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<p><strong>Objective: </strong>The objective of this thesis is to identify the approaches to patient-centered care provision currently employed by clinicians and to identify patient perspectives of patient-centeredness in relation to pain and disability following distal radius fracture. This thesis includes a scoping review of patient-centered care frameworks and models, as well as a prospective cohort study.</p> <p><strong>Rationale: </strong>Patient-centered care provision has been linked with positive health outcomes, improved patient satisfaction, and reduced health costs. A uniform approach to patient-centered care in rehabilitation has yet to be developed primarily due to the breadth and scope of practice. Understanding current approaches to patient-centered care and patient perspectives on this care can serve as a foundation to future discussions on the development of a rehabilitation-specific approach to patient-centered care provision.</p> <p><strong>Data sources: </strong>Frameworks and models of patient-centered care provision were located via electronic database searches. The extracted frameworks and models were compared based on how they described strategies on achieving the three tenets of patient-centered care: communication, partnership, and health promotion. A prospective cohort study provided patient perspectives on patient-centeredness, pain, and disability following distal radius fracture at baseline and at three months post distal radius fracture in 129 patients.</p> <p><strong>Methods: </strong>Frameworks and models on patient-centered care provision were extracted from articles and placed in data summary tables for comparison and review. Information on how these frameworks and models described strategies for communication, partnership, and health promotion was collated and reviewed. The patients’ perceptions of patient-centeredness, pain, and disability were determined from responses to the Patient Perceptions of Patient-Centeredness Questionnaire and the Patient Rated Wrist Evaluation. Outcome measure responses were analyzed to measure change over time (Wilcoxon Rank Sum and T-Test analyses) and to identify relationships (Pearson correlations).</p> <p><strong>Results: </strong>The scoping review found 19 articles, from which 25 patient-centered care frameworks or models were identified. All frameworks and models reported strategies on achieving effective communication, partnership, and health promotion. The prospective cohort study revealed significant correlations between patient perspectives of patient-centeredness and pain and disability following distal radius fracture. This suggests that positive experiences with patient-centered care provision are correlated with reduction in pain and improvement in function following an acute orthopaedic injury.</p> <p><strong>Implications: </strong>Until a rehabilitation-specific approach to patient-centered care provision is developed, rehabilitation clinicians can be confident that selection of one of the currently employed frameworks or models of patient-centered care will reflect the three tenets of patient-centered care provision. Adopting one of these patient-centered approaches to care provision likely will result in positive health outcomes.</p> / Master of Science Rehabilitation Science (MSc)

<p><strong>Background:</strong> Despite strong evidence, strategies for improving bone health are underutilized. Knowledge translation (KT) interventions aim to improve uptake of evidence-based practices, however the feasibility and effectiveness of such strategies require further evaluation within Long-term Care (LTC). In this thesis, we examined the impacts of a province-wide osteoporosis strategy and a more intensive multifaceted KT strategy including expert-led educational meetings, audit/feed-back, and action planning for quality improvement. Both studies targeted interdisciplinary LTC teams (physicians, nurses, pharmacists, dietician, and other staff).</p> <p><strong>Methods: </strong>In the first thesis study, we examined the impact of the <em>Ontario Osteoporosis Strategy for LTC</em> by investigating changes in facility-level prescribing rates (vitamin D, calcium, osteoporosis medications) before and after its implementation (2007 versus 2012). The second study was a pilot cluster randomized trial evaluating the feasibility and effectiveness of a 12-month, multifaceted, interdisciplinary KT intervention [Vitamin D and Osteoporosis Study (ViDOS)]. Prescribing outcomes included: vitamin D ≥800 IU (primary), calcium ≥500 mg/day, and osteoporosis medications (high-risk residents only). Feasibility outcomes included recruitment, retention, data collection, intervention fidelity, and process changes. We analyzed resident level data using the generalized estimating equations (GEE) technique, adjusting for clustering.</p> <p><strong>Results:</strong></p> <p>In both studies, significant improvements were observed for vitamin D and calcium prescribing. In the first study, prescribing increased by 38% and 4%, respectively, between 2007 and 2012. In the ViDOS trial, the 12-month intervention resulted in an absolute improvement of 15% and 7%, respectively (intention to treat cohort). There was no significant effect for prescribing of osteoporosis medications in either study. In the ViDOS study, recruitment and retention rates were 22% and 63%, respectively; good intervention fidelity was achieved and intervention homes reported several process changes.</p> <p><strong>Conclusion:</strong></p> <p>This thesis study demonstrated that KT interventions targeting evidence-based osteoporosis and fracture prevention strategies were feasibly and effectively applied with interdisciplinary LTC teams.</p> / Doctor of Philosophy (PhD)

