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Synthesis of Sugar-Derived Esters and Carbamate CompoundsTatebe, Caleb J. 04 September 2014 (has links)
No description available.
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Applications of sugar-based microemulsion glassesShoop, Brian H. January 2009 (has links)
No description available.
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Identification of Proteins from Lanthionine Ketimine Ethyl Ester (LKE)- treated and untreated Rat Glioma 2 (RG2) Cells using Proteomic ApproachesShirsat, Siddhita Abhijeet, Shirsat January 2016 (has links)
No description available.
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Corrosion Behavior of Epoxy Ester Urea Hybrid Nanocomposites Containing Clay and Organo Silanes Prepared by In Situ ProcessingZhang, Yujie 21 October 2016 (has links)
No description available.
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compoundsThorpe, Steven Brandon 03 May 2012 (has links)
The first successful synthesis and isolation of a boronic acid was reported in 1860 by Frankland in the pursuit of novel organometallic compounds. For more than a century, further studies of boronic acids were sparsely published. Suzuki and Miyaura jumpstarted the field in 1979 with an innovative carbon-carbon bond forming reaction employing an organoboronic acid and a carbon halide under palladium catalysis. Indeed, the Nobel Prize in Chemistry was awarded to Professor Akira Suzuki, along with Professors Richard Heck and Ei-ichi Negishi, in 2010 for their important contributions in palladium-catalyzed cross-coupling chemistry. Over the last 30 years, reports on organoboron compounds have increased exponentially. This dissertation describes the author's contributions to the development of preparative methods for organoboronic acid derivatives using transition metal-catalyzed reactions of diboron reagents.
A unique "mixed" diboron reagent was developed (PDIPA diboron) that contains sp2- and sp3-hybridized boron atoms, unambiguously confirmed by X-ray crystallography. PDIPA diboron is sufficiently activated internally through a dative-bonding amine to selectively transfer the sp2-hybridized boron regioselectively, in the presence of copper, to electron deficient alkenes including α,β-unsaturated ketones, esters, amides, aldehydes, and nitriles to provide the corresponding boratohomoenolates. A unique β,β-diboration of an α,β-acetylenic ketone was also discovered.
The scope of PDIPA diboron reactions was then expanded to a set of substrates with a more complex structural backbone. Allenoates are α,β,γ-unsaturated esters with orthogonal pi systems, which pose several possible difficulties with the regioselectivity of addition, not to mention known isomerizations catalyzed by copper. However, we successfully installed the boron moiety regioselectively on the β-carbon of a variety of allenoates, providing a vinyl boronic ester, and also observed exclusive formation of the (Z)-isomer from racemic starting materials. The resulting vinyl boronic ester was then shown to be an excellent Suzuki-Miyaura cross-coupling partner, affording a diastereopure, trisubstituted alkene in quantitative yield.
Commercially available bis(pinacolato)diboron has shown remarkable stability towards hydrolysis and autoxidation. Using this reagent, we developed a copper- and amine-catalyzed boration protocol performed entirely in water and open to air. Using only 1 mol% copper, extraordinary activity was observed. UV-Vis, 11B NMR, and solvent kinetic isotope experiments were employed to gain insight into the mechanism, which showed the possibility of autocatalysis. Attempts to control stereoselectivity were not successful, although these results were rationalized by a dynamic catalyst structure. / Ph. D.
