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The presence of pollutants known as emerging contaminants in water and wastewater is a topic of growing interest. Emerging contaminants, which include endocrine disrupting chemicals (EDCs) and pharmaceutical and personal care products (PPCPs), are compounds that remain relatively unknown, although their adverse effects have been proven. Emerging contaminants are not satisfactorily removed by traditional treatment methods; therefore, there is a need for innovative techniques. Advanced oxidation processes (AOPs) have been recognized as successful removal methods for these problematic pollutants. However, technical success is not the only factor that must be considered. Process engineering, environmental, and economic and social parameters were considered. A holistic analysis was completed using a ranking system to determine the performance of several AOPs (ozonation, UV, photocatalysis, the Fenton reaction, and integrated processes). Ultimately, H2O2/O3 presented the highest average ranking (3.45), with the other processes showing similar performance, with the exception of TiO2 photocatalysis (2.11).

Removal of sediment by dredging causes excessive erosion and ecosystem disruption. The objective of this study is to consider recycled glass as a feasible, economical, and environmentally friendly alternative material for coastal replenishment. Recycled glass cullet possesses the same physical and chemical properties as natural quartz sand found on beaches. A field study conducted in Mississippi showed little variation across three depths. Analysis determined the sediment size ratio (or distribution) of beach sand and glass cullet. Results show the most common grain size of sand in Mississippi is 0.25 mm and the grain size of cullet is comparable. Analytical Spectral Data (ASD) assessed the compositional variation between the sediment and glass cullet. Comparative cost estimate shows glass cullet is indeed a feasible alternative aggregate to dredged sediment for beach replenishment and has the potential to protect shelf ecosystems from unnecessary dredging and create use for recycled glass. Keywords: glass, cullet, recycling, beaches, renourishment, analytical spectral device, feasibility

The main objective of this study is to develop a methodology which can be used to assess the economic potential for combined heat and power (CHP) systems to be employed in an effort to offset a portion or all of the conventionally supplied power and thermal energy at industrial manufacturing facilities. A methodology is developed which determines the economic considerations of proposed industrial CHP projects once the system configuration is specified. This methodology is then applied to a number of different industrial facilities in a parametric analysis in order to demonstrate how it can be used to assess the potential for success for CHP at industrial sites for a wide range of manufacturing processes. Many of the methodology inputs, such as facility operational hours, facility thermal load, etc. are then varied in order to determine how they affect the economic considerations of the corresponding project. Conclusions are subsequently made as to how each of these parameters can be indicative of project success before employing the methodology. This study focuses on industrial sites in the Southeast U.S., which historically have relatively low utility usage rates. The Southeast U.S. also lacks adequate policy applicable to CHP systems, such as net metering and interconnection standards rules, when compared to the rest of the country. It is for this reason that the methodology developed in this research assumes that a base load CHP system is the most economically viable CHP option and the current status of policy applicable to CHP at industrial facilities located in the Southeast U.S. is also investigated. The results of the parametric analysis are modified to determine if improved economics can be attained if the associated facilities engage in net metering programs. As a result, suggested net metering rates that can positively affect the economic considerations of industrial CHP projects in the Southeast U.S. are realized. Finally, a simple tool based on the methodology presented in this research was developed and can be used to calculate the project economics of an industrial facility CHP system.