Long-term repercussions of extremity trauma can include fracture mal- and non-union, osteoarthritis, pain, and impairment of physical movement, which can result in disuse of the limb and eventual bone loss. Although trauma is commonly investigated in palaeopathology, the functional repercussions of injuries are not typically considered. By integrating palaeopathological fracture analyses and biomechanical investigations of cross-sectional properties, this thesis explores individual and group experiences of extremity fracture risks, responses, and consequences at two Roman sites. Adults from 1st-4th century AD Roman cemeteries at Ancaster, UK (n=181), and Vagnari, Italy (n=66), were examined for limb fractures. Data on fracture type, location, malunion, and associated infection and osteoarthritis were collected. Bone areas and asymmetries were calculated using biplanar radiographs for individuals without fractures, and compared to those of individuals with fractures. Patterns in bone amounts and asymmetries associated with fracture attributes were identified. Extremity fractures were observed in 39 individuals from Ancaster and 12 individuals from Vagnari, but the prevalence rates did not differ between the sites. Cross-sectional properties suggested that compared to Ancaster, individuals living at Vagnari experienced greater mechanical loading (i.e., larger bone areas). Disuse of a fractured limb was only identified in two old adult individuals from Ancaster; no Vagnari individuals had evidence for post-traumatic dysfunction. Functional consequences of injuries were not associated with observable fracture attributes (e.g., fracture type, malunion), meaning that physical impairment cannot be recognized based only on an injury’s appearance. By incorporating biomechanical methods in palaeopathological analyses of trauma, this thesis reveals the physical experiences of injury acquisition and recovery among residents of Ancaster and Vagnari over the life course. The relative absence of post-traumatic disuse speaks to the resilience of Romans at these sites, and contributes to the growing literature on the human experience of trauma and impairment in the past. / Thesis / Doctor of Philosophy (PhD) / Immobility and disuse of a fractured arm or leg can result in bone loss. Using radiographs, this research evaluated physical activity and long-term fracture complications in adult skeletons from ancient Roman communities at Ancaster, UK and Vagnari, Italy (1st-4th century AD). Compared to Ancaster, Vagnari individuals had thicker bones that indicated they were more physically active. Evidence for physical consequences were not associated with the type or location of a fracture; only two individuals from Ancaster (and none from Vagnari) had evidence of disuse. This study of fracture consequences contributes to our understanding of injury risk and recovery in the past. Although fractures can cause lasting physical consequences, these results show that fractures that appeared ‘severe’ did not necessarily result in long-term impairment. Most residents at Ancaster and Vagnari were physically active and recovered from their injuries, a finding that emphasizes the importance of continued physical activity after injury.

Fracture systems or networks always control the stability, deformability, fluid and gas storage capacity and permeability, and other mechanical and hydraulic behavior of rock masses. The characterization of fracture systems is of great significance for understanding and analyzing the impact of fractures to rock mass behavior. Fracture trace data have long been used by engineers and geologists to character fracture system. For subsurface fractures, however, boreholes, wells, tunnels and other cylindrical samplings of fractures often provide high quality fracture trace data and have not been sufficiently utilized. The research work presented herein is intended to interpret fracture traces on borehole walls and other cylindrical surfaces by using stereology. The relationships between the three-dimension fracture intensity measure, P32, and the lower dimension fracture intensity measures are studied. The analytical results show that the conversion factor between the three-dimension fracture intensity measure and the two-dimension intensity measure on borehole surface is not dependent on fracture size, shape or circular cylinder radius, but is related to the orientation of the cylinder and the orientation distribution of fractures weight by area. The conversion factor between the two intensity measures is determined to be in the range of [1.0, &#960;/2]. The conversion factors are also discussed when sampling in constant sized or unbounded fractures with orientation of Fisher distribution. At last, the author proposed estimators for mean fracture size (length and width) with borehole/shaft samplings in sedimentary rocks based on a probabilistic model. The estimators and the intensity conversion factors are tested and have got satisfactory results by Monte Carlo simulations. / Ph. D.