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Regioselective chlorination of cellulose estersGao, Chengzhe 31 July 2018 (has links)
Chemical modification of cellulose has been of growing interest, owing to the abundance and processing challenges of natural cellulose. To date, etherification and esterification are the most effective strategies to modify physicochemical properties of cellulose and append new functionalities. However, they typically require relatively harsh conditions, thus limiting introduction of new functional groups. An alternative strategy to synthesize novel cellulose derivatives is to append a good leaving group to cellulose backbone, followed by nucleophilic substitution reaction. Though tosylation and bromination of cellulose are frequently used, they have drawbacks such as chemo- and regioselectivity issues, high cost, and difficulty in purification. We have successfully developed a method to chemo- and regioselectively chlorinate cellulose esters using MsCl. Compared to bromination of cellulose typically used, this chlorination method has many advantages, including low cost of reagents and ease of separation. The chlorinated cellulose esters are useful intermediates for appending new functionalities by displacement reactions. We have synthesized a library of cellulose ester derivatives by this chlorination/nucleophilic substitution strategy, including cationic and anionic cellulose ester derivatives. These cellulose ester derivatives possess great potentialiii for various applications, including amorphous solid dispersion, tight junction opening, anionic drug delivery, and gas separation membranes. / MS
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Tracing the architecture of caffeic acid phenethyl ester cocrystals: studies on crystal structure, solubility, and bioavailability implicationsKetkar, S.S., Pagire, Sudhir K., Goud, N.R., Mahadik, K.R., Nangia, A., Paradkar, Anant R 2016 August 1919 (has links)
Yes / Caffeic acid phenethyl ester (CAPE) is a polyphenolic active compound present in popular apiproduct, ‘propolis’ obtained from beehives. Though it has broad therapeutic capability, the bioavailability of CAPE is limited due to poor solubility. In this study, we report novel cocrystals of CAPE engineered using coformers such as caffeine (CAF), isonicotinamide (INIC), nicotinamide (NIC) with enhanced solubility and bioavailability of CAPE. The cocrystals were prepared by microwave-assisted cocrystallization and characterized using PXRD, DSC and Raman spectroscopy. PXRD and DSC confirm the successful formation and phase purity of CAPE-CAF, CAPE-INIC and CAPE-NIC cocrystals. Raman spectra of CAPE cocrystals complement these results in confirming the formation of novel crystalline phases. CAPE-NIC cocrystal was further subjected to X-ray crystallography to understand its molecular arrangement and hydrogen bonding in the crystal structure. The CAPE-NIC cocrystal structure is found to be stabilized by a rare 1,2-benzenediol-amide heterosynthon. Cocrystallization of CAPE with NIC improved its aqueous solubility and pharmacokinetic profile thereby demonstrating 2.76 folds escalation in bioavailability. / We thank UKIERI: UK-India Education and Research Initiative (TPR26) and EPSRC (EP/J003360/1, EP/L027011/1) for providing financial support during this study.
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Mise en œuvre des lipases végétales issues des graines dans la catalyse enzymatique d’esters éthyliques d’huiles végétales pour la production de biodiesel / Use of plant lipases from seeds for enzymatic catalysis of ethyl esters of vegetable oils for the production of biodieselKouteu Nanssou, Paul 31 May 2017 (has links)
