Master of Public Health - MPH / Background: The identification of undiagnosed HIV positive individuals through HIV testing services is one of the key measures in ensuring that the UNAIDS/ WHO 90 90 90 targets are achieved by the year 2020. The identification and subsequent initiation of HIV positive individuals on ART helps to minimise or prevent HIV transmission following viral suppression. Around 25% of people living with HIV globally are unaware of their positive status. In many countries, critical gaps exist in HIV services including prevention, testing and treatment. In Africa, the East and Southern region has a high burden of HIV/ AIDS where 50% of people are living with HIV, with 800,000 new infections in 2017. Despite concerted efforts in rolling out HIV testing services in Zimbabwe, a significant number of the population, especially men and young people, remain with an unknown HIV status, which is hindering progress towards the control and prevention of the HIV pandemic. A recent study confirmed that HIV testing in men is lower as compared to women. Consequently, progress is slower in trying to achieve the year 2020 milestone. The identification of suitable options for reaching out to these groups and the general population is important to achieve a reduction HIV prevalence. HIV self-testing oral fluid sample is thought to have the capacity to increase uptake of HIV testing. However, it still requires evidence on its acceptability and feasibility for those with undiagnosed HIV. Aim: The aim of this study was to explore the perceptions and experiences of the accessibility and feasibility HIV self-testing kits for individuals who received and used this method in Neta ward in Mberengwa District, Zimbabwe. The study identified some key factors that led to individuals accepting the kits and using them. The findings of this study will hopefully be able to inform policy makers’ decision-making about the importance of rolling out HST in the country.

<p>As of 2021, 38.4 million people worldwide are living with Human Immunodeficiency virus (HIV), with eastern and southern Africa having the highest prevalence. The efficacy of treatment is determined by identifying acute HIV infections (AHI) and prompting early antiretroviral therapy (ART) initiation to achieve viral suppression and reduce the risk of transmission. Existing rapid tests that detect host antibodies are affected by long seroconversions which allow the viruses to remain undetected until long after infection. On the contrary, highly sensitive nucleic acid amplification test (NAAT) based assays, serving as the gold standard for detection are restricted by their long turnaround time and high cost of implementation thus, restricting their use in low resource settings. Further, drug resistance cases and patient non-compliance to treatment may lead to HIV progression to aids; therefore, effective viral load monitoring is a critical component in the HIV care continuum. To address the gaps in viral load monitoring and early HIV detection, I propose to develop assays for handheld self-test platforms to detect low concentrations of HIV via two different approaches: 1) I will optimize an existing NAAT - based assay to semi-quantitatively detect HIV particles that were spiked in clinical samples and 2) I will Investigate the binding kinetics between HIV p24 antigen and Anti-HIV-1 p24 Antibody using the principle of Bio-layer Interferometry. Thus, I will lay the foundation for the development of a novel and highly sensitive p24 detection assay. Overall, this work will enable detection of ahi detection as well as support people living with HIV (PLHIV) management, all while remaining connected to healthcare and provider support. </p> <p><br></p>

The purpose of the study was to describe the determinants and practice of HIV self-testing among health care workers (HCWs) in Nyeri provincial hospital, Kenya. A descriptive cross-sectional study was conducted to determine the rate of HIV self-testing, explore the factors influencing the practice and describe access to HIV psychosocial support, care and treatment. The study was guided by the concepts of the protection motivation theory. Data was collected from 348 HCWs and analysed by means of logistic regression. Results showed that 65.8% of the HCWs had practiced HIV self-testing among themselves. Age, self efficacy and response efficacy were found to be significant predictors of HIV self-testing. Willingness to access HIV psychosocial support (71.3%) and care and treatment (73.9%) was high. Self-testing is highly practiced by HCWs. / HIV self-testing among health care workers at Nyeri Provincial Hospital in Kenya / HIV self-testing among health care workers / Public Health / M.A. (Public Health)

The purpose of the study was to describe the determinants and practice of HIV self-testing among health care workers (HCWs) in Nyeri provincial hospital, Kenya. A descriptive cross-sectional study was conducted to determine the rate of HIV self-testing, explore the factors influencing the practice and describe access to HIV psychosocial support, care and treatment. The study was guided by the concepts of the protection motivation theory. Data was collected from 348 HCWs and analysed by means of logistic regression. Results showed that 65.8% of the HCWs had practiced HIV self-testing among themselves. Age, self efficacy and response efficacy were found to be significant predictors of HIV self-testing. Willingness to access HIV psychosocial support (71.3%) and care and treatment (73.9%) was high. Self-testing is highly practiced by HCWs. / Public Health / M.A. (Public Health)