Yes / More than 2 million people/year suffer a bone fracture in the UK1. Reconstruction of bone defects represents a major clinical challenge and is addressed using a number of medical devices. Although medical device compositions and applications may differ widely, all attract microorganisms and represent niches for medical device associated infections. For open fractures, the risk of infection can be 55%2. These infections are often resistant to many of the currently available antibiotics and represent a huge and growing financial and healthcare burden. The aim of this study was a fundamental understanding of how the presence of host defence peptides (HDPs)3 and/or RGD can influence the outcome of cell vs. bacterial viability and proliferation. / Presented at the conference: eCM XVI - Bone and Implant Infection June 24-26, 2015, Convention Centre, Davos Platz, Switzerland.

Peu de données sont disponibles quant à l’utilisation des services de santé par les personnes âgées fragiles ayant subi une fracture. Actuellement, cette information provient principalement d’études de cohortes ou d’essais cliniques. Dans de telles études, la fragilité est généralement mesurée à l’aide d’indices ou d’échelles cliniques. Ces mesures ne sont généralement pas incluses dans les bases de données administratives disponibles pour la prise de décision, la surveillance ou la recherche populationnelle. Cependant, avec l’augmentation attendue des ressources de santé liées à la fragilité, les méthodes pour identifier les aînés fragiles dans ces bases de données sont prioritaires. Nous avons donc conduit une étude de cohorte populationnelle pour décrire et identifier les services de santé utilisés par cette population après une consultation médicale pour une fracture mineure. Les objectifs de cette étude étaient d’évaluer la prévalence de la fragilité des aînés ayant subi une fracture mineure dans les bases de données administratives de santé du Québec, d’examiner la relation entre la fragilité et l’utilisation des services de santé dans l’année qui a suivi la consultation médicale pour cette fracture et de mesurer l’excès de la consommation des services de santé suivant la fracture récente. Il existe de nombreuses raisons de mesurer la fragilité, incluant l’identification des personnes présentant un risque accru de problèmes de santé. Cette étude populationnelle suggère que les personnes âgées identifiées comme fragiles par l’«Elders Risk Assessment index» et qui sont victimes de fractures même mineures utilisent davantage les services de santé dans l’année suivant leur fracture. Cette utilisation des bases de données administratives du Québec indique que, dans une perspective de santé publique, il est possible de les utiliser pour la surveillance de la fragilité et de ses conséquences pour les personnes âgées. / Few data are available on the use of health services of frail elderly people who have experienced a minor fracture. Currently, information on the identification of frail seniors and on their health resources needs and use mostly comes from cohort studies or from clinical trials. In such studies, frailty is generally measured using clinical indices or scales, which are not included in population-based high-quality administrative databases available for decision-making, population surveillance or research. However, given the expected increase in frailty-related health resources-use associated with population ageing, methodologies to identify frail seniors within such secondary healthcare data, both at patient and population levels, are current surveillance priorities. We therefore conducted a population-based cohort study to describe and identify health services use by this population after a medical consultation for a minor fracture. The objectives of this study were to assess the prevalence of frailty among community-dwelling seniors who sustained a recent non-hip fracture in Quebec health administrative databases, to examine the association between frailty and the use of medical services in the year following the fracture and to measure the excess use of health services following that fracture across frailty levels. There are many reasons to measure frailty, including identification of people who are at an increased risk of adverse health outcomes. This population-based study suggests that seniors identified as frail by the Elders Risk Assessment index and sustaining relatively minor fractures use more health services in the year post-fracture. This first use of Quebec’s administrative databases indicates that, in a public health perspective, it might be possible to use them for surveillance on frailty and its consequences among seniors.

