Thesis (M.Med.Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 68-69). Also available in print.

Akademisk avhandling--Göteborg. / Extra t.p., with thesis statement, inserted. Bibliography: p. 197-208.

Thesis (M.S. Ed.)--Northern Illinois University, 2001. / Includes bibliographical references (leaves [33]-45). Also available online (PDF file) by a subscription to the set or by purchasing the individual file.

Thesis (M.S)--Rochester Institute of Technology, 2005. / Typescript. Includes bibliographical references (leaves 79-83).

Thesis (Doctoral)--Thüringischen Landesuniversität Jena, 1933.

Thesis (M.S.)--University of British Columbia, 2002. / Includes bibliographical references (leaves 90-97)

Thesis (M.S. Ed.)--Northern Illinois University, 2001. / Includes bibliographical references (leaves [33]-45).

München, Techn. Univ., Diss., 2004.

Amputation induces substantial reorganization of the body part somatotopy in primary sensory cortex (S1), and these effects of deafferentation increase with time. Determining whether these changes are reversible is critical for understanding the potential to recover from deafferenting injuries. Here, we report evidence that the representation of a transplanted hand and digits can actually recapture the pre-amputation S1 hand territory in two transplant patients. With limited sensation 4 months post operation, one of the patient's (D.S.) palmar tactile stimulation evoked contralateral S1 responses that were indistinguishable in location and amplitude from those detected in healthy matched controls. The other patient (M.S.) demonstrated not only much improved sensation but also recovered ability to localize tactile stimuli 120+ months after the operation. The results described suggest that even decades after complete deafferentation, restoring afferent input to S1 leads to re-establishment of the gross hand and digits representations within their original territory. Stimulation of the deafferented cortical maps may play an important role in maintaining their viability until the afferent input is restored. Motor imagery and creation of virtual visual feedback of the absent hand with a mirror have been proposed as stimuli. We used fMRI to record neural activity while 11 unilateral hand amputees and matched controls performed aurally-paced thumb-finger sequencing movements with their intact hand (matching hand in case of controls) under visual guidance during four conditions: 1) intact hand (ME), 2) ME with motor imagery of the amputated hand, 3) ME with virtual visual feedback of the amputated hand, and 4) ME with motor imagery and the virtual visual feedback of the amputated hand. In contrast to controls, amputees showed increases in activity during all four conditions within the former functionally-defined sensorimotor hand territory. Movements of the intact hand likely increase activity in the former hand territory as a result of decreased interhemispheric inhibition. This stimulation may maintain deafferented hand representations that can recover soon after the afferent input is restored by hand transplantation.

Made available in DSpace on 2015-01-26T13:21:25Z (GMT). No. of bitstreams: 0 Previous issue date: 1995-04-07Bitstream added on 2015-01-26T13:30:31Z : No. of bitstreams: 1 000026588.pdf: 1415996 bytes, checksum: 0508eba7f60bbbbab1f247054c7d1c08 (MD5) / Nesta pesquisa, com uma amostra de 207 indivíduos com idades variando de 4 anos a 12 anos, sendo 99 do sexo masculino e 108 do feminino, verificamos por meio de radiografias carpais, se há simetria ou assimetria bilateral no desenvolvimento entre as mãos direita e esquerda e se essas diferenças, quando presentes, influem no cálculo da idade óssea. Encontramos, quando somados os valores para ambos os sexos, simetria em 44,4% e assimetria em 55,5%, mas as variações de desenvolvimento que caracterizam assimetria, são muito pequenas e, portanto, concluímos que a avaliação da idade óssea pode ser feita por radiografias de qualquer uma das mãos, sem que haja diferença no cálculo da idade óssea / The objective of this research was to verify, by means of carpal radiography, the presence of asymmetries between the rigth and the left hands, and if the presence of asymmetry influences the estimation of osseous development. The sample used, comprised 207 individuals, 99 males and 108 females between 4 and 12 years of age. When both sexes were grouped we found symetry in 44,4% and asymmetry in 55,5% of the individuals evaluetad. However, the asymmetries verified were very subtle and were not sufficient to influence the osseous age. It was concluded that the evaluation of osseous age can be made in radiographs of both hands, without any significant difference