Les lipases présentent un grand intérêt pour la synthèse du Biodiesel, carburant alternatif au gasoil, généralement obtenu d’une transestérification des triacylglycérols avec un alcool, la plupart du temps le méthanol. Pour avoir un ester issu totalement de la biomasse végétale, l’éthanol peut être utilisé comme accepteur d’acyle. L’objectif de cette étude est de développer des procédés enzymatiques de synthèses d’esters éthyliques catalysés par les lipases végétales sous leur forme brute avec des intrants (huile et alcool) d’origine végétale. D’abord, elle a consisté à la mise en évidence d’une activité lipasique pour des réactions d’éthanolyse et d’hydrolyse par les graines d’A. suarezensis, d’A. grandidieri, de J. curcas, de J. mahafalensis, de M. oleifera et de M. drouhardii. Ensuite, les influences de certains facteurs sur la capacité des extraits le(s) plus actif(s) à réaliser des réactions d’éthanolyse en milieux non aqueux, aqueux et en utilisant comme substrat leurs lipides natifs ont été étudiées. Enfin, des essais de combustion ont été menés sur un moteur monocylindre à injection directe pour l’étude des performances, des émissions et de la combustion du biodiesel produit et de ses mélanges avec le gasoil. Toutes les graines germées sont dotées d’une activité en hydrolyse et éthanolyse. La poudre d’A. grandidieri est la plus active en éthanolyse. Avec cette dernière, deux procédés ont pu être développés : un en milieu non aqueux et un en milieu aqueux (respectivement un rendement de 96,2 % et 96,3 %). Elle est aussi capable de transformer ses lipides natifs sans extraction au préalable en esters éthyliques (rendement de 91,6%). Les performances et la combustion du biodiesel et de ses mélanges sont similaires à celle du gasoil. Une réduction significative des émissions de CO, NOX, CO2 et SO2 au cours de la combustion du biodiesel et de ses mélanges est observée. Ces résultats montrent que les lipases végétales exploitées sous leurs formes brutes peuvent être une alternative aux lipases microbiennes et aux catalyseurs chimiques. / There is a great interest in the use of lipase in the production of Biodiesel, alternative diesel fuel, usually obtained from a transesterification of triacylglycerol with an alcohol which is mostly methanol. To have a biodiesel derived totally from vegetable biomass, ethanol must be explored as acyl acceptor. The objective of this work is to develop enzymatic processes for the synthesis of ethyl esters catalyzed by plant lipases in their crude form with all inputs (oil and alcohol) of origin plant. Firstly, the hydrolysis and ethanolysis activities of A. suarezensis, A. grandidieri, J. curcas, J. mahafalensis, M. oleifera and M. drouhardii seeds were assessed. Subsequently, the most active(s) plant lipase(s) was selected to study the effects of some factors on their ability to carry out ethanolysis reactions in nonaqueous, aqueous media and using as substrate their lipids. Finally, combustion tests were carried out on a single cylinder direct injection engine to study the performance, emissions and combustion of biodiesel and its mixture with diesel. All germinated seeds have hydrolysis and ethanolysis activity. The most active in ethanolysis is the powder from A. grandidieri seed. With this powder, two processes were developed: one in nonaquous medium and the other in aqueous medium (yield of 96.2 % and 96.3 %, respectively). Lipase from A. grandidieri seed is able to transesterify its oils without an extraction thereof into ethyl ester. Performance and combustion characteristics of biodiesel and its mixtures are similar to that of diesel fuel. A significant reduction in CO, NOX, CO2 and SO2 emissions during the combustion of biodiesel and its mixtures is observed. These results show that plant lipases exploited in their crude form can be an alternative to microbial lipases and chemical catalysts.
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Estudo químico e biológico de espécies do gênero Erythroxylum P. Browne coletadas no Sul do BrasilHofmann Junior, Arno Ernesto January 2018 (has links)
