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Polyoxometalates (POMs) are a class of transition-metal oxide clusters with significant applications in material science as well as in the biomedical field. Recently, it has been reported that POMs exhibit antitumor activity. POMs containing molybdenum (Mo), tungsten (W), and vanadium (V) with oxygen are three types of POMs with different structural features introduced by our lab as a novel inorganic chemotherapeutic agent for cancer treatment. In this study, Vanadium polyoxometalate (V-POM), which exhibited highest cytotoxicity in 5 different cancer cell lines in in vitro experiment, will be incorporated with Gelatin type B through polymer modification in hopes of prolonging circulation time and avoiding undesired toxicity. The stability, cellular uptake, and cytotoxicity of the V6-POM/Gelatin nanoparticles will be investigated in vitro. The reported study indicates the feasibility of using V6-POM/gelatin nanoparicles for anticancer applications.

Thesis (M.S.)--University of Missouri, School of Mines and Metallurgy, 1921. / Vita. The entire thesis text is included in file. Typescript. Illustrated by author. Title from title screen of thesis/dissertation PDF file (viewed May 29, 2009) Includes bibliographical references (p. 24).

Abstract of Thesis (Ph. D.)--University of Illinois, 1930. / Vita. eContent provider-neutral record in process. Description based on print version record. "Bibliography": p. [6].

Inaug.-diss.--Heidelberg. / Lebenslauf.

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2007. / Includes bibliographical references (leaves 110-116). Also available in electronic version.

外科手術後の癒着防止を目的としてゼラチンを使用した新規癒着防止材を開発した。ゼラチンを数種類の形状に加工し、その有用性を従来製材との比較のもとに検討した。実験により①熱架橋を行うことで性質を制御でき、様々な形状にも容易に加工できる。②創傷治癒を阻害することなく十分な癒着防止効果を持ち、従来製材では禁忌とされていた環境でも使用が可能である。③腹腔鏡手術でも使用可能な材型にも加工できるとの結果を得た。 / To prevent adhesion after surgical operation, we developed a new anti-adhesive material that is made of gelatin. We processed gelatin into several kinds of shapes and examined its usefulness compared with conventional materials. We got the result that ① it can be controlled properties by thermal crosslinking, and easily processed into various shapes ② It has sufficient anti-adhesive effects without inhibiting wound healing, and can be used the sites which are typically contraindicated for conventional materials. ③ it can be processed into a shapes that can be used also in laparoscopic surgery. / 博士(理学) / Doctor of Philosophy in Science / 同志社大学 / Doshisha University

Thesis (Ed.D.)--Teachers College, Columbia University, 1991. / Typescript; issued also on microfilm. Sponsor: Joan Dye Gussow. Dissertation Committee: Isobel Contento. Includes bibliographical references (leaves 198-203).