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Le but de cette thèse est d’étudier profondément le repliement des protéines, au moyendes concepts d’invariance de jauge et d’universalité. La structure de jauge émerge del’équation de Frenet qui est utilisée pour décrire la forme de la chaîne principale de laprotéine. Le principe d’invariance de jauge conduit à une fonctionnelle d’énergieeffective pour une protéine, développée dans le but d’extraire les propriétésuniverselles des protéines repliées durant la phase d’effondrement, et qui estcaractérisée par la loi d’échelle du rayon de giration au niveau tertiaire de la structureprotéique. Dans cette thèse, on étudie l’existence d’une large universalité au niveausecondaire de la structure protéique. La fonctionnelle d’énergie invariante de jaugealliée à l’équation de Frenet discrète conduit à une solution solitonique, identifiéecomme un motif hélice-boucle-hélice dans la protéine. / The purpose of this thesis is to investigate protein folding, by means of the general concepts of gauge invariance and universality. The gauge structure emerges in the Frenet equation which is utilized to describe the shape of protein backbone. The gauge invariance principle leads us an effective energy functional for a protein, which bas been found to catch the universal properties of folded proteins in their collapse phase,characterized by the scaling law of gyration radius on the tertiary level of proteinstructure. In this thesis, the existence of wide universality on the secondary level of protein structure is investigated. The synthesis of the gauge-invariant energy functional with the discrete Frenet equation leads to a soliton solution, which is identified as the helix-loop-helix motif in protein.

In this thesis we focus on Grand Unified Theories based on the SO(10) gauge group and, in particular, on the viability of the minimal nonsupersymmetric SO(10) models. Technically, this amounts to a detailed assessment of their vac- uum stability and related (non-)tachyonicity of their scalar spectrum. It turns out that the one-loop scalar mass corrections are important for elimination of the tachyonic behaviour of certain pseudo-Goldstone bosons. In this work these issues are briefly reviewed and two distinct methods for the calculation of the critical radiative corrections are discussed. More specifically, besides the revision of the effective potential approach to the 45 ⊕ 16 Higgs model also the standard perturbative theory method is employed for this purpose. The latter approach is particularly suitable for the more realistic 45 ⊕ 126 Higgs model since it appears to be practically impossible to construct the corresponding effective potential in that case. Consequently, diagrammatic methods are used to calculate the SO(10)- invariant leading scalar quantum correction to the problematic pseudo-Goldstone masses in the 45 ⊕ 126 model. 1

