Over the past years, microfluidic systems have been rapidly developed from early single channel devices to current complex integrated analysis systems. The development in microfluidics has led to the realization of miniaturized applications in biomedical or chemical analysis. High throughput and automated microfluidic systems have made it possible to achieve biomedical or chemical instruments with new levels of performance and capability. However, because of the requirement of biomedical systems, disposed and optically transparent materials, high aspect ratio structures, and complicated fluidic connection are desirable. Conventional silicon microfabrication process may not overcome these limitations. In this work, micro molding replication technique is proposed as a low-cost polymer microfabrication technique. Based on this technique, four polymer based microfluidic devices, which are vortex micropump, discretized micromixer, carbon nanotube based flow sensor, and Surface Plasmon Resonance (SPR) imaging biosensor have been designed, fabricated and demonstrated. According to different applications, these individual devices can be integrated into an automated microfluidic analysis system to sense, regenerate, and deliver fluid volumes in the order of micro-liters. This miniaturized and integrated system can provide a high throughput, increased resolution, and better controllable environment. Using the integrated and automated microfluidic system, two biomedical experiments, including monitoring of bovine serum albumin (BSA) binding reaction with BSA antibodies, and cell adhesion properties under the influence of trypsin, have been conducted. / Lei Kin Fong Thomas. / "August 2005." / Adviser: Wen J. Li. / Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 4065. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (p. 88-98). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract in English and Chinese. / School code: 1307.

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