No description available.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1965. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Le développement de nouvelles formes galéniques nécessite la mise au point de protocoles avec variation d’un ensemble de paramètres jouant sur les caractéristiques du dispositif. Au niveau industriel, cela représente une perte importante de temps et d’argent. Avec le développement d’outils permettant la caractérisation des systèmes et à fortiori des mécanismes impliqués dans la libération du principe actif, l’application des modèles mathématiques se voit être de plus en plus grande permettant de prédire la sortie du principe actif hors de son système. L’un des objectifs de ce travail a été de développer un modèle mathématique mécanique réaliste permettant de quantifier la libération de vitamines à partir de matrice lipidique. Deux techniques différentes de formulation : la compression directe et une suite d’extrusion en phase chauffante/ broyage/ compression directe ont permis la préparation de comprimés à base de Compritol 888 (glyceryl dibehenate NF). L’acide nicotinique a été utilisé comme principe actif modèle hautement soluble dans le milieu environnant. Des études de dissolution ont montrée une libération plus accrue pour des comprimés ayant une charge initiale en vitamine plus importante, cela liée à une augmentation de la porosité de la matrice avec l’épuisement graduel de la vitamine. Concernant la technique de préparation, un taux de sortie beaucoup plus faible dans le cas des comprimés préparés par extrusion en phase chauffante préalable, est mesuré, dû à un emprisonnement de la vitamine par la matrice fondue. A partir de ces observations et des connaissances sur les matrices lipidiques, un modèle basé sur les lois de diffusion de Fick et sur la considération de la coexistence d’une partie du principe actif sous forme dissoute ou non dissoute a été élaboré. Ce modèle permet la prédiction de la quantité de vitamine libérée au cours du temps en fonction de l’impact de la composition, de la technique de préparation et de la taille du système. Ces simulations in-silico sont d’une grande aide pour permettre d’accélérer la production de comprimés à base de Compritol 888. Dans le cas de systèmes multiparticulaires, et encore plus dans le cas de formes enrobées, des modèles mathématiques peuvent également être établis mais montrent une complexité plus grande, notamment due à la membrane polymérique. Dans cette optique, le développement de nouveaux outils pour caractériser les systèmes est primordial. Dernièrement la technologie Terahertz voit son potentiel comme nouvel outil dans la caractérisation de systèmes enrobés croissant. Son emploi dans la détection de différence de taille et d’uniformité de films polymériques d’enrobage pour des systèmes multicouches a été réalisé sur des granules de tailles conventionnelles (1mm de diamètre). Un premier enrobage de metoprolol succinate a été réalisé sur des noyaux de sucre, suivi d’un enrobage permettant le contrôle de la fuite du principe actif à base d’un mélange de Kollicoat SR :Kollicoat IR. Des granules avec différentes tailles d’enrobage ont été étudiées par Terahertz. Une taille homogène de la couche de principe actif pulvérisée a été montré dans tous les types de pellets ; alors qu’une taille croissante de l’enrobage polymérique 46 µm, 71 µm et 114 µm a pu être appréhendée. Ces résultats, mis en corrélation avec les méthodes de dissolution traditionnelles, permettront le développement d’une formule prédisant les cinétiques de libération à partir de la lecture non destructive de l’épaisseur d’enrobage par Térahertz.[...] / Development of new galenic devices needs series experiments with variation of number parameters. For industrial, it’s a lost in time and money. Food and Drug Administration initiated since several years, Process Analytical Technology (PAT) as a tool to analyze and control pharmaceutical process. These tools can be helpful to determine drug release mechanism and allow application of mathematical model to predict drug release kinetics. One objective of this work is to develop a mechanistically realistic mathematical model allowing for the quantification of vitamin release from Compritol 888 (glyceryl dibehenate NF)-based matrix tablets, prepared either by direct compression or via hot-melt extrusion/grinding/compression. Nicotinic acid has been used as highly soluble drug in surrounding medium. Dissolution studies show vitamin release rates increased with increasing initial niacin content, due to the increased matrix porosity upon vitamin depletion. In all cases, niacin release from tablets prepared via hot-melt extrusion was slower than from tablets prepared by direct compression, due to more intense embedding of the vitamin within the lipid. Importantly, a numerical model based on Fick’s law of diffusion and considering the co-existence of dissolved and non-dissolved vitamin could successfully be used to quantify vitamin release from both types of tablets, irrespective of the initial niacin loading and tablet size. In-silico simulations can be very helpful to accelerate product optimization of Compritol 888-based matrices, saving development time and costs. For multiparticulates systems, and more again for coated forms, mathematical models are more complexes. In this goal, development of new tools to characterize devices is primordial. Technology Terahertz offers an interesting potential. This technique can be used to detect difference in size and uniformity for polymeric film from multilayer pellets of 1 mm diameter. Pellets consisting of a sugar starter core and a metoprolol succinate layer were coated with a Kollicoat® SR: Kollicoat® IR polymer blend. Pellets with several coating thickness are studied. No drug layer thickness difference between batches was observed, and the average coating thicknesses were 46 µm, 71 µm and 114 µm, for the different batches. Terahertz results compared with experimental data from dissolution methods, allow predicting coating thickness results correlated with the subsequent drug release behavior. Multiparticulates systems have important interest: they allow avoiding “dose dumping”. Dose dumping is described as an unintended, rapid drug release in a short period of time of the entire amount or a significant fraction of the drug contained in a modified release dosage form (Meyer, 2005). This phenomenon can be observed in the case of ethylcellulose-based devices in presence with ethanol rich-media. Recently, ethylcellulose:guar gum blend have been reported to provide ethanol-resistant drug release kinetics from coated dosage forms. Theophylline matrix pellets were coated with ethylcellulose: guar gum blends. These granules show no change in drug release profiles upon contact with medium containing 40% of ethanol (v/v). This is because the ethanol insoluble guar gum effectively avoids undesired ethylcellulose dissolution in ethanol-rich bulk fluids. However, so far the importance of crucial formulation parameters, including the minimum amount of guar gum to be incorporated and the minimum required guar gum viscosity, remains unclear. It was found that more than 5% guar gum (referred to the total polymer content) must be incorporated in the film coating and that the apparent viscosity of a 1% aqueous guar gum solution must be greater than 150 cPs to provide ethanol-resistance. [...]

