Australia is a culturally diverse country with many migrant and refugee families in need of mental health services. Yet, surveys indicate that many culturally diverse community members do not feel comfortable in accessing mental health services, often due to a limited understanding of current western practices and the lack of practitioner cultural sensitivity. Despite the apparent need, few investigations have been conducted with migrant families to understand their different values and needs, and identify how they adjust to a new culture. The paucity of empirical research is largely due to the number of variables associated with the process of cultural change, and the fact that culture itself may lend different meaning to symptom experience, and the expression thereof. Moreover, because migrant adaptation is a complex and multifaceted phenomenon, it is often rendered difficult to investigate. Cultural groups have been observed to exhibit differences in the pathogenesis and expressions of psychological adjustment, thus making culturally sensitive assessment a particularly arduous yet important task. Although the number of studies conducted on cultural adaptation trends of adult migrants is growing, few investigations have examined the acculturation experiences of children and adolescents. Moreover, the link between acculturation and mental health has confounded researchers and practitioners alike. Considering assessment procedures largely influence therapeutic strategies, it is deemed essential that Australian health care professionals understand language, behavioural, and motivational differences between ethnic groups. In response to appeals for empirical data on culture-specific differences and developmental pathways of emotional resiliency and psychopathology, the present research program examines the complex interplay between situational factors and internal processes that contribute to mental health among young migrants and refugees. The research focuses particularly on anxiety, which is not only the most common form of childhood psychopathology but also frequently coincides with stressful life events such as cultural relocation. Two hundred and seventy-three primary and high school students (comprised of former-Yugoslavian and Chinese cultural groups) participated in this research program. Primary (n=131) and high school (n=142) students completed self-report measures of acculturation, internalising symptoms, social support, self-concept/esteem, ethnic identity, and future outlook, and were compared by cultural group, heterogenic ethnicity, school level, gender, and residential duration variables. Specifically, Study 1 aimed to map the cultural adjustment patterns of migrant youth so as to determine both situational and internal process risk and protective factors of emotional distress. The main findings from Study 1 indicate: (1) patterns of cultural adjustment differ for children and adolescents according to cultural background, gender, age, and length of stay in the host culture; (2) former-Yugoslavian migrants generally report greater identification and involvement with Australian cultural norms than Chinese migrant youth; and (3) the divergent variables social support and bicultural adjustment are not universally paired with acculturative stress, as previously indicated in other adult migrant and acculturation studies. These outcomes highlight the importance of addressing the emotional and psychological needs of young migrants from unique age-relevant cultural perspectives. Building on these outcomes, the aim of Study 2 was to propose an organisational structure for a number of single risk factors that have been linked to acculturative stress in young migrants. In recognising that divergent situational characteristics (e.g., school level, gender, residential duration in Australia, social support, and cultural predisposition) are selectively paired with internal processing characteristics (e.g., emotional stability, self-worth/acceptance, acculturation/identity, and future outlook), a top-down path model of acculturative stress for children and adolescents of Chinese and former-Yugoslavian backgrounds was proposed and tested. To determine goodness of model fit, path analysis was employed. Specific cross-cultural profiles, application for the proposed age and culture sensitive models, and research considerations are discussed.