The influence of symmetry breaking on the flow induced oscillations of bluff bodies in the steamwise direction is studied. First, a series of experiments is conducted on a one-degree-of-freedom circular cylinder allowed to exhibit pure translational motion in the streamwise direction over a range of reduced velocities, 1.4 < U* < 4.4, corresponding to a Reynolds number range of 970 < Re < 3370. Two distinct regions of displacements were observed in reduced velocity ranges of 1.6 < U* < 2.5 and 2.75 < U* < 3.85. Measured force coefficients in the drag and lift direction were examined, along with the wake visualization, through the range of reduced velocities, to infer the resulting wake modes. A new Alternating Symmetric (AS) mode was found. This transition from symmetric to AS shedding occurred near the end of the first region of response. Similar tests were run with a square prism in the parameter space of 2.4 < U* < 5.8 and 757 < Re < 1900 over angles of incidence of 0° ≤ α ≤ 45°. A distinct region of lock-in is observed for α = 0°, 2.5°, 5°, 7.5° over 3.2 < U* < 5.4 for α = 0°, and decreasing with increasing α. The wake structures were found to be roughly symmetric for α = 0°, but transitioned towards asymmetry with increasing α. For α = 0° and 2.5° a gradual increase in the asymmetry of the fluid forcing was observed with increasing U*, similar to the circular cylinder.

This thesis presents a procedure to collect, process, and analyse data for use in machine learning models within the rifle marksmanship domain. The machine learning model, features, and analysis presented in this thesis provide a first step towards models that can provide automated assistance for rifle marksmanship practice.A quasi-experiment is designed with eye movement and rifle handling as independent variables, and shooting result as dependent variable. The data is collected by letting 14 participants with different levels of marksmanship experience perform a rifle shooting exercise. Eye movement data is gathered using a Tobii Pro Glasses 3 eye tracker, and rifle handling data is gathered using an iCubeX Orient3D IMU. Analysis from the data shows a stratification of participant rifle marksmanship experience into five classes. The highest performing group, to a larger degree than the other groups, aimed with both eyes open, has a faster rifle acceleration, has a lower time between peak motion and shot, and are overall more consistent with their shots. A prototype random forest classification model trained to predict these classes shows a Cohen’s Kappa of 0.526, balanced accuracy of 0.599 and a one-vs-all AUC between 0.83 and 0.95 for the classes.

The theses entitled "Radio newscast: specific features of auditive dissemination of information" deals with the influence of the lucidity of the radio newscast language on the volume of verbal sound information absorbed by the listener. Applying the method of psychological experiment it is examined whether the listeners can remember texts written according to the principles of radio writing better than texts in the factual style of the news of the Czech Press Agency. The issue addressed is set in the context of the current research in the field of media studies. The paper also offers a survey of experiments used for radio audience research. The thesis also includes a brief history of the radio newscast in the Czech lands focused, above all, on the sources of information used and the language applied.

Indiana University-Purdue University Indianapolis (IUPUI) / Suboptimal dosing of anti-microbial agents increases the likelihood of therapeutic failure and resistance. Dosing optimization, while an attractive approach to combat these issues, is difficult to implement due to the different pharmacokinetics of each individual. These limitations highlight the inadequacies of a “standardized” dosing strategy. Therapeutic drug monitoring (TDM) provides a tailored treatment for individuals while avoiding adverse side effects from compounds with a narrow therapeutic window where elevated concentrations of a drug cause organ toxicity. This strategy involves accurately measuring the concentration of the analyte and interpreting the results based on pharmacokinetic parameters. Clinicians then draw conclusions regarding dose adjustment for their patient. However, TDM is expensive and difficult to perform because measurements occur in biofluids. Rapid and robust methods are necessary to quantify antimicrobial agents at the institutional level to guide patient care toward improved outcomes in serious infection. Paper spray ionization (PS), an emerging ambient ionization technique for clinical settings, demonstrations a wide versatility both in analyte variety and applications. This technique offers a rapid, accurate method to analyze these compounds with low rates of false positives even when multiplexing. The work herein explains the method development of assays for TDM of various antimicrobial agents. Chapters two and three describe ways to improve the quantitative capability of paper spray through substrate pre-treatment, modification, and manipulation of key factors. Chapter four describes real-world applications for paper spray utility in clinical settings with the cross-validation of antifungal agents against a “gold standard” method. The final chapter, while not clinical based, describes the method development process for a LC-MS/MS assay to detect urobilinoids in fly guts.