No description available.

Development of renewable energy sources such as ethanol has become a priority to meet growing energy demands. In the United States, the majority of ethanol is produced at dry mill facilities that convert corn to ethanol; these facilities can be a major emission source for volatile organic compounds (VOCs). Biofiltration is a promising VOC control technology but its effectiveness for the VOC mixtures emitted from ethanol production facilities has yet to be determined. The main goal of this research was to evaluate the feasibility of using biofiltration to treat ethanol plant air pollutants. To accomplish this, microbial degradation of four representative pollutants (formaldehyde, acetaldehyde, ethanol and acetic acid) was examined first in simplified batch reactors and then in a laboratory-scale biofilter system. The batch data indicate that, at a neutral pH, an enriched microbial consortium was capable of completely degrading formaldehyde, acetaldehyde and ethanol, and the Monod model was successfully utilized to describe single substrate degradation kinetics for these pollutants. However, the consortium only partially degraded acetic acid. In binary substrate experiments, acetaldehyde degradation was not significantly affected by either ethanol or formaldehyde. However, acetaldehyde inhibition of ethanol degradation was observed and inhibition kinetics were necessary to describe the observed ethanol removals. Formaldehyde degradation was inhibited in the presence of acetaldehyde and/or ethanol; however, further research will be required to identify the inhibtion. The biofilter study was performed to investigate the effects of pollutant loading, substrate mixtures and low pH on system performance. The results indicate that it is feasible to achieve greater than 97% overall removal efficiency at a short contact time of 5 seconds under neutral pH conditions. The level of substrate inhibition observed in the batch experiments was not evident in the biofilter experiments. However, low pH conditions gradually decreased the biofilter performance with a more significant impact on acetaldehyde, a result that was supported by batch data. Finally, a numerical model that integrated degradation kinetics was able to describe the biofilter performance under the test conditions. This research demonstrates that biofiltration has the potential to be a viable VOC treatment technology at corn-derived ethanol production facilities. / text

No description available.

No description available.

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 41-60).

The adsorption cooling technology has the potential to replace all vapor compression based chillers in the future. So, in all over the world immense researches are going on in this field. The purpose of this report is to experimentally investigate whether ethanol could serve as a refrigerant in the technology. Compared to water it has freezing point below 0 °C (-114.1 °C) and can therefore in theory be used in refrigeration applications. The report begins with the theory regarding the adsorption cooling process, describing the cycle and parameters that affect the Coefficient of Performance (COP).In the actual experiment, adsorption between the silica gel and the ethanol vapor is studied at various pressures by maintaining isothermal conditions. An experimental apparatus (Constant Volume Variable Pressure apparatus - CVVP) was fabricated, assembled and tested for this project. After the assembly and testing, volume calibration for the apparatus was carried out as it is essential to know in further experimental calculation. All the data related with the fabrication, assembly and testing of the apparatus and the volume calibrations are presented later in this report in detail.Adsorption experiments are conducted at 301.15K, 311.15K, 321.15K and 331.15K with varying inlet pressure condition to the system and then the uptake data is calculated for each and every experiments using ideal gas equation. Subsequently, the validations of the experimental data with the standard adsorption isotherms are done. Dubinin-Astakhov is found to be the most ideal isotherm to simulate the theoretical data. Its RMSE (Root Mean Square Error) value is found to be 0.506%. It is concluded that ethanol valid option for refrigeration, but further research is needed and recommended.

Environmental and political concerns centered on energy use from gasoline have led to a great deal of research on ethanol production. The goal of this thesis is to determine if it is profitable to produce ethanol in Texas using sweet sorghum juice. Four different areas, Moore, Hill, Willacy, and Wharton Counties, using two feedstock alternatives, sweet sorghum only and sweet sorghum and corn, will be analyzed using Monte Carlo simulation to determine the probability of economic success. Economic returns to the farmers in the form of a contract price for the average sweet sorghum yield per acre in each study area and to the ethanol plant buying sweet sorghum at the contract price will be simulated and ranked. The calculated sweet sorghum contract prices offered to farmers are $9.94, $11.44, $29.98, and $36.21 per ton in Wharton, Willacy, Moore, and Hill Counties, respectively. The contract prices are equal to the next most profitable crop returns or ten percent more than the total cost to produce sweet sorghum in the study area. The wide variation in the price is due to competing crop returns and the sweet sorghum growing season. Ethanol production using sweet sorghum and corn is the most profitable alternative analyzed for an ethanol plant. A Moore County ethanol plant has the highest average net present value of $492.39 million and is most preferred overall when using sweet sorghum and corn to produce ethanol. Sweet sorghum ethanol production is most profitable in Willacy County but is not economically successful with an average net present value of $-11.06 million. Ethanol production in Hill County is least preferred with an average net present value of $-712.00 and $48.40 million when using sweet sorghum only and sweet sorghum and corn, respectively. Producing unsubsidized ethanol from sweet sorghum juice alone is not profitable in Texas. Sweet sorghum ethanol supplemented by grain is more economical but would not be as profitable as producing ethanol from only grain in the Texas Panhandle. Farmers profit on average from contract prices for sweet sorghum when prices cover total production costs for the crop.