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This thesis explores the settlement of the Mississippi Territory through the eyes of John Hailes, a Southern yeoman farmer, from 1813 until his death in 1859. This is a family history. As such, the goal of this paper is to reconstruct John’s life to better understand who he was, why he left South Carolina, how he made a living in Mississippi, and to determine a degree of upward mobility. Local, state, and federal government records provide the general context of this study and accurately track John’s movements and land purchases within the territory. John's frequent movements and the land he bought suggest that he was a herder and relied on hogs and cattle for a living. This contextual biography suggests that John was mobile, that he was sensitive to land policies and market pressures, and that he maintained a yeoman's standard of living throughout his life.

Family genealogy research has grown exponentially over the past decade, making it an area worthy of scholarly inquiry (Smith, 2010). Genealogy is now one of the world's most popular hobbies, with hundreds of millions of people worldwide actively engaged in some form of family research (Veale, 2004). In the United States, there has recently been a significant increase in the interest of searching out one's genealogical roots (Triseliotis, 1998). For most young people, the years from late teens to early twenties represent a period of profound change (Arnett, 2000). Many young adults search for and solidify their identity during the years they attend college (Muuss, 1996). Few research studies have examined the experience of searching one's genealogy and the impact it might have on college student development. This study focused on the experiences of college students who were searching their own personal ancestry in an undergraduate class on family history/genealogy. Participants reported that researching their family history (a) ignited or intensified a strong interest in genealogical research, (b) developed connections, closeness, and bonds to ancestors which motivated them in their lives, (c) discovered shared physical and personality characteristics, (d) impacted their current relationships with living relatives, (e) stimulated spiritual experiences, and (f) influenced their identity development.

BACKGROUND: Polygenic risk scores (PRS) have emerged as a promising tool for predicting the risk of developing a variety of illnesses, including psychiatric disorders. PRS are calculated by analyzing the genetic variants across the genome to assess an individual’s risk for developing a disorder. Family history (FHx) of psychiatric disorders has long been recognized as a valuable tool in assessing an individual’s risk in lieu of a genetic blood-based biomarker, like PRS. However, the accuracy of self-reported family history remains limited as a consequence of incomplete or unreliable information collected during a clinical interview. Existing risk factors for developing psychiatric disorders such as FHx tend to be non-specific in their prediction of outcome. Few research studies have evaluated the possibility of using PRS as a complement to FHx across psychosis spectrum disorders. The present study seeks to examine the relationship between the current standard indirect measure of inherited susceptibility being used, FHx, and an individual’s PRS to more directly predict risk of familial susceptibility in those diagnosed with schizophrenia (SZ) by comparing SZ probands based on their FHx of psychotic disorders diagnosis. METHODS: 396 SZ Probands with FHx data were identified. Data on polygenic risk scores for SZ (PRSSCZ) and FHx were obtained from the Bipolar-Schizophrenia Network on Intermediate Phenotypes consortium (B-SNIP 1). Genetic susceptibility was identified using PRSSCZ. FHx was established from detailed family interviews. SZ probands with only an affected first-degree relative (n= 42) or only an affected second-degree relative (n= 55) with history of a psychotic disorder diagnosis were included in the analyses. SZ probands without any affected relative (n=179) were used as a comparison group. Demographic information for all participant groups were compared using Chi-square for categorical variables, and ANOVA for continuous variables. ANCOVA was used to identify differences among relative proximity and PRSSCZ while accounting for covariates (age, sex, race). Multiple comparisons were adjusted for using Bonferroni correction. Healthy controls were added as a reference only. The significance level was set at p < 0.05. RESULTS: In SZ probands, there was a significant difference between those with an affected first-degree relative with non-affective psychosis and those without any affected relatives (p< 0.05). No significant difference was observed between those with an affected second-degree relative with non-affective psychosis and those without any affected relatives. Having only an affected first-degree relative with non-affective psychosis carries significantly more risk than having only an affected second-degree relative with non-affective psychosis (p< 0.05). CONCLUSIONS: These findings a) support the validity of taking careful family history of non-affective psychosis diagnosis when evaluating individuals with a psychotic disorder, b) suggest that PRSSCZ may be a useful complement to taking family history, and c) relative proximity is important in risk for SZ. The limitations of this study include lack of direct interviews of affected first- and second-degree relatives, and the lack of complete pedigree information that might allow for calculation of familial load.

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No description available.

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No description available.

No description available.