O gênero Erythroxylum P. Browne pertence a família Erythroxylaceae Kunth e é principalmente conhecido devido as espécies E. coca e E. novogranatense, as “plantas da coca”. O gênero é a única fonte natural da cocaína e de outros alcaloides com núcleo ecgonina, principais responsáveis pelos efeitos tóxicos e biológicos originados pelo consumo de suas espécies. A presença da cocaína é amplamente aceita para as plantas de coca, porém a sua biossíntese por outras espécies apresenta divergência, o que pode estar relacionada ao período de coleta. Além destas particularidades fitoquímicas, as espécies do gênero também apresentam importantes atividades como antioxidante e antimicrobiana, além de toxicidade a humanos e a ovinos. O Brasil é o centro da diversidade e do endemismo do gênero e no sul do país, nos estados do Rio Grande do Sul e de Santa Catarina, as carcaterísticas fitoquímicas e potencialidades tóxicas e farmacológicas das espécies apresentam um campo aberto para estudos. Desta forma, foram avaliadas características fitoquímicas e potencialidades tóxicas e farmacológicas de espécies nativas dos estados do Rio Grande do Sul e de Santa Catarina, coletadas em dois períodos climáticos distintos, verão e inverno, além de revisão bibliográfica sobre as espécies produtoras de cocaína e as implicações segundo a legislação brasileira vigente. Foram utilizadas metodologia de planária, disco-difusão em ágar, microdiluição em caldo, medida da extinção da absorção do cátion 2,2-difenil-1-picrilhidrazil e procedimentos preconizados pelas Nações Unidas para a investigação fitoquímica de espécies produtoras de cocaína. Foi verificado que 24 espécies apresentam o aparato enzimático para a produção da cocaína. Embora E. novogranatense origina rendimentos apropriados ao tráfico, segundo a legislação Brasileira vigente, apenas E. coca encontra-se proscrita, o que torna necessário a inclusão de E. novogranatense na lista de plantas proscritas. Para o estudo toxicológico desenvolvido com E. deciduum sobre modelo de planária, foi necessário adaptar a metodologia existente. O extrato da espécie ocasionou aumento significativo da velocidade de locomoção (p= 0.016) e comportamentos estereotipados padronizados de posição tipo C e hipercinesia tipo parafuso, eventos característicos da neurotransmissão dopaminérgica em planárias. Os resultados, além de ampliar as possibilidades do uso destes vermes na busca por extratos ativos, demonstram que E. deciduum biossintetiza metabólitos ativos sobre este neurotransmissor, os quais podem estar relacionados com os efeitos ocasionados pelo consumo da espécie vegetal. A influência do período de coleta sobre as potencialidades farmacológicas e as características fitoquímicas foi investigada e os resultados demonstram esta infuência. Diferentes extratos de E. argentinum e E. deciduum, coletadas durante o verão, apresentaram atividade antimicrobiana superiores a verificada para os extratos obtidos de coletas realizadas no inverno. O extrato etanólico de E. argentinum, coleta verão, pode ser considerado um verdadeiro antimicrobiano, MIC= 0,78mg/ mL, e desta forma torna-se uma fonte promissora para a descoberta de novas moléculas antimicrobianas. Os extratos das espécies E. argentinum e E. deciduum demonstram pertinentes resultados sobre a atividade antioxidante. A influência do período de coleta, verão/ inverno, sobre a atividade foi identificada. A influência do período de coleta sobre as atividades tóxico-farmacológicas é corroborada pelo perfil alcaloídico obtido de noves espécies do gênero, coletadas durante o verão e o inverno, nos estados do Rio Grande do Sul e de Santa Catarina. O perfil alcaloídico das espécies E. amplifolium, E. argentinum, E. cuneifolium, E. cuspidifolium, E. deciduum, E. microphyllum, E. myrsinites, E. pelleterianum e E. vacciniifolium demonstra a presença dos alcaloides: éster de metecgonidina, éster de metilecgonina, cuscohigrina e tropacocaína e dos intermediários da biossíntese: higrina, tropinona e tropanol. A identificação dos metabólitos éster de metilecgonina e éster de metilecgonidina também demonstra que as espécies do gênero Erythroxylum presentes no Sul do Brasil apresentam potencialidade econômicas, pois podem ser empregadas na produção de padrões toxicológicos. Os objetivos propostos foram cumpridos e permitem concluir que espécies do gênero Erythroxylum dos estados do Rio Grande do Sul e de Santa Catarina, Sul do Brasil, demonstram importância tóxica, farmacológica e química, sendo parte destas influenciada pelo período de coleta, verão/ inverno. / “Chemical and Biological Study of Erythroxylum P. Browne Species Collected in Southern Brazil”. Erythroxylum P. Browne genus belongs to the Erythroxylaceae Kunth family and is mainly known due to E. coca and E. novogranatense species, the "coca plants". The genus is the only