Pilot studies, a subset of feasibility studies, are essential in determining the feasibility of a larger study. This is especially true when targeting populations that are difficult to recruit, such as people with HIV. Designing high quality pilot studies can help limit waste by informing researchers how to proceed. We conducted a meta-epidemiological review of pilot studies in the HIV literature published until November 25, 2020 using Medline, Embase and Cochrane Controlled Register of Trials (CENTRAL). We extracted bibliometric information, including the region and income of the country where the study was conducted, study design, using the pilot label, source of funding, nature of intervention, whether feasibility was the primary objective, progression criteria, protocol registration and sample size estimation. We used descriptive analysis to evaluate how pilot studies are designed and conducted, the outcomes assessed and how are they defined. Our search retrieved 10,597 studies, of which 248 were included in our final review. The number of pilot studies has increased with time, with 25, 55, and 44 HIV studies published in 2018, 2019, and 2020, respectively. We found that 128 studies (70.39%) used the pilot or feasibility labels in their title, however 20.31% used these titles interchangeably. 5 studies in this review included progression criteria, all of which were published in 2020. Sample size estimation was only found in 59 studies (23.9%). Pilot studies in the HIV literature are mislabeled. Sample size estimations are seldom included, and progression criteria are used. Formal guidance on the design and reporting of pilot studies in the HIV literature is necessary. / Thesis / Master of Science (MSc) / Pilot studies are important in evaluating whether planned larger studies can be conducted. They are particularly useful in the field of HIV where participants may be hard to identify and recruit. However, there are few instructions on how pilot studies in HIV should be designed. We searched the literature to see the current state of HIV pilot studies, including how they are designed, and their findings reported. We found that pilot studies are becoming more popular in the HIV field. However, there were gaps in how these studies are designed and reported. Studies were often mislabeled as pilots when they were not, the pilot study criteria were applied inconsistently and the outcomes that were evaluated were often poorly defined and their information poorly presented. Pilot studies in HIV can be reported better.

Objective: The purpose of this study was to assess the feasibility of conducting a prospective cohort study during early pregnancy (<24 weeks gestation) examining the psychological factors associated with excessive pregnancy weight gain. Study Design: Women who had at least 1 prenatal care visit, had a live singleton gestation and were able to read English were eligible to enroll in the study. Women completed the self-administered survey at their prenatal clinics in Hamilton and Brantford, Ontario, Canada. Final pregnancy weight was obtained from women’s clinical charts. Results: All approached clinics agreed to participate in the study (100% clinic agreement). Five hundred thirty women completed the enrolment survey, which was a 90.0% uptake rate. An average of 6 women enrolled each week at less than 24 weeks gestation. Less than 10% of data were missing for all survey questions and outcome data (final pregnancy weight) was available for all but one participant (97.3%). Final pregnancy weights were obtained a median of 1.0 days (interquartile 0.0-3.5 days) prior to delivery. No psychological factors were significantly associated with the odds of gaining above the 2009 IOM/Health Canada guidelines in the exploratory univariate analysis. Conclusion: All feasibility outcomes demonstrated that conducting a full-scale study in Southwestern Ontario would be feasible. Conducting a full-scale study may identify associations between psychological factors and excessive pregnancy weight gain. / Thesis / Master of Science (MSc)

Selenium (Se), an essential trace element, plays an important role in the normal function of a number of Se-dependent biological processes. Many studies have demonstrated that selenium deficiency in the body may contribute to an increased risk for certain neoplastic diseases (including colonic carcinoma, gastric carcinoma, pulmonary carcinoma and prostate carcinoma), as well as diseases of the cardiovascular, osseous, nervous systems and retardation of bone formation. However, at higher concentrations Se is cytotoxic. For these reasons it is desirable to have a means of monitoring selenium concentration in humans. The feasibility of measuring selenium in humans using the in vivo neutron activation analysis (IVNAA) technique was studied. For this purpose human hand tissue equivalent phantoms were prepared with varying amounts of selenium and irradiated by a low energy neutron beam produced by the 7Li(p,n)7Be reaction by employing the high beam current Tandetron accelerator. The counting data saved using the 4π NaI(TI) detection system in anticoincidence, coincidence and singles modes of detection were analyzed. The selenium was detected via the neutron capture reaction, 76Se(n,γ)77mSe, whereas calcium was detected through the 48Ca(n,γ)49Ca reaction. The peak areas of Se and Ca were computed and the Se concentrations were normalized to the Ca concentrations for various time segments of detection. The calibration lines were drawn between Se/Ca concentration and Se/Ca counts ratio. The minimum detection limits (MDL) were obtained and the inverse variance weighted mean value of MDL was finally calculated for three time segments. During the analysis of counting data it was also found that 18O is activated in water phantoms and becomes short lived radioactive 19O having T1/2=26.9 s. To the author’s best knowledge, this study for the first time presents the MDL value in terms of Se/Ca concentration for the human hand bone equivalent phantom obtained from in vivo neutron activation analysis and these results will provide a good basis for future investigations. / Thesis / Master of Science (MSc)

