Yes / This paper presents the development of a Knowledge-Based System (KBS) to support the implementation of Lean Six Sigma (L6σ) principles applied to enhance Quality Management (QM) performance within a Healthcare Environment. The process of KBS building has been started by acquiring knowledge from experts in field of L6σ and QM in healthcare. The acquired knowledge has been represented in a rule-based approach for capturing L6σ practices. These rules are produced in IF….THEN way where IF is the premise and THEN is the action. The produced rules have been integrated with Gauging Absence of Pre-requisites (GAP) technique to facilitate benchmarking of best practice in a healthcare environment. A comprehensive review of the structure of the system is given, detailing a typical output of the KBS. Implementation of L6σ principles to enhance QM performance in a Healthcare Environment requires a pre-assessment of the organisation’s competences. The KBS provides an enhanced strategic and operational decision making hierarchy for achieving a performance benchmark. This research presents a novel application of a hybrid KBS with GAP methodology to support the implementation of L6σ principles to enhance QM performance in a healthcare environment.