This work solves the effect of incorrect tire inflation on the warming of their parts while driving a personal car. A series of tests were carried out for different tire pressure values and during the tests the temperature data of tires was collected using a thermocamera. An analysis of these data was also carried out and a proposal for modification of the methodology for further measurements was made.

Master’s thesis focuses on the history and current progress in research of molten salt reactors around the world, with an emphasis placed on the properties of molten salts and the problems associated with their use. In relation to the practical part, one chapter is devoted to the creation of input file in the MCNP software. The practical part deals with neutron activation analysis of graphite prism experiment, which is filled with powder NaCl salt. This experiment is focused on the effect of salt on neutron flux with different energy levels. The whole problem was also simulated in the MCNP environment along with the experiment. At the end of the thesis, the individual methods are compared and evaluated.

The aim of work is to present and analyse assessment of the current state and at the same time the proposal of adjustments to the technology or parameters, the introduction of the wire into the drawing machine. The problem arises when the introduction of wire with a diameter of 14 mm from the material CK 67 to the drawbenches Schumag. If we introduce the wire into the drawing machines with two primary beams leads to a buckling of the wire and pack between the drawing die and the boot device. For the introduction of wire are used hydraulic boot collets, which are controlled semi-automatically. In connection with professional studies and on the basis of the calculation, simulation and practical experiment have been identified the conditions allowing the current method of deployment of wire to use.

The diploma thesis deals with the influence of the volumetric accuracy of the machine tool on the size of the assessed work space. The impact assessment was carried out on the basis of tests of a three-axis vertical CNC machining center. The thesis is divided into two parts, theoretical and practical. The theoretical part is focused on geometric / volumetric accuracy of machine tools, measuring technique for measuring geometric errors and Design of Experiment. In the practical part, there is an analysis of the Design of Experiment according to Shainin, description of the work with the measuring instruments and the measurement of the geometric / volumetric accuracy of the machine including statistical evaluation. The output of the thesis is the description of the influence of volumetric deviation on the size of the measured work space by means of statistical methods.

This master thesis deals with inhalation of fine particles and fibres into human lungs. This is a scientific field where computer modelling is used to describe the movement of fibres and their deposition in the lungs. However, the results of these simulations must be verified experimentally. The prediction of fibres behaviour is important from a toxicology point of view where it is important to know deposition hot-spots and places where fibres could possibly cause problems. The review of the state-of-the-art is focused on the deposition of particles in human lungs followed with a chapter on fibre as a type of particle, and occupational exposure limits set by different world associations. The last theoretical chapter describes human lungs and its diseases which can evolve when limits for occupational exposure are not met. The experimental chapter consists of a description of the used experimental setup and results from an experiment together with a comparison of results with other similar experiments.

The Diploma thesis describes the implementation of innovative production of protective liner to the manufacturing company. The liner is manufactured in sizes of nominal diameter DN 200 - DN 500. The material is low-alloy steel EN 10216-2 10CrMo9-10. For the production innovation, the technology of pipe end flaring by a movable mandrel was chosen. Verification of the functionality of this technology was performed using analytical calculations and numerical simulation of FEM. The results of numerical methods were compared with the results of a practical experiment. The experiment was performed on 5 test specimens with a diameter of 273 mm. The machine device was a hydraulic press with a nominal force of 2000 kN and equipped with pressure and position sensors. The experimentally obtained values of force and the tool path dependence were similar with the values of FEM simulation. The difference in the value of the force in the maximum tool path was 290 kN. The flared diameter was formed to a value of 319 mm. This value corresponds to 16.5% of increased nominal diameter, which is sufficient from design point of view. Non-destructive tests ruled out the presence of crack defects on the flared diameter. According the new set up working procedure was produced the first real part. Significant financial savings of CZK 3.5 - 5.3 million / year were quantified in the technical and economic evaluation. Return on necessary investments is between the 9th - 14th manufactured pieces (approx. 15% of the annual production volume). In conclusion, innovation has promising results and will be issued by the company into the production process.