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Characterization of nucleoside transport in the intestinal protozoan parasite Giardia intestinalisDavey, Robert Andrew. January 1994 (has links) (PDF)
Includes copies of other papers co-authored by the author at end of thesis. Includes bibliographical references (leaves 241-265) A rapid sampling technique has been adapted and used to measure nucleoside transport in a human-derived isolate of the intestinal protozoan parasite Giardia intestinalis (syn. G. lamblia)
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Characterization of nucleoside transport in the intestinal protozoan parasite Giardia intestinalis /Davey, Robert Andrew. January 1994 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Department of Microbiology and Immunology, 1994. / Includes copies of other papers co-authored by the author at end of thesis. Includes bibliographical references (leaves 241-265).
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Détection et génotypage des kystes de Giardia lamblia à partir de matrices environnementales et d'échantillons biologiquesBertrand, Isabelle Schwartzbrod, Janine January 2005 (has links) (PDF)
Thèse de doctorat : Biologie Santé Environnement. Chimie et microbiologie de l'eau : Nancy 1 : 2005. / Titre provenant de l'écran-titre.
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Production of a cDNA library and studies on gene sequences encoding antigens from the flagellite Giardia intestinalis (Lamblia)Baker, David Andrew January 1988 (has links)
No description available.
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Molecular responses of Giardia lamblia to gamma-irradiationLenaghan, Scott. Sundermann, Christine A., January 2008 (has links) (PDF)
Thesis (Ph. D.)--Auburn University, 2008. / Abstract. Includes bibliographical references.
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The intestinal immune response to Giardia in the rat /Waight Sharma, Agnes Phyllis. January 1988 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1989. / Includes bibliographical references (leaves 183-228).
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Waterborne diseases linking public health and watershed data /Das, Debalina, January 2009 (has links)
Thesis (M.S.)--University of Massachusetts Amherst, 2009. / Includes bibliographical references (p. 81-93).
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Molecular systematics of the protozoan parasite Giardia intestinalis : identification of cryptic species / Paul T. Monis.Monis, Paul T. January 1997 (has links)
Copies of author's previously published articles inserted. / Includes bibliographies. / iii, 277, [81] leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The aim of this research is to investigate the phylogeny of isolates of the intestinal protozoan parasite Giardia intestinalis using molecular systematic techniques. Most of the isolates used in this study are propagated by the infection of suckling mice. Isolates are characterised allozymically and their genetic relationships are inferred using clustering methods. Seven lineages of isolates are identified, five comprising animal-derived G. intestinalis, and two comprising human-and animal-derived G. intestinalis. / Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1997?
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Giardia lamblia genomic and molecular analyses of flippase /Villazana-Kretzer, Diana L. January 2008 (has links)
Thesis (M.S.)--University of Texas at El Paso, 2008. / Title from title screen. Vita. CD-ROM. Includes bibliographical references. Also available online.
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Efeitos do dietilditiocarbamato em trofozoítos de giardia lamblia: uma nova ferramenta na terapia contra a giardíase / Efeitos do dietilditiocarbamato em trofozoítos de giardia lamblia: uma nova ferramenta na terapia contra a giardíaseAnjos, Karla Graziela Santana dos January 2008 (has links)
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Previous issue date: 2008 / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / O protozoário microaerófilo Giardia lamblia coloniza o trato intestinal de hospedeiros
vertebrados, onde é exposto a diferentes concentrações de oxigênio. Apesar do metabolismo
fermentativo, trofozoítos de Giardia consomem oxigênio e mecanismos de detoxificação são
requeridos. Desprovido de glutationa, Giardia expressa altas concentrações de proteínas ricas em
cisteína (CRP, também conhecidas como proteínas variantes de superfície ou VSP), como defesa
antioxidante. Este mecanismo envolve ciclagem redox para a manutenção de um ambiente
intracelular reduzido e proteção contra o estresse oxidativo. Neste contexto, substâncias que
interfiram na resposta antioxidante deste protozoário podem compreender uma poderosa
estratégia quimioterápica contra a giardíase. Neste estudo, nós analisamos os efeitos do
dietilditiocarbamato (DETC), um inibidor de superóxido dismutase (SOD), na proliferação do
parasito, expressão de tióis totais, lipoperoxidação, produção de radicais livres e arquitetura
celular. DETC inibiu a proliferação celular em níveis semelhantes ao metronidazol e induziu a
peroxidação de membranas neste parasito, possivelmente pelo aumento de espécies reativas.
Alterações ultraestruturais também foram observadas neste protozoário. Células tratadas com
DETC apresentaram alto grau de extração citoplasmática, além de estruturas indicativas de
autofagia. As vesículas periféricas também se encontravam maiores, sugerindo confluência. Estes
efeitos são independentes de SOD, já que Giardia não apresenta esta enzima. Detecção de grupos
tiol com a sonda fluorescente o-phthaldialdeído (OPA) foram significantemente moduladas
negativamente pelo DETC. Estes dados nos indicam que DETC aumenta o estresse oxidativo em
trofozoítos de Gardia lamblia pela reação com grupos tiol. / The microaerophilic protozoan Giardia lamblia inhabits the upper small intestine mucosa of
vertebrate hosts, where it is exposed to different concentrations of oxygen. Despite the
fermentative metabolism, Giardia trophozoites consume O2 and produce oxygen free radicals and
therefore mechanism for detoxification are required. Devoid of glutathione, Giardia express high
concentrations of cystein-rich proteins (CRP, also known as variable surface protein or VSP), as
an antioxidant defense. This mechanism involves redox cycling for maintenance of a reduced
intracellular environment and protection from oxidative stress. In this regard, substances that
interfere in the antioxidant response of this protozoan could comprise a powerful
chemotherapeutic strategy for Giardia lamblia infection. Here, we analyzed the effects of DETC,
a superoxide dismutase (SOD) inhibitor, on parasite proliferation, thiol expression, lipid
peroxidation, free radicals detection and cell architecture. DETC inhibited parasite proliferation
at levels similar to metronidazole and induced peroxidation of membrane, possibly by the
increase of reactive species.Ultrastructural alteration were also observed. Since this protozoan is
devoid of SOD, here present data indicate SOD-independ DETC effects. Thiol groups detection
with the fluorescent probe o-phthaldialdehyde (OPA). Cells treated with DETC displayed washed
out cytoplasm and structures indicative of autophagy. The peripheral vesicles also had an
increased volume, presumably caused by homophilic fusion. Taken together these data indicate
that DETC enhance the oxidative stress in Giardia trophozoites by reacting with thiol groups.
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