Thesis (M.S.)--University of Wisconsin--Madison, 1965. / eContent provider-neutral record in process. Description based on print version record. Bibliography: l. 50-55.

Thesis (Ph. D.)--University of Wisconsin, 1965. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

Thesis (M.S.)--University of Wisconsin--Madison, 1969. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

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C-linked disaccharides were synthesized from 3,4,6-tri-O-acetyl-D-glucal 1 (1,5- anhydro-3,4,6-tri-O-acetyl-1,2-dideoxy-D-arabino-hex-I-enopyranose), 3,4,6-tri-O- acetyl-D-galactal 2 (1,5-anhydro-3,4,6-tri-O-acetyl-1,2-dideoxy-D-lyxo-hex-1- enopyranose) and 3,4-di-O-acetyl-L-fucal 3 (1,5-anhydro-3,4-di-O-acetyl-1,2,6-tri-deoxy- L-lyxo-hex-1-enopyranose) under Lewis acid catalysis (Scheme 1) and compound 4 was further derivatized at the double bond. Dihydroxylation of the glucose dimer 4 gave high allo-diastereoselectivity. The reactions used in the derivatization of 1 were subsequently applied to 2 and 3. The overall yield of 3 was improved to 70 %. All three glycals (10% solution in toluene) reacted quickly with boron trifluoride to give dimerization products in 40-60% yield. Futile attempts at de-O-acetylation of the 2',3'-unsaturated dimer revealed the necessity of functionalization of the double bond prior to such deprotection.

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Made available in DSpace on 2015-08-20T17:09:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-23. Added 1 bitstream(s) on 2015-08-20T17:26:32Z : No. of bitstreams: 1 000843210.pdf: 473237 bytes, checksum: 6bdb449fdfa3ecafefb424569cad3adf (MD5) / Objetivou-se avaliar os efeitos da utilização de fitogênicos (óleos essenciais e bioflavonoides) ou mono e diglicerídeos associados com ácidos orgânicos nas dietas de leitões, dos 21 aos 63 dias de idade, sobre desempenho, incidência de diarreia, taxa de passagem da digesta, características microbiológicas e morfofisiológicas do trato gastrintestinal (pH, concentração de ácidos graxos de cadeia curta, taxas de mitose e de apoptose das células intestinais e estrutura do intestino delgado). Foram utilizados 160 leitões distribuídos no delineamento em blocos ao acaso, sendo 5 tratamentos, 8 repetições por tratamento e a unidade experimental composta por quatro animais. As dietas foram formuladas para as seguintes fases: I - dos 21 aos 35 dias, II - dos 36 aos 49 dias e III - dos 50 aos 63 dias de idade. Os tratamentos consistiram em um Controle Positivo: dieta com antimicrobiano (40 mg/kg de sulfato de colistina) na fase I; Controle Negativo: dieta isenta de antimicrobiano; AO+OE: Controle Negativo com adição de ácidos orgânicos e óleos essenciais; AO+BioF: Controle Negativo com adição de ácidos orgânicos e bioflavonoides; Gli: Controle Negativo com adição de mono e diglicerídeos de ácido butírico. Dos 21 aos 63 dias de idade, o ganho diário de peso foi maior (P<0,05) nos animais alimentados com a dieta Controle Positivo em comparação àqueles da Controle Negativo. As melhores conversões alimentares (P<0,05) foram observadas nos leitões que consumiram as dietas Controle Positivo, AO+OE e Gli, comparadas à dieta Controle Negativo. As menores (P<0,05) profundidades das criptas foram observadas nos leitões alimentados com as dietas AO+OE e Gli em comparação à Controle Positivo. A contagem de Lactobacillus spp. foi maior (P<0,05) nos animais... / The aim of this study was to evaluate the effects of using phytogenic (essential oils and bioflavonoids) or mono and diglycerides, associated with organic acids in the diets of piglets from 21 to 63 days of age on performance, incidence of diarrhea, digesta passage rate, microbiological characteristics and morphophysiological of gastrointestinal tract (pH, concentration of short-chain fatty acids, mitosis and apoptosis rates of intestinal cells and the small intestine structure). It was used 160 piglets, which was distributed in a randomized block design, with five treatments and eight repetitions per treatment and the experimental unit composed of four animals. The diets were formulated to the following phases: I - from 21 to 35 days, II - 36 to 49 days and III - from 50 to 63 days of age. The treatments consisted of a Positive Control: diet with antimicrobials (40 mg/kg of colistin sulphate) in phase I; Negative Control: diet free of antimicrobial; AO+OE: Negative Control with the addition of organic acids and essential oils; AO+BioF: Negative Control with the addition of organic acids and bioflalanoids; Gli: Negative Control with the addition of mono and diglycerides butyric acid. From 21 to 63 days of age, the daily weight gain was greater (P<0.05) in animals fed with the Control Positive diet in comparison to those of the Negative Control. The best food conversions (P<0.05) were observed in piglets fed with the diets Positive Control, AO+OE and Gli in comparison to the Control Negative diet. The lowest (P<0.05) depths of the crypts were observed in piglets fed with diets AO+OE and Gli compared to those in the Positive Control diet. The count of Lactobacillus spp. was higher (P<0.05) in animals fed with the diets AO+OE in comparison to the Negative Control. It was concluded that the combination ...

