Chan Yung. / Publication date from spine. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 80-95). / Acknowledgement --- p.3 / Abstract --- p.4 / Chapter Chapter 1 --- Introduction --- p.7 / Chapter "1,1" --- Current status in treatment of gliomas --- p.7 / Chapter 1.1.1 --- Surgery of gliomas --- p.7 / Chapter 1.1.2 --- Radiation therapy of gliomas --- p.9 / Chapter 1.1.3 --- Chemotherapy for gliomas --- p.10 / Chapter 1.1.4 --- New modalities --- p.11 / Chapter 1.2 --- Basic principle of photodynamic therapy --- p.13 / Chapter 1.2.1 --- Photosensitizer --- p.13 / Chapter 1.2.2 --- Photosensitising effect of HpD --- p.13 / Chapter 1.2.3 --- Mechanism of selectivity in PDT --- p.15 / Chapter 1.2.4 --- Selective localization and the blood brain barrier --- p.16 / Chapter 1.2.5 --- Cytotoxic effect of PDT --- p.18 / Chapter 1.2.6 --- PDT on normal brain --- p.19 / Chapter 1.3 --- Photodynamic therapy in clinical neurosurgery --- p.21 / Chapter 1.4 --- The aims of the study --- p.26 / Chapter Chapter 2 --- Materials and methods --- p.28 / Chapter 2.1 --- Patient population --- p.28 / Chapter 2.2 --- Photosensitizer --- p.28 / Chapter 2.3 --- Administration of HpD --- p.29 / Chapter 2.4 --- Measurement of HpD --- p.30 / Chapter 2.5 --- Fluorescence microscopic examination --- p.32 / Chapter 2.6 --- Confocal laser scanning microscopic examination --- p.33 / Chapter Chapter 3 --- Results --- p.38 / Chapter 3.1 --- HpD measurement --- p.38 / Chapter 3.2 --- Fluorescence microscope examination --- p.40 / Chapter 3.3 --- Confocal laser scanning microscope (CLSM) examination --- p.41 / Chapter Chapter 4 --- Discussion --- p.56 / Chapter 4.1 --- Quantifying HpD level --- p.58 / Chapter 4.2 --- Quantifying HpD in the intravenous administration group --- p.59 / Chapter 4.3 --- Quantifying HpD in the intratumoural injection group --- p.63 / Chapter 4.4 --- Flourescence microscopic study of HpD distribution of malignant gliomas --- p.67 / Chapter 4.5 --- Confocal laser scanning microscopy (CLSM) study of HpD localization of malignant gliomas --- p.72 / Chapter 4.6 --- Conclusion --- p.74 / Chapter Chapter 5 --- Summary --- p.76 / Chapter Chapter 6 --- References --- p.80