Taiwan's small and medium enterprises (SMEs) play an important role to promote economic development. White paper on small and medium enterprises in Taiwan, 2004 indicated SMEs¡¦ numbers is 97.83% of whole industry. So SMEs is the main force in Taiwn¡¦s industry. According to National Science Council review SMEs in Taiwan engage in R¡®D activities facing the captial and technological barriers, and the percentage that accept government subsidy is 13%(National Science Council, 2000). The Deptartment of Industrial Technology (DOIT) of Ministry of Economic Affairs (MOEA), launched Taiwan's SBIR promoting program, mostly referred to the SBIR US version, in 1999 in order to encourage local start-up companies pursuing innovative research of industrial technologies and products. Rothwell & Zegveld (1982) research government innovation policy include technology and industry policy, classify three composes:Supply, Demand, and Environmential policy. In government R&D subsidy policy system can be distinguished to R&D procurement(Demand) and directive subsidy(Supply). The study compare to other country¡¦s R&D subsidy policy and refer to business technology strategy. The study uses the interview method to analyze the policy awareness of SMEs and confer the policy influence of SBIR subsidy policy. So far as bring up the suggestion of government R&D subsidy policy. Through interview analysis, SMEs represent in the beginning of R&D activities always face capital shortage and need technological assistance. The study propose government carry out R&D subsidy should replace monitoring control for concilling system. Government can match up national industry development way to alliance industry engage in specific R&D activity by government R&D subsidy policy. To sum up government can weighted the Demand and Supply side innovation policy to cooperate R&D subsidy policy system. So that government R&D subsidy policy can look after both side by stimulating SMEs innovation generality and promote national technology level to reach the full-scale policy achievements.