Orientador: Maria Cristina Thomaz / Banca: Fabio Enrique Lemos Budiño / Banca: Luciano Hauschild / Resumo: Objetivou-se avaliar os efeitos da utilização de fitogênicos (óleos essenciais e bioflavonoides) ou mono e diglicerídeos associados com ácidos orgânicos nas dietas de leitões, dos 21 aos 63 dias de idade, sobre desempenho, incidência de diarreia, taxa de passagem da digesta, características microbiológicas e morfofisiológicas do trato gastrintestinal (pH, concentração de ácidos graxos de cadeia curta, taxas de mitose e de apoptose das células intestinais e estrutura do intestino delgado). Foram utilizados 160 leitões distribuídos no delineamento em blocos ao acaso, sendo 5 tratamentos, 8 repetições por tratamento e a unidade experimental composta por quatro animais. As dietas foram formuladas para as seguintes fases: I - dos 21 aos 35 dias, II - dos 36 aos 49 dias e III - dos 50 aos 63 dias de idade. Os tratamentos consistiram em um Controle Positivo: dieta com antimicrobiano (40 mg/kg de sulfato de colistina) na fase I; Controle Negativo: dieta isenta de antimicrobiano; AO+OE: Controle Negativo com adição de ácidos orgânicos e óleos essenciais; AO+BioF: Controle Negativo com adição de ácidos orgânicos e bioflavonoides; Gli: Controle Negativo com adição de mono e diglicerídeos de ácido butírico. Dos 21 aos 63 dias de idade, o ganho diário de peso foi maior (P<0,05) nos animais alimentados com a dieta Controle Positivo em comparação àqueles da Controle Negativo. As melhores conversões alimentares (P<0,05) foram observadas nos leitões que consumiram as dietas Controle Positivo, AO+OE e Gli, comparadas à dieta Controle Negativo. As menores (P<0,05) profundidades das criptas foram observadas nos leitões alimentados com as dietas AO+OE e Gli em comparação à Controle Positivo. A contagem de Lactobacillus spp. foi maior (P<0,05) nos animais... / Abstract: The aim of this study was to evaluate the effects of using phytogenic (essential oils and bioflavonoids) or mono and diglycerides, associated with organic acids in the diets of piglets from 21 to 63 days of age on performance, incidence of diarrhea, digesta passage rate, microbiological characteristics and morphophysiological of gastrointestinal tract (pH, concentration of short-chain fatty acids, mitosis and apoptosis rates of intestinal cells and the small intestine structure). It was used 160 piglets, which was distributed in a randomized block design, with five treatments and eight repetitions per treatment and the experimental unit composed of four animals. The diets were formulated to the following phases: I - from 21 to 35 days, II - 36 to 49 days and III - from 50 to 63 days of age. The treatments consisted of a Positive Control: diet with antimicrobials (40 mg/kg of colistin sulphate) in phase I; Negative Control: diet free of antimicrobial; AO+OE: Negative Control with the addition of organic acids and essential oils; AO+BioF: Negative Control with the addition of organic acids and bioflalanoids; Gli: Negative Control with the addition of mono and diglycerides butyric acid. From 21 to 63 days of age, the daily weight gain was greater (P<0.05) in animals fed with the Control Positive diet in comparison to those of the Negative Control. The best food conversions (P<0.05) were observed in piglets fed with the diets Positive Control, AO+OE and Gli in comparison to the Control Negative diet. The lowest (P<0.05) depths of the crypts were observed in piglets fed with diets AO+OE and Gli compared to those in the Positive Control diet. The count of Lactobacillus spp. was higher (P<0.05) in animals fed with the diets AO+OE in comparison to the Negative Control. It was concluded that the combination ... / Mestre