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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 2 of 2 (0.057 seconds)Spelling suggestions: "subject:"ghrelin receptor"" "subject:"ghrelina receptor""
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Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular ImagingMoldovan, Rares-Petru, Els-Heindl, Sylvia, Worm, Dennis J., Kniess, Torsten, Kluge, Michael, Beck-Sickinger, Annette G., Deuther-Conrad, Winnie, Krügel, Ute, Brust, Peter 03 January 2024 (has links)
The ghrelin receptor (GhrR) is a widely investigated target in several diseases.
However, the current knowledge of its role and distribution in the brain is limited. Recently,
the small and non-peptidic compound (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one ((S)-9) has been described as a GhrR ligand
with high binding affinity. Here, we describe the synthesis of fluorinated derivatives, the in vitro
evaluation of their potency as partial agonists and selectivity at GhrRs, and their physicochemical
properties. These results identified compounds (S)-9, (R)-9, and (S)-16 as suitable parent molecules
for 18F-labeled positron emission tomography (PET) radiotracers to enable future investigation of
GhrR in the brain.
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Les effets cardioprotecteurs de peptides dérivés des sécrétagogues de l’hormone de croissance dans le modèle d’ischémie-reperfusion du myocarde murinHuynh, David N. 08 1900 (has links)
No description available.
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