natural source of cocaine and other alkaloids with ecgonine nucleus, mainly responsible for the toxic and biological effects caused by the consumption of their species. The presence of cocaine is widely accepted for coca plants, but its biosynthesis by other species shows divergence, which may be related to the collect period. Besides these phytochemical peculiarities, the species of the genus also present important activities such as antioxidant and antimicrobial, besides toxicity to humans and sheep. Brazil is the center of diversity and endemism of the genus and in the south of the country, in the states of Rio Grande do Sul and Santa Catarina, the phytochemical characteristics, toxic and pharmacological potentials of the species present an open field for studies. Thus, phytochemical characteristics, toxic and pharmacological potentials of native species of the states of Rio Grande do Sul and Santa Catarina were assessed, collected in two distinct climatic periods, summer and winter, as well as a bibliographical review on cocaine producing species and implications under current Brazilian law. Some methodologies were used such as planaria, disc-diffusion in agar, microdilution in broth, extinction measurement of the absorption of cation 2,2-diphenyl-1-picrylhydrazyl and procedures recommended by the United Nations for the phytochemical investigation of cocaine producing species. It was verified that twenty-four species present the enzymatic apparatus for the production of cocaine. Although E. novogranatense originate income appropriate to traffic according to current Brazilian legislation, only E. coca is outlawed, which makes it necessary to include E. novogranatense in the list of proscribed plants. For the toxicological study developed with E. deciduum on planaria model, it was necessary to adapt the existing methodology. The extract of the species caused a significant increase in locomotion velocity (p= 0.016) and standardized stereotyped behaviors of type C position and screw- type hyperkinesia, characteristic events of dopaminergic neurotransmission in planarians. The results, besides expanding the possibilities of the use of these worms in search for active extracts, demonstrate that E. deciduum biosynthesizes active metabolites on this neurotransmitter, which may be related to the effects caused by the consumption of the plant species. The influence of the collect period on pharmacological potentials and phytochemical characteristics was investigated and the results demonstrate this influence. Different extracts of E. argentinum and E. deciduum collected during summer showed higher antimicrobial activity than the extracts obtained from winter collect. The ethanolic extract of E. argentinum, summer collect, may be considered a true antimicrobial, MIC= 0.78mg/ mL, on Staphylococcus aureus, and in this way it becomes a promising source for the discovery of new antimicrobial molecules. The extracts of E. argentinum and E. deciduum species demonstrate relevant results on antioxidant activity. The influence of the collecting period, summer/ winter, on the activity was verified. The influence of collect period on toxic- pharmacological activities is corroborated by the alkaloid profile obtained from nine species of the genus, collected during summer and winter in the states of Rio Grande do Sul and Santa Catarina. The alkaloid profile of E. amplifolium, E. argentinum, E. cuneifolium, E. cuspidifolium, E. deciduum, E. microphyllum, E. myrsinites, E. pelleterianum and E. vacciniifolium species shows the presence of alkaloids: ecgonidine methyl ester, ecgonine methyl ester, cuscohygrine and tropacocaine and the biosynthesis intermediates: hygrine, tropinone and tropanol. The identification of the ecgonine methyl ester and ecgonidine methyl ester also shows that Erythroxylum genus species present in southern Brazil have economic potential because they can be used in the production of toxicological standards. The aims were met and allow the conclusion that Erythroxylum genus of Rio Grande do Sul and Santa Catarina states, south of Brazil, show toxic, pharmacological and chemical importance, part of these being influenced by the collect period, summer/ winter.
