We investigated the role of muscarinic receptor subtypes at the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic neurogenic vasomotor tone, in mevinphos (Mev) intoxication. Adult Sprague-Dawley rats anesthetized by pentobarbital (45 mg/kg) and maintained by propofol (30 mg/kg/h) were used. Co-microinjection bilaterally of Mev (10 nmol) and artificial cerebrospinal fluid (aCSF) into the RVLM resulted in an increase (Phase I) followed by a decrease (Phase II) in the power density of the vasomotor components of systemic arterial pressure spectrum, our experimental index for sympathetic vasomotor tone. These changes in sympathetic vasomotor outflow in both phases of Mev intoxication were significantly and dose-dependently reduced on co-microinjection of Mev and the M2 subtype of muscarinic receptor (M2R) antagonist methoctramine (0.5 or 1 nmol) or M4R antagonist tropicamide (0.5 or 1 nmol). On the other hand, the M1R antagonist pirenzepine (0.5 or 1 nmol) or M3R antagonist 4-DAMP (0.5 or 1 nmol) was ineffective. Western blot analysis further revealed that the increase in NOS I protein levels at the RVLM during Phase I Mev intoxication or the augmented level of NOS II during both phases were significantly blunted on co-microinjection bilaterally of Mev and methoctramine (1 nmol) or tropicamide (1 nmol) into the RVLM. Pirenzepine (1 nmol) or 4-DMAP (1 nmol) was again ineffective. We conclude that both M2R and M4R subtypes in the RVLM may be involved in Mev intoxication. Whereas the prevalence of NOS I over NOS II at the RVLM during Phase I results in sympathoexcitation, sympathoinhibition induced by NO from NOS II in the RVLM is primarily involved in Phase II Mev intoxication.

In 1999 Japanese mobile operator NTT DoCoMo launched arguably the world’s first successful mobile Internet services portal called “i‐mode”. In Europe at the same time a series of failures diminished the opportunities to attract customers to the mobile Internet. Even though similar Internet technologies were available in Japan and the UK, very different markets for services developed during the initial years 1999‐2003. When the West expected Japanese firms to become dominant players in the mobile digitalisation of services during the introduction of 3G networks, it remained instead a national affair. The dominant views of how markets for mobile services operated seemed flawed.   So‐called delivery platforms were used to connect mobile phones with service contents that were often adapted from the PC world. Designing and operating service delivery platforms became a new niche market. It held a pivotal role for the output of services and competition among providers.   This thesis sets out to answer a set of inter‐related questions: How and where did firms innovate in this new and growing part of the service economy and how are new business models mediated by service delivery platforms? It argues that innovation in the digitalised economy is largely influenced by firms achieving platform leadership through coordination of both technological systems and the creation of multi‐sided exchanges. This thesis demonstrates from cases of multi‐sided markets in operator‐controlled portals, of mobile video and TV and of event ticketing in Japan and the UK that defining the scope of the firm on the network level forms the basis for incremental innovation, the dominant form of service innovation. A parallel focus on coordinating platform technology choices forms the basis for firms to trade fees, advertisements, and user data, enabling control over profitable parts of multi‐sided value networks.

No description available.

International meetings such as the G8 Summit have evolved from the sequestered gatherings of the economic elite to full-scale political media events. Using the 2005 Gleneagles G8 Summit as a case study, and focusing on one specific ‘autonomous’ activist network – Dissent! – this thesis investigates how the process of mediation is articulated in activists’ practices in preparing and enacting acts of contention. Dominant approaches to such events in the field of media and communications are often text-centred, focussing on the media’s framing of protest, overlooking the actions against and interactions with the media at such sites. This oversight is significant given that contemporary political struggle occurs on the ground, as well as with and through the media. The theoretical framework applies past media/movement scholarship to emerging discourses on mediation which view media – its content, producers, users, technologies, culture and rituals – as an ongoing and reflexive process, actualised through analysing activists’ media-oriented practices (Couldry, 2004, Silverstone, 2005). The methodological approach follows Burawoy’s (1998) “extended method” drawing on a year of participant observation and 32 in-depth interviews. Analysis is undertaken on an activist, group and network level; before and at the Summit. The findings show that activists demonstrate a reflexive awareness of media, including lay theories of media which inform their actions. On a networklevel, Dissent! established a policy abstaining from media interaction. Yet, despite this, on a group-level, the CounterSpin Collective formed within Dissent! to manage media interest. The Collective’s media practices are shown to be characterised by a strategy of dual adaptation; adapting to both Dissent!’s political limitations and the media’s demands. The analysis of the site of protest in Scotland – Hori-Zone eco-village – and the protest actions undertaken from it, further demonstrates the way in which media orients and permeates activists practices. The concept of spectacular action is developed to analyse a shift in the type of protest activities conducted at a media event from direct action to the simulation of direct action, valuing symbolic over physical disruption. This thesis contributes to a growing interest in the concept of mediation through the emerging field of media practice, offering both empirical evidence and revised theory. Moreover it addresses the largely neglected role of the media in social movement literature. Research undertaken also demonstrates how the logic of media now permeates the practice of activism, marking the rise of spectacular action as a cause for concern for both activists and academics.

