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New Strategies for the functionalization of N-heterocycles using Li-, Mg- and Zn-organometallicsBarl, Nadja Maria 26 June 2014 (has links) (PDF)
The first part of this work focused on the development of a convenient and general regioselective functionalization of all ring positions of the 7-azaindole scaffold. To this end, starting from simple 2-amino-5-bromopyridine an appropriately substituted azaindole precursor was prepared which allowed us to functionalize the 7-azaindole ring in a predictable manner using a combination of directed metalation, halogen/magnesium and sulfoxide/magnesium exchange. Furthermore, the general preparation of various heteroarylmethylzinc reagents by LiCl-promoted zinc insertion into the corresponding chloromethyl heteroarenes, along with a facile and straightforward synthesis of these chloromethyl precursors displayed a major part in this work. The obtained zinc compounds were subjected to Pd-catalyzed cross-couplings, Cu-mediated acylations, Cu-catalyzed allylations and addition reactions to aldehydes. In addition, they proved to be versatile intermediates for the construction of fused N- and O-heterocycles and gave access to an analogue of a reported CB1 modifier. Finally, a lithiation/transmetalation strategy for the metalation of sensitive functionalized arenes and heteroarenes was developed, using the strong amide base TMPLi in the presence of metal salts such as ZnCl2, MgCl2, CuCN and LaCl3. This in situ trapping method not only allowed the metalation and functionalization of sensitive heteroarenes, but also provided metalated intermediates with a different regioselectivity to the one produced with moderately powerful bases such as TMPZnCl•LiCl or TMPMgCl•LiCl, giving access to higly functionalized organometallics difficult to prepare otherwise.
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Defined nanocarriers for improved and targeted gene deliveryKos, Petra 24 July 2014 (has links) (PDF)
No description available.
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Contribution of RNA binding proteins to substrate specificity in small RNA biogenesisFesser, Stephanie Marion 02 July 2013 (has links) (PDF)
No description available.
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Investigation of the role and regulation of modified DNA and RNA nucleosidesBrandmayr, Caterina 11 February 2014 (has links) (PDF)
No description available.
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Targeting cyclin dependent kinase 5 in hepatocellular carcinomaEhrlich, Sandra Monika 25 July 2014 (has links) (PDF)
For a long time cyclin dependent kinase 5 (Cdk5) was thought to be of exclusive importance in neuronal cells. However, recently increasing evidence suggests a function of Cdk5 in cancer progression. In the present study, we examined the role of Cdk5 in hepatocellular carcinoma (HCC), a highly chemoresistant cancer with poor prognosis. Consequently, development of novel targeted therapies for HCC is of paramount clinical importance. Analysis of human HCC patient samples showed an increased expression of Cdk5 as compared to normal liver tissues. Functional ablation of Cdk5 significantly decreases HCC cell proliferation and clonogenic survival, and reduces cell motility and invasion. Of note, genetic as well as pharmacologic inhibition of Cdk5 also shows in vivo efficacy in a HCC xenograft mouse model. Investigating the mechanism behind these functional effects revealed that Cdk5 is most active in the nucleus of cells in G2/M phase. In this cell cycle phase DNA damage response takes place, which is affected by Cdk5 inhibition. Furthermore, Cdk5 leads to phosphorylation of Ataxia Telangiectasia Mutated (ATM) and thereby influence its downstream signaling. Importantly, combination of Cdk5 inhibition with different DNA damage inducing chemotherapeutics or the first-line systemic drug sorafenib inhibits synergistically HCC tumor progression.
In conclusion, we introduce:
1. Cdk5 as a novel drugable target for treatment of HCC
2. The combination of Cdk5 inhibition and DNA damage agents as a novel therapeutic approach
3. An increased efficacy of sorafenib treatment by combing with Cdk5 inhibition
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Synthesis route for ultra-small nanoparticles for energy applicationsFeckl, Johann 11 June 2013 (has links) (PDF)
No description available.
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Periodic mesoporous organosilicas with functional chromophoresLi, Yan 19 July 2012 (has links) (PDF)
No description available.
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Global analysis of mRNA metabolism by comparative dynamic transcriptome analysisSun, Mai 28 May 2013 (has links) (PDF)
No description available.
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Single molecule microscopyDavies, Eva Melari 23 July 2013 (has links) (PDF)
No description available.
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Synthesis, thermal behavior and thermoelectric properties of disordered tellurides with structures derived from the rocksalt typeSchröder, Thorsten 17 June 2014 (has links) (PDF)
No description available.
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