The purpose of the present study was to objectively verify psychological and behavioral changes in a group of identifiably susceptible patients who were treated for environmental sensitivities in a highly controlled environment. The subjects were 71 Environmental Control Unit (ECU) patient volunteers and 16 nonpatient volunteers for a total of 87. The patients were divided into a short-treatment (fasting 3-4 days) group (n = 35) and a long-treatment (fasting 5-7 days) group (n = 36). A third group, consisting of the 16 nonpatients, formed a nonpatient/no-treatment control group. All subjects were administered tests for assessment of intellectual/cognitive functioning, neurological/cerebral functioning, perceptual-motor skills, mood states, and general psychopathology.

Weight loss maintenance and emotional and physical problems were investigated in subjects on a protein-sparing modified fast. Four months following a weight reduction program using the protein-sparing modified fast, twenty of the forty-two subjects were contacted. Each was asked to complete a questionnaire related to emotional and physical effects of the diet and a diet history checksheet. Each subject was weighed to determine if weight loss had been maintained. Results of the questionnaire, diet history, and blood chemistry analysis indicate that for these subjects, the modified fast may be safe and effective in reducing and maintaining weight loss over a short time period under close supervision by a physician.