Practices commonly termed participatory or citizen journalism, such as blogging and publishing content in participatory news media, have triggered interest in academic and media discourses alike. The discussion has centred on the significance of participatory journalism and whether it leads to democratisation of media and to redefining journalism and its ethics. This thesis examines online participatory journalism practices and what enhances or impedes them by drawing on a close and systematic analysis of qualitative interviews with reporters and facilitators of participatory media. The research considers both the meso level of media organisations in their socio-cultural context and the micro level of reporters, and is comparative and transcultural in scope. The focus is on the international edition of the South Korean news organisation OhmyNews and on two Indymedia collectives, namely, Indybay in California in the USA and the no-longer active Vaikuttava Tietotoimisto in Finland. The study employs Dahlgren’s (2009) analytic frame of civic cultures that, although it downplays skills and somewhat problematically assumes equal weight of all dimensions, proved valuable in addressing several key aspects to participatory journalism as a mode of civic engagement. The research demonstrates how reporters’ journalistic activities do not exist in a vacuum, but are shaped by participatory media organisations, for example, through the values they promote and the type of journalism, the access to sources and training they facilitate. Furthermore, the thesis argues that participatory media practices are less distinct from those of mainstream media than may have been assumed. Underpinning the analysis of media organisations are the theories of alternative media and of voluntary associations, whereas Mouffe’s (2000a) political theory of agonistic pluralism is applied to assess the viability of an agonistic space online. The findings, apart from the instances of its constructive uses, point toward the difficulties in sustaining an agonistic online space.

This dissertation contains two studies that investigate the Mesozoic and Cenozoic tectonics of the western USA. The first study investigates shortening in the Sevier thrust belt of northeast Utah and southwest Wyoming. Cross section restoration suggests that there was ∼8-14 km of pre-Absaroka-thrust shortening above the Jurassic Preuss salt detachment (PSD), but not below it, in the hanging wall of the Absaroka thrust. Reflection seismic data show that the Crawford thrust is not offset along the PSD, indicating that the additional shortening on the Absaroka plate was transferred east before main movement on the Crawford thrust. Integration of surface and subsurface geology suggests slip from the Willard or Lost Creek thrust was transferred several tens of kilometers east along the PSD between ∼102-90 Ma.The second study investigates the low-temperature thermochronology of the Laramide Ranges. We dated 91 borehole and surface samples from basement-cored uplifts of the Rocky Mountain foreland (Wind River, Beartooth, Bighorn and Laramie Ranges), and the Uncompahgre Uplift, using the apatite (U-Th)/He system. (U-Th)/He ages generally increase with increasing elevation. Most samples show age dispersion of tens to hundreds of Myr. Several samples show correlations between (U-Th)/He age and effective U concentration (eU = [U] + 0.235[Th]), indicating that radiation damage has affected (U-Th)/He age. Many surface and near-surface samples have (U-Th)/He ages that are older than apatite fission-track ages.Forward and inverse modeling using a radiation damage diffusion model showed that (U-Th)/He ages may be widely dispersed, and may be older than apatite fission-track ages within a fossil partial retention zone. Most samples, however, do not exhibit the predicted (U-Th)/He age-eU correlation. We show that the effects of grain size can obscure (U-Th)/He age-eU correlations. Best-fit thermal histories from the inversion of age-eU pairs were extrapolated to other elevations to create model age-elevation plots. "Too-old" (U-Th)/He ages that are not within a fossil partial retention zone are likely due to He implantation from high-eU phases. Inverse modeling of (U-Th)/He age data suggests that rapid exhumation within the Laramide province began earlier in the Bighorn Mountains (before ∼71 Ma) than the Beartooth Range (before ∼58 Ma).