<p> This thesis explored the feasibility of using a decision-making approach to explain changing agricultural land-use patterns in the rural-urban fringe. The change in farm ownership to a non-farmer user was assumed to reflect a change in land use. A basic objective was to identify and describe the types of elements which composed the farmers mode of perception of the decision-making context. Variations in the modes of perception were then related to an array of socio-economic characteristics of the landowner. </p> <p> The investigation confirmed the utility of the decision-making approach and confirmed the importance of the land appreciation component to the decision context. The selling price which the farmer appraised his property at was critical in determining whether the property was sold. Empirical analysis suggested a significant relationship between the selling price and the economic viability of the farm operation.</p> / Thesis / Master of Arts (MA)

One of two project reports. The other is designated PART A: McMASTER (ON-CAMPUS) PROJECT / <p> It is well known that heart rate is an important physiological parameter. In some cases, continuous monitoring of active subjects is desireable. </p> <p> The report focuses on the feasibility of a miniaturized, portable heart rate monitor. Good artifact rejections, low power consumption small size and ease of use are of primary importance in such design. In order to keep size as low as possible a single cell (1 .5 V) supply voltage is used. </p> <p> A LED - phototransistor type of transducer was chosen for its good artifact rejection and simplicity of application. The transducer clips on the subject's earlobe. Light transmitted through the earlobe is amplitude modulated by the heart (blood) pulses and detected by the phototransistor thus providing electrical signal. </p> <p> In order to keep current drain low, the LED was powered by ~ 1% duty cycle pulses. The rest of the system was designed to comply with the requirements of the transducer. The detected train of pulses were preamplified and the original modulating waveform (heart pulse) reconstructed by a "sample and hold" circuit. The reconstructed signal was amplified by a narrow-band-pass amplifier filter. </p> <p> An astable and two monostable multivibrators perform the necessary timing. Two integrated circuits were also employed: a voltage regulator, to provide stable reference voltages where needed and the output amplifier filter, providing the bulk of the gain. </p> <p> A working prototype was built and suggests that a personalized heart rate monitor is quite feasible. The whole circuit can be integrated, with the exception of few capacitors and perhaps some trimming potentiometers. </p> / Thesis / Master of Engineering (MEngr)

PhD Thesis / Older adults are a rapidly growing segment of the population with unique healthcare needs. As people age, they are more likely to become susceptible to diseases and develop complex health conditions that require tailored strategies to address. These vulnerabilities could also impact different stages of the research process to generate evidence that promote healthy aging and better quality of life for this population. Attrition and missing data are some of the common methodological challenges in research with older adults. These issues could affect the quality of evidence generated if not properly addressed. There is also limited evidence to guide the development of interventions in specific populations of older adults with frailty, who have reduced function and are at higher risk for poor health outcomes. Across six chapters, this thesis addresses these methodological and interventional gaps in research with older adults. Using different research methodologies including a systematic literature survey, secondary data analysis of a cohort study, and two randomized feasibility trials, this thesis provides some important considerations for practice. In particular, we (i) evaluated the magnitude, pattern, and factors associated with attrition in the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort of older adults; (ii) performed a systematic survey of the reporting and handling of missing data in longitudinal observational studies of older adults; (iii) conducted a randomized controlled feasibility trial of the Geras virtual frailty rehabilitation program to build resilience in vulnerable older adults during the COVID-19 pandemic; and (iv) evaluated the feasibility of the FitJoints randomized controlled trial of a multimodal intervention in frail older patients with osteoarthritis awaiting hip and knee replacement. / Thesis / Doctor of Philosophy (PhD) / The number of people who are old is increasing by the day and so is the need to understand how to ensure they are aging well. Old age makes people more prone to diseases. The risks of becoming ill could make the efforts to generate knowledge that can help them thrive challenging. They could drop out of a study making it difficult to collect enough information for data analysis. For some older adults who are frail and have higher risk for diseases, there is little known about how to design programs that will enable them stay active and healthier during the COVID-19 pandemic or before they have hip or knee replacement surgery. This thesis contributes to the knowledge on how to improve the quality of research involving older adults and bridge the gap in the knowledge about how to support those who are frail among them.