leucometria. Os dados foram analisados como m?dia ? erro padr?o ou desvio padr?o da m?dia e apresentados como a varia??o (delta) do volume, espessura e temperatura das patas traseiras. As diferen?as entre os grupos foram analisadas pelos testes de vari?ncia ANOVA (two e one-way), seguidos do post hoc de Tukey e teste Qui-Quadrado. Valores de p< 0,05 foram considerados significativos. Resultados: O gel Oxyflower? promoveu redu??es no volume, espessura e temperatura das patas dos ratos, injetados com ACF, quando comparados aos animais do grupo controle. N?o houve diferen?a em rela??o ao ganho de massa corporal nos diferentes grupos experimentais. Os resultados para leucometria e histologia n?o apresentaram diferen?as significativas entre os grupos. Conclus?o: O gel Oxyflower? apresentou atividade antiedematog?nica semelhante ? Triancinolona e ao Diclofenaco. A termografia infravermelha ? um m?todo aplic?vel na avalia??o da temperatura tecidual associada ao edema, neste modelo experimental. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017. / Introduction: Inflammation is a primary defense mechanism that protects the body from harmful or harmful stimuli. Anti-inflammatory drugs such as non-steroidal antiinflammatory drugs (NSAIDs) and corticosteroids are used to treat inflammatory disorders, but several side effects have been reported. Thus, natural products have contributed greatly to the development of modern and effective pharmacological therapies. Some natural medicines have great therapeutic potential, such as Oxyflower?. This drug is based on the action of flower essences, but its biological effects have not yet been properly investigated. Objectives: To investigate the possible anti-inflammatory and anti-infective effects of Oxyflower? gel in an animal model of chronic inflammation. Methods: 25 male rats of the Holtzman strain were randomly divided into 5 experimental groups (control, Oxyflower? vehicle, Oxyflower?, triamcinolone acetonide and diclofenac diethylammonium). Inflammation was chemically induced by injecting 200 ?L of Complete Freund's Adjuvant (CFA) into the right hind paw of rats. The volume and thickness of the paws of the rats were measured with a paw plethysmometer and digital caliper, respectively. During 14 days, the animals were treated with the drugs and had monitoring of their body mass. In this period the temperature of the hind legs were evaluated with a digital thermograph. Histological analysis and leukometry were performed. Data were analyzed as mean ? standard error or standard deviation of the mean and presented as the variation (delta) of the volume, thickness and temperature. The differences between the groups were analyzed by ANOVA (two and one-way) variance tests, followed by Tukey post hoc and Chi-Square test. Values of p <0.05 were considered significant. Results: The Oxyflower? gel promoted reductions in the volume, thickness and temperature of the legs of the rats injected with ACF when compared to the animals of the control group. There was no difference in relation to body mass gain in the different experimental groups. The results for leucometry and histology did not show significant differences between the groups. Conclusion: Oxyflower? gel presented antiedematogenic activity similar to Triamcinolone and Diclofenac. Infrared thermography is an applicable method for evaluation of tissue temperature associated with edema, in this experimental model. Infrared thermography is an applicable method for assessing tissue temperature associated with edema in this experimental model. The antiinflammatory effect of Oxyflower? gel could not be confirmed. However, biomolecular, immunological and immunohistochemical analyzes may help confirm the possible antiinflammatory effect of Oxyflower? gel.