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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.039 seconds)

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1

Development and characterization of pro-apoptotic drug candidates for anticancer drug discovery

Kanyanda, Stonard Sofiel Elisa January 2013 (has links)
Philosophiae Doctor - PhD / Cancer is one of the leading causes of death worldwide. According to the WHO, cancer accounted for 7.4 million deaths world wide in 2004. The metallo-compound cisplatin has been used for years as an effective antitumor agent for treating solid tumours such as breast, bladder, lung, oesophageal, and head and neck carcinomas. However, the use of cisplatin as an antitumor agent has been limited because of its association with problems such as lack of selectivity for cancer cells over normal cells, development of resistance to cisplatin treatment, and side effects such as nephrotoxicity. Recent studies on anticancer drugs have focussed on alternative anticancer agents such as gold compounds in both Au(I) and (III) oxidation states, which have shown to be potential anticancer drug agents because of their ability to induce apoptosis in several human cancer cells. Some gold complexes have shown to be able to selectively kill cancer cells over normal cells.
Anti-cancer drug
Apoptosis
Cytotoxicity
Cytoprotection
Gold(I) complexes
Thioredoxin
Lipid peroxidation
Oxidative damage
Phosphine ligands
Reactive oxygen species
2

Spectroscopie de luminescence et Raman de matériaux moléculaires cristallins et modélisation par la théorie de la fonctionnelle de la densité

Bélanger Desmarais, Nicolas 08 1900 (has links)
No description available.
Spectroscopie de luminescence
Spectroscopie Raman
Calculs DFT
Mesures à température variable
Mesures à pression variable
Complexes de l’or(I)
Complexes du platine(II)
Luminescence spectroscopy
Raman spectroscopy
DFT calculations
Variable-temperature measurements
Variable-pressure measurements
Gold(I) complexes
Platinum(II) complexes

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