INTRODUÇÃO: A redução cirúrgica e fixação rígida por meio do acesso retromandibular transparotídeo vem se difundindo como uma das opções para o controverso tratamento das fraturas de côndilo mandibular. OBJETIVOS: Avaliar o tratamento cirúrgico pela via retromandibular transparotídea das fraturas extracapsulares de côndilo mandibular em adultos. MÉTODOS: Foram avaliados retrospectivamente dez pacientes consecutivos operados pelo autor no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Todos eram adultos com fraturas extracapsulares de côndilo mandibular causando encurtamento maior que 2 mm ou desvio maior que 10 graus. Os pacientes foram operados por meio do acesso retromandibular transparotídeo e tiveram suas tomografias pré e pós-operatórias avaliadas por meio de reconstrução tridimensional. A qualidade da redução quanto ao posicionamento no foco de fratura foi classificada como ideal, satisfatória ou pobre. Em sete pacientes com fraturas unilaterais, os lados não fraturados serviram como controles em uma avaliação quantitativa do posicionamento da cabeça condilar. As variáveis altura condilar e inclinações sagital, coronal e axial foram medidas nas tomografias pré e pós-operatórias para os lados fraturados e não fraturados. As diferentes medidas foram comparadas entre si. Quanto à morbidade do acesso, foram avaliadas: assimetrias na mímica facial, incidência de fístulas salivares ou infecções e qualidade das cicatriz. Com pelo menos 18 meses após a cirurgia, os pacientes foram convocados para uma avaliação do pós-operatório tardio. Foram questionados quanto a presença de estalidos articulares, limitação da abertura oral, dor facial e mastigação insatisfatória. A situação referida no pós-operatório tardio foi comparada referida para o período anterior ao trauma. Os pacientes foram examinados em busca de estalidos ou dor à palpação facial, intercuspidação não corrigida, desvio à abertura oral, limitação à protrusão ou à lateralidade. A abertura oral máxima foi quantificada. RESULTADOS: No foco de fratura, a redução foi classificada como satisfatória ou ideal em nove pacientes. Quanto ao posicionamento da cabeça condilar, para as variáveis altura condilar e inclinação coronal, no pré-operatório, houve diferença estatística entre os lados fraturados e os lados normais. No pós-operatório, não houve diferença para nenhuma das variáveis na comparação entre os lados fraturados e os não fraturados. Não foram observadas assimetrias na motricidade da mímica, fístulas salivares ou infecção desde o pós-operatório imediato. Uma paciente apresentou cicatriz hipertrófica. No pós-operatório tardio, encontraram-se abertura oral máxima entre 39 e 55 mm, desvio à abertura oral em um paciente e surgimento de estalidos em dois, o que não se mostrou estatisticamente diferente do período anterior ao trauma. CONCLUSÕES: O tratamento aberto por via retromandibular com redução e fixação rígida de fraturas extracapsulares de côndilo mandibular com desvio ou encurtamento em adultos é capaz de prover correção da anatomia condilar com baixa morbidade relacionada ao acesso e com evolução funcional satisfatória. / INTRODUCTION: Open reduction and rigid internal fixation through retromandibular transparotid approach has been increasingly accepted as one of the options for treatment of fractures of the mandibular condyle, which is still a controversial subject. OBJECTIVES: To evaluate surgical treatment through retromandibular transparotid approach for extracapsular fractures of mandibular condyle in adults. METHODS: Ten consecutive patients operated on by the author at University of São Paulo Medical School Hospital were retrospectively evaluated. All of them were adults with extracapsular fractures of mandibular condyle causing shortening greater than 2 mm or deviation greater than 10 degrees. Patients were operated through retromandibular transparotid approach and had their pre and postoperative CT scans assessed with tridimensional reconstruction. Quality of reduction at fracture site was classified as optimal, satisfactory or poor. In seven patients with unilateral fractures, non-fractured sides served as controls in quantitative assessment condylar head positioning. Variables condylar height and sagittal, axial and coronal inclinations were measured in preoperative and postoperative CT scans, on fractured and not fractured sides. The different measures were compared. On morbidity of the approach, were evaluated: facial animation asymmetry, incidence of salivary fistula or infection and quality of scar. At least 18 months after surgery, patients were called for an assessment of postoperative period. They were asked about the presence of clicking joints, limitation on mouth opening, facial pain and poor mastication. Situation at postoperative period was compared with the one previous to