La notion de symétrie de jauge est au coeur de notre compréhension de l'interaction électrofaible et permet d'expliquer l'ensemble des observations expérimentales actuelles. Pourtant, l'incompatibilité intrinsèque entre l'invariance de jauge et la masse des particules nécessite d'introduire une nouvelle particule, le boson de Higgs, toujours non observée à ce jour. Cette thèse présente l'analyse de 7.3/fb de collisions protons-antiprotons à sqrt{s} = 1.96 TeV enregistrées par le détecteur D0 au Tevatron en vue de la recherche du boson de Higgs dans l'état final mu+tau. Cette analyse vient compléter les canaux principaux dimuons, électron-muon et diélectrons en exploitant également la désintégration H -> WW -> lvlv, majoritaire dans la fenêtre de masse accessible au Tevatron. L'état final contenant un lepton tau, leur identification parmi les jets a été améliorée d'environ 15% grâce au développement de plusieurs idées : l'ajustement des paramètres du réseau de neurones d'identification, la prise en compte de certaines dépendances cinématiques des performances de l'algorithme, l'exploitation du temps de vie du lepton tau et une étude exhaustive visant à inclure la mesure du détecteur de pieds de gerbe dans le processus d'identification. Dans un second temps, la recherche du boson de Higgs dans l'état final mu+tau étant dominée par le bruit de fond W+jets (où un jet est faussement identifié comme un lepton tau), une méthode a été élaborée pour obtenir une modélisation convenable de ce bruit de fond, non fournie par la simulation par défaut. Cette méthode est basée, entre autres, sur l'étude de la corrélation de charge entre le muon et le candidat tau qui permet de mesurer ce bruit de fond dans les données en excluant la région du signal. Ensuite, l'exploitation des cinématiques et/ou topologies différentes du signal et du bruit de fond a permis d'optimiser cette recherche atteignant alors une sensibilité attendue (observée) de 7.8 (6.6) fois le Modèle Standard pour une masse de 165 GeV/c2. Enfin, l'interprétation de l'analyse dans un scénario à quatre familles de fermions a été effectuée. Pour la première fois, cette analyse est incluse dans les combinaisons D0 et Tevatron présentées à Moriond EW et EPS 2011. / The gauge symmetry is the heart of our understanding of the electroweak interaction and describes all the current experimental results. However, the intrinsic incompatibility between the gauge invariance and the mass of particles leads to the introduction of a new particle, the Higgs boson, for which we have no experimental evidence as of today. This thesis describes the Higgs boson search in the mu+tau final state in 7.3/fb of protons-antiprotons collisions at sqrt{s} = 1.96 TeV collected by the D0 detector at the Tevatron. This analysis completes the golden channels (dimuons, electron-muon, dielectrons) exploiting the decay chain H-> WW ->lvlv, which is the main Higgs boson decay mode in the mass window accessible to the Tevatron. Since the final state includes a tau lepton, work was done to improve their identification among jets. An increase of 15% was achieved thanks to the the following : changing tuning parameters for the tau identification neural network, use of the kinematical dependence of the algorithm performances, incorporation of the tau lepton life time information and full study of the additionnal information coming from the central preshower measurements. Then, since the dominant background of the mu+tau Higgs boson search is W+jets (where one jet fakes a tau), a method was developed to obtain good modeling of this background, not provided by the default simulation. This method is based, among other things, on the charge correlation between the muon and the tau candidate which allows for calibration of this background in the data excluding the signal region. Finally, all the kinematic and/or topological differences between the signal and the background were exploited to optimize this search, reaching an (observed) expected sensitivity of 7.8 (6.6) times the Standard Model for mH = 165 GeV/c2. In addition, this result was also interpreted in a fourth fermion generation scenario. For the first time, this analysis is included in the D0 and Tevatron combinations, both presented at Moriond EW and EPS 2011.

The thesis treats aspects of string/M-theory in anti-de Sitter spacetimes and their supersymmetric completions. By applying the AdS/CFT correspondence, as well as models of spin chains and singletons, we try to attain a better understanding of the underlying symmetries and the unbroken phases of string/M-theory. Tensionless string/M-theory in anti-de Sitter spacetime is argued to imply a higher spin gauge symmetry enhancement and to be described by gauged sigma models of multi-singletons as well as by closed singleton strings. Vasiliev's weakly projected equations of symmetric massless higher spin gauge fields in the vector oscillator formulation is shown to follow from a deformation of the singleton model. Various four dimensional minimal as well as non-minimal supersymmetric higher spin gauge theories in the spinor formulation are examined. The minimal higher spin gauge theory based on the symmetry algebra hs(1|4) is elaborated on in an N=1 superspace, illustrating the remarkable fact that the choice of base manifold is not fixed in unfolded dynamics. The importance of the representations saturating the unitarity bounds in anti-de Sitter spacetime is stressed throughout the thesis, with particular emphasis on the singleton and the massless representations. Singletons, and hence massless states, are shown to appear as bound states on the string or p-brane and are localized at cusps. Furthermore, we examine semiclassical string solutions in Type IIB String Theory in AdS(5) x S(5) and their boundary duals in N=4 Super Yang-Mills Theory in d=4 which are constituted out of thermodynamic composite operators. By using integrable spin chain techniques and Bäcklund transformations in the field theory and in the string theory, respectively, the one-loop anomalous dimensions as well as the tower of conserved charges of the composite operators are shown to be in agreement with the energies and the tower of conserved charges associated with the dual string states.