This is a case study in the microsociology of knowledge conducted in the London-based News Division of the British Broadcasting Corporation during 1972-3. The data was gathered by fieldwork in Broadcasting House and Television Centre. The study falls into two parts. The first, after a review of relevant literature, presents a detailed account of those dimensions of the organisational milieu necessary for an understanding of broadcast news production. These are: the hierarchical control structure which determines policy for news coverage; the everyday production routines which structure “news” as an organisational product; the system of advanced planning through which news stories are identified. This section also locates the legitimising role played by the BBC’s editorial philosophy and power structure, and considers implications of the broadcaster’s conventional distinction between “news” and “current affairs”. The second part of the study develops the idea of news producers as constituting and epistemic community whose work skills, organisational location, and occupational knowledge give them a distinctive cognitive orientation. Newsmen’s characterisation of their thought and practice as “professional” is analysed as a mode of conferring authority upon the production process, and the product “news”. It is then argued that newsmen’s primary framework of reference is the organisation within which they assert their complete autonomy from the audience, while at the same time asserting their unique capacity to determine its needs for news. Next, “impartiality” is analysed as a distinctive corporate conceptions drawn from a model of the political consensus represented by the major Parliamentary political parties, and is presented as illus-trating the BBC’s accommodation to the realities of State power. Newsmen’s claim to be accurate is next considered. It is shown how they support their claim by pointing to empiricist methods of authentication. The specific character of these is demonstrated by showing how news production is heavily condition-ed by the temporal imperatives of the daily news cycle. The study then concludes after considering newsmen’s time-conscious-ness; their professionalism in this context is analysed as being in control of the pace of often unpredictable work.

This thesis contributes to our understanding of the role of European Union policy in national level governance of the audiovisual media sectors in small states in South East Europe. It compares the Republics of Slovenia and Macedonia, two countries of similar size and population that emerged from the same former-Yugoslav media system. Slovenia is a new EU member state and Macedonia is a candidate country, therefore both are formally bound by EU audiovisual media policy. Europeanization research, particularly in new Member States and candidate countries, has focused on compliance with transposition deadlines and the implementation of specific EU Directives. This study takes a bottom-up approach, making media governance its object of study based on a conceptualisation of governance by Jan Kooiman (2003), but still focused on identifying the role of the EU within that national level governance. It draws on interviews with stakeholders in both countries, examination of secondary data available on the respective media markets, and accounts from civil society actors and regulators to arrive at an overall picture of media governance. It finds that in these two cases the role of Europeanization, defined in this thesis in relation to the EU, centres on the use of EU rules by domestic actors in order to forward their strategic interests. It argues that the media sectors in these two cases are largely resistant to Europeanization because of their small size and the particular relations between media and political elites. This thesis suggests that the media sector may be different from other sectors such as transport, environmental protection, or labour in terms of Europeanization and governance because the role of media in domestic politics. However, this is not a simple story of the democratic and governance failures often attributed to Southern European countries. This thesis shows the complexity in which Europeanization takes place, and highlights the importance of market conditions and market players to this process.

Syre transporteras från lungorna, via blodet bundet till erytrocyternas hemoglobin, till kroppens alla celler. En hemoglobinkoncentration i blodet under referensintervallet definieras som anemi och påverkar hela kroppen och försämrar den fysiska prestationsförmågan. Järnbristanemi är en anemi med otillräcklig järntillförsel till benmärgen på grund av tomma järnförråd (absolut järnbrist) eller försvårat järnutnyttjande (funktionell järnbrist). Analysparametern HYPO på analysinstrumentet Advia 2120 (Siemens) mäter andelen hypokroma erytrocyter (erytrocyter med lågt hemoglobininnehåll) och anses vara en av de bästa parametrarna för att påvisa funktionell järnbrist. Analysparametern Hypo-He på analysinstrumentet XN-1000 (Sysmex) är en forskningsparameter för samma ändamål. Syftet med detta arbete var att jämföra markörer för funktionellt järnstatus och utvärdera om analysen HYPO på Advia 2120 kan ersättas med Hypo-He på XN-1000. Fyrtiofyra patientprover, på vilka HYPO var beställt, analyserades, först på XN-