trauma. Patients were examined for clicking or pain on palpation, uncorrected intercuspation, chin deviation on mouth opening and limitation on protrusion or laterality. The maximum mouth opening was measured. RESULTS: At the fracture site, reduction was rated as satisfactory or ideal in nine patients. As for the positioning of the condylar head, for the variables height and coronal condylar inclination, preoperatively, there was statistical difference between fractured and normal sides. Postoperatively, there was no difference for any variable when comparing fractured and normal sides. There were no asymmetries in facial animation, salivary fistula or infection since immediate postoperative period. One patient had hypertrophic scar. In the late postoperative period, were found: maximum mouth opening between 39 and 55 mm, chin deviation at oral opening in one patient and the emergence of clicking in two, data that was not statistically different from the period before the trauma. CONCLUSIONS: Treatment of shortened or deviated extracapsular fractures of the mandibular condyle in adults by open reduction and rigid internal fixation through retromandibular transparotid approach can provide correction of condylar anatomy with low morbidity and satisfactory functional outcome

O objetivo deste trabalho foi comparar radiografias periapicais (RP) com quatro protocolos diferentes de tomografia computadorizada por feixe cônico (TCFC) para o diagnóstico de fraturas alveolares e radiculares. Oitenta incisivos superiores (40 hígidos e 40 com fratura radicular) de cães foram inseridos em 80 alvéolos anteriores (40 hígidos e 40 com fratura alveolar) de 20 maxilas caninas maceradas em posições randomizadas previamente. Cada maxila foi submetida a duas RP com diferentes angulações verticais e a quatro protocolos de TCFC com variações em kV (72 kV ou 80 kV), mA (4 mA ou 8 mA) e número de projeções (400 ou 500). As imagens obtidas foram randomizadas e analisadas por dois radiologistas odontológicos por duas vezes, com um intervalo de duas semanas entre as observações. Valores de sensibilidade, especificidade e acurácia para as análises binárias foram melhores para TCFC do que RP; fraturas radiculares apresentaram melhores resultados corretos de diagnóstico do que fraturas alveolares para RP e TCFC. Para a verificação da acurácia através da área sob a curva (ASC) de característica de operação do receptor (ROC), resultados de TCFC foram melhores do que resultados de RP; fraturas radiculares apresentaram melhores resultados corretos de diagnóstico do que fraturas alveolares para RP e TCFC. Quando a localização da fratura alveolar (porção vestibular ou porção palatina do alvéolo) ou da fratura radicular (terço cervical, médio ou apical) foi levada em consideração para a realização das análises estatísticas, os mesmos apresentaram uma discreta redução. RP com duas angulações verticais diferentes podem ser consideradas um bom método para diagnosticar fraturas radiculares. Quando não é possível diagnosticar fraturas radiculares e alveolares em RP, o próximo exame de escolha é a TCFC. / The purpose of this study was to compare periapical radiograph (PR) and four different protocols of cone-beam computed tomography (CBCT) in the diagnosis of alveolar and root fractures. Eighty incisor teeth (40 higid and 40 with root fracture) from the canine species were inserted in 80 anterior alveolar sockets (40 higid sockets and 40 sockets with alveolar fracture) of 20 macerated canine maxillae in previously randomized positions. Afterwards, each maxilla was submitted to periapical radiograph in two different vertical angulation incidences, and to four different CBCT protocols, with variations in kV values (72 kV or 80 kV), mA values (4 mA or 8 mA) and number of frames (400 ou 500). The images were randomized and posteriorly analyzed by two oral and maxillofacial radiologists two times, with a two-week interval between observations. Sensitivity, specificity and accuracy values for binary analyses were better for CBCT than for PR; root fractures showed better diagnosis results than alveolar fractures for both CBCT and PR. When accuracy was calculated through area under the receiver operating characteristic (ROC) curve, CBCT showed better results than PR; root fractures showed better diagnosis results than alveolar fractures for both CBCT and PR. There was a slight reduction in value results when we considered the alveolar fracture (buccal or palatine portion of alveolus) or root fracture (cervical, median or apical third) location to perform the statistical analyses. Periapical radiograph with two different vertical angulations may be considered an accurate method to detect root fractures. When no fractures are diagnosed in PR and the patient describes pain symptoms, the subsequent exam of choice is CBCT.