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Estudo químico e biológico de espécies do gênero Erythroxylum P. Browne coletadas no Sul do BrasilHofmann Junior, Arno Ernesto January 2018 (has links)
O gênero Erythroxylum P. Browne pertence a família Erythroxylaceae Kunth e é principalmente conhecido devido as espécies E. coca e E. novogranatense, as “plantas da coca”. O gênero é a única fonte natural da cocaína e de outros alcaloides com núcleo ecgonina, principais responsáveis pelos efeitos tóxicos e biológicos originados pelo consumo de suas espécies. A presença da cocaína é amplamente aceita para as plantas de coca, porém a sua biossíntese por outras espécies apresenta divergência, o que pode estar relacionada ao período de coleta. Além destas particularidades fitoquímicas, as espécies do gênero também apresentam importantes atividades como antioxidante e antimicrobiana, além de toxicidade a humanos e a ovinos. O Brasil é o centro da diversidade e do endemismo do gênero e no sul do país, nos estados do Rio Grande do Sul e de Santa Catarina, as carcaterísticas fitoquímicas e potencialidades tóxicas e farmacológicas das espécies apresentam um campo aberto para estudos. Desta forma, foram avaliadas características fitoquímicas e potencialidades tóxicas e farmacológicas de espécies nativas dos estados do Rio Grande do Sul e de Santa Catarina, coletadas em dois períodos climáticos distintos, verão e inverno, além de revisão bibliográfica sobre as espécies produtoras de cocaína e as implicações segundo a legislação brasileira vigente. Foram utilizadas metodologia de planária, disco-difusão em ágar, microdiluição em caldo, medida da extinção da absorção do cátion 2,2-difenil-1-picrilhidrazil e procedimentos preconizados pelas Nações Unidas para a investigação fitoquímica de espécies produtoras de cocaína. Foi verificado que 24 espécies apresentam o aparato enzimático para a produção da cocaína. Embora E. novogranatense origina rendimentos apropriados ao tráfico, segundo a legislação Brasileira vigente, apenas E. coca encontra-se proscrita, o que torna necessário a inclusão de E. novogranatense na lista de plantas proscritas. Para o estudo toxicológico desenvolvido com E. deciduum sobre modelo de planária, foi necessário adaptar a metodologia existente. O extrato da espécie ocasionou aumento significativo da velocidade de locomoção (p= 0.016) e comportamentos estereotipados padronizados de posição tipo C e hipercinesia tipo parafuso, eventos característicos da neurotransmissão dopaminérgica em planárias. Os resultados, além de ampliar as possibilidades do uso destes vermes na busca por extratos ativos, demonstram que E. deciduum biossintetiza metabólitos ativos sobre este neurotransmissor, os quais podem estar relacionados com os efeitos ocasionados pelo consumo da espécie vegetal. A influência do período de coleta sobre as potencialidades farmacológicas e as características fitoquímicas foi investigada e os resultados demonstram esta infuência. Diferentes extratos de E. argentinum e E. deciduum, coletadas durante o verão, apresentaram atividade antimicrobiana superiores a verificada para os extratos obtidos de coletas realizadas no inverno. O extrato etanólico de E. argentinum, coleta verão, pode ser considerado um verdadeiro antimicrobiano, MIC= 0,78mg/ mL, e desta forma torna-se uma fonte promissora para a descoberta de novas moléculas antimicrobianas. Os extratos das espécies E. argentinum e E. deciduum demonstram pertinentes resultados sobre a atividade antioxidante. A influência do período de coleta, verão/ inverno, sobre a atividade foi identificada. A influência do período de coleta sobre as atividades tóxico-farmacológicas é corroborada pelo perfil alcaloídico obtido de noves espécies do gênero, coletadas durante o verão e o inverno, nos estados do Rio Grande do Sul e de Santa Catarina. O perfil alcaloídico das espécies E. amplifolium, E. argentinum, E. cuneifolium, E. cuspidifolium, E. deciduum, E. microphyllum, E. myrsinites, E. pelleterianum e E. vacciniifolium demonstra a presença dos alcaloides: éster de metecgonidina, éster de metilecgonina, cuscohigrina e tropacocaína e dos intermediários da biossíntese: higrina, tropinona e tropanol. A identificação dos metabólitos éster de metilecgonina e éster de metilecgonidina também demonstra que as espécies do gênero Erythroxylum presentes no Sul do Brasil apresentam potencialidade econômicas, pois podem ser empregadas na produção de padrões toxicológicos. Os objetivos propostos foram cumpridos e permitem concluir que espécies do gênero Erythroxylum dos estados do Rio Grande do Sul e de Santa Catarina, Sul do Brasil, demonstram importância tóxica, farmacológica e química, sendo parte destas influenciada pelo período de coleta, verão/ inverno. / “Chemical and Biological Study of Erythroxylum P. Browne Species Collected in Southern Brazil”. Erythroxylum P. Browne genus belongs to the Erythroxylaceae Kunth family and is mainly known due to E. coca and E. novogranatense species, the "coca plants". The genus is the only natural source of cocaine and other alkaloids with ecgonine nucleus, mainly responsible for the toxic and biological effects caused by the consumption of their species. The presence of cocaine is widely accepted for coca plants, but its biosynthesis by other species shows divergence, which may be related to the collect period. Besides these phytochemical peculiarities, the species of the genus also present important activities such as antioxidant and antimicrobial, besides toxicity to humans and sheep. Brazil is the center of diversity and endemism of the genus and in the south of the country, in the states of Rio Grande do Sul and Santa Catarina, the phytochemical characteristics, toxic and pharmacological potentials of the species present an open field for studies. Thus, phytochemical characteristics, toxic and pharmacological potentials of native species of the states of Rio Grande do Sul and Santa Catarina were assessed, collected in two distinct climatic periods, summer and winter, as well as a bibliographical review on cocaine producing species and implications under current Brazilian law. Some methodologies were used such as planaria, disc-diffusion in agar, microdilution in broth, extinction measurement of the absorption of cation 2,2-diphenyl-1-picrylhydrazyl and procedures recommended by the United Nations for the phytochemical investigation of cocaine producing species. It was verified that twenty-four species present the enzymatic apparatus for the production of cocaine. Although E. novogranatense originate income appropriate to traffic according to current Brazilian legislation, only E. coca is outlawed, which makes it necessary to include E. novogranatense in the list of proscribed plants. For the toxicological study developed with E. deciduum on planaria model, it was necessary to adapt the existing methodology. The extract of the species caused a significant increase in locomotion velocity (p= 0.016) and standardized stereotyped behaviors of type C position and screw- type hyperkinesia, characteristic events of dopaminergic neurotransmission in planarians. The results, besides expanding the possibilities of the use of these worms in search for active extracts, demonstrate that E. deciduum biosynthesizes active metabolites on this neurotransmitter, which may be related to the effects caused by the consumption of the plant species. The influence of the collect period on pharmacological potentials and phytochemical characteristics was investigated and the results demonstrate this influence. Different extracts of E. argentinum and E. deciduum collected during summer showed higher antimicrobial activity than the extracts obtained from winter collect. The ethanolic extract of E. argentinum, summer collect, may be considered a true antimicrobial, MIC= 0.78mg/ mL, on Staphylococcus aureus, and in this way it becomes a promising source for the discovery of new antimicrobial molecules. The extracts of E. argentinum and E. deciduum species demonstrate relevant results on antioxidant activity. The influence of the collecting period, summer/ winter, on the activity was verified. The influence of collect period on toxic- pharmacological activities is corroborated by the alkaloid profile obtained from nine species of the genus, collected during summer and winter in the states of Rio Grande do Sul and Santa Catarina. The alkaloid profile of E. amplifolium, E. argentinum, E. cuneifolium, E. cuspidifolium, E. deciduum, E. microphyllum, E. myrsinites, E. pelleterianum and E. vacciniifolium species shows the presence of alkaloids: ecgonidine methyl ester, ecgonine methyl ester, cuscohygrine and tropacocaine and the biosynthesis intermediates: hygrine, tropinone and tropanol. The identification of the ecgonine methyl ester and ecgonidine methyl ester also shows that Erythroxylum genus species present in southern Brazil have economic potential because they can be used in the production of toxicological standards. The aims were met and allow the conclusion that Erythroxylum genus of Rio Grande do Sul and Santa Catarina states, south of Brazil, show toxic, pharmacological and chemical importance, part of these being influenced by the collect period, summer/ winter.
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