Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-05-31T15:07:36Z No. of bitstreams: 1 lucasvitorfonsecadeoliveira.pdf: 1420167 bytes, checksum: b5075b7ccc33c587012a46901a9b21af (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-02T12:44:37Z (GMT) No. of bitstreams: 1 lucasvitorfonsecadeoliveira.pdf: 1420167 bytes, checksum: b5075b7ccc33c587012a46901a9b21af (MD5) / Made available in DSpace on 2016-07-02T12:44:37Z (GMT). No. of bitstreams: 1 lucasvitorfonsecadeoliveira.pdf: 1420167 bytes, checksum: b5075b7ccc33c587012a46901a9b21af (MD5) Previous issue date: 2012-03-30 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Com a abertura legal do setor elétrico brasileiro na década de 90 para investimentos privados, em especial com a implantação sistemática de leilões para definição dos concessionários de transmissão, diversos estudos foram efetuados com o objetivo de viabilizar projetos de linha de transmissão de modo a concorrem nesses leilões. Grandes transmissoras, como Furnas, Chesf e Eletronorte promoveram pesquisas em consórcio com empresas construtoras de linhas e fabricante de ferragens e isoladores, com o objetivo de desenvolverem projetos com baixa relação Reais/MW transmitido. Neste cenário, muitos projetos de linhas de potência natural elevada foram idealizados e implantados, e como fruto desses projetos, publicações foram realizadas descrevendo os resultados obtidos. Todavia, apesar da quantidade, qualidade e riqueza das informações publicadas, a descrição do processo de otimização dos parâmetros elétricos da linha, em especial da impedância característica, não receberam destaque, sendo muita das vezes suprimida nos artigos. Neste sentido, este trabalho propõe a investigação de um método inovador de otimização da capacidade de transmissão de linhas de potência natural elevada, através da análise indireta dos efeitos da variação do posicionamento dos cabos condutores no feixe sobre a impedância característica da linha, por meio de uma abordagem original que utiliza basicamente o vetor de Poynting como função objetivo do Método de Otimização por Enxame de Partículas, sendo os campos elétricos e magnéticos necessários para definição do vetor de Poynting calculados por meio do Método dos Elementos de Contorno. O método foi validado utilizando como exemplos a otimização das configurações de feixes da linha de 500 kV Interligação Norte/SUL III – Trecho 2 e Linha de 500 kV Presidente Dutra / Teresina / Sobral / Fortaleza. Foram encontrados ganhos na capacidade de transmissão de 7% e 22% respectivamente devido à redução da impedância característica calculada após a otimização através da rotina Line Constants do programa ATP/EMTP, e comparando-a com os valores originais. / With the legal opening for private investments in the Brazilian energy sector in the 90's, in particular the systematic implementation of auctions for defining power transmission concessions, several studies were made with the aim of developing transmission line projects in order to compete in these auctions. Major transmission companies such as Furnas, Eletronorte and CHESF promoted consortium research with line builders and hardware and insulators manufacturers, in order to develop projects with low cost/MW transmitted. In this scenario, many projects of high surge-impedance loading lines were developed and implemented, and as a result of these projects, publications were made describing the results. However, despite the quantity, quality and resourcefulness of published information, the descriptions of the optimization process of electrical line parameters, especially regarding characteristic impedance, were not given prominence, being often suppressed from the articles. Thus, this study proposes the investigation of a method for optimizing the transmission capacity of high surge-impedance loading lines, varying the power cables in the bundle, indirectly reducing its characteristic impedance through an original approach that uses basically the Poynting's vector as objective function of the Particle Swarm Optimization method.The electric and magnetic fields needed for defining the Poynting vector were calculated using the Boundary Element Method. The method was validated through the optimization of bundle configuration, using as a model the characteristics of the 500 kV line North / South Interconnection III - Segment 2 and the 500 kV line Presidente Dutra / Teresina / Sobral / Fortaleza. It was found transmission capacity gains of 7% and 22% respectively, by reducing the characteristic impedance, which was calculated after the optimization using the EMTP/ATP Line Constants Program, comparing it with the original values.

This thesis focuses on gynecopathology. It consists of a collection of seven papers published in pathology journals with impact factor. Introduction section contains selection of examples showing scientific application of molecular genetic methods. Further on the aims of individual research projects are described. The first project comprises histomophologic study of skin endometriosis addressing "mullerian" differentiation. A case report of a rare tumor namely borderline papillary serous tumor of the fimbriated end of the fallopian tube follows with molecular genetic analysis of KRAS, BRAF and p53 gene mutation status. Prospective longitudinal study on high grade squamous dysplasia (HSIL) of the cervix in HPV vaccinated women, so called DAV (dysplasia after vaccination), aims to elucidate pathogenesis of this phenomenon. Two other studies focus on incidence of fumarate hydratase deficient leiomyomas of the uterus and hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC). The aim of those studies is to improve our diagnostic capability and increase detection rate of the patients with HLRCC syndrome. Finally a new subtype of HSIL namely bizarre cell dysplasia is described in two separate studies. Conclusion remarks contemplate the role of molecular genetics in surgical pathology.

This thesis focuses on gynecopathology. It consists of a collection of seven papers published in pathology journals with impact factor. Introduction section contains selection of examples showing scientific application of molecular genetic methods. Further on the aims of individual research projects are described. The first project comprises histomophologic study of skin endometriosis addressing "mullerian" differentiation. A case report of a rare tumor namely borderline papillary serous tumor of the fimbriated end of the fallopian tube follows with molecular genetic analysis of KRAS, BRAF and p53 gene mutation status. Prospective longitudinal study on high grade squamous dysplasia (HSIL) of the cervix in HPV vaccinated women, so called DAV (dysplasia after vaccination), aims to elucidate pathogenesis of this phenomenon. Two other studies focus on incidence of fumarate hydratase deficient leiomyomas of the uterus and hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC). The aim of those studies is to improve our diagnostic capability and increase detection rate of the patients with HLRCC syndrome. Finally a new subtype of HSIL namely bizarre cell dysplasia is described in two separate studies. Conclusion remarks contemplate the role of molecular genetics in surgical pathology.