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Insulin action and secretion after surgical trauma : an experimental study in the rat /Strömmer, Lisa, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.
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An Insulin-Like Growth Factor-I Receptor Defect Associated with Short Stature and Impaired Carbohydrate Homeostasis in an Italian PedigreeMohn, Angelika, Marcovecchio, Maria Loredana, de Giorgis, Tommaso, Pfaeffle, Roland, Chiarelli, Francesco 27 July 2022 (has links)
Mutations in the insulin-like growth factor-I
(IGF-I) receptor (IGF1R) have been associated with prenatal
and postnatal growth retardation. However, little is known about potential effects of mutations in the IGF1R on carbohydrate
homeostasis. Methods: We investigated clinical, endocrine
and metabolic parameters in four family members
carrying a novel IGF1R mutation (p.Tyr387X): an 18-year-old
male (index case), his sister and two paternal aunts. Results:
All family members showed a variable degree of impairment
in prenatal growth, with birth weight standard deviation
scores (SDS) between –1.65 and –2.37 and birth length SDS
between –1.78 and –3.08. Their postnatal growth was also
impaired, with height SDS between –1.75 and –4.86. The index case presented high IGF-I levels during childhood and
adolescence and delayed bone age. The index case and his
two paternal aunts had impaired glucose tolerance (IGT) associated
with a variable degree of alterations in insulin sensitivity
and secretion. In contrast, the index case’s sister, who
had had IGT during pregnancy, showed normal glucose metabolism
but reduced insulin sensitivity. Conclusion: This is
the first study showing an association between a novel IGF1R
mutation and a variable degree of alterations in prenatal and
postnatal growth and in carbohydrate metabolism.
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Metabolická specifika žen s pozitivní anamnézou gestačního diabetu / Metabolic specifics of women with a positive history of gestational diabetesJarošová, Adéla January 2017 (has links)
Gestational diabetes (GDM) is a disorder of glucose metabolism arising for the first time in pregnancy and spontaneously receding after birth. The issue of GDM is very topical since, according to the latest update of diagnostic criteria, up to 17% of pregnant women is threatened by this disorder. The incidence of GDM correlates with the increasing prevalence of overweight/obesity and metabolic syndrome. It is proved that women who have had gestational diabetes have an enormously increased risk of developing type 2 diabetes mellitus (DM2T). The risk accosiated with a gestational diabetes pregnancy stretches beyond the host, and can affect the fetus both directly (e. g. macrosomia development), and epigenetically (increases susceptibility to obesity, DM2T development or cardiovascular disease). Significant influence on the development of GDM (or DM2T) is a body composition that is directly related to lifestyle (nutritional intake and physical activity) and genetic role i salso involved. Early intervention may help delay the risk of developing DM2T and other metabolic complications. In this diploma thesis we monitored metabolic profiles of glucose and lipids and body composition based on anthropometric examination and questionnaires of nutritional income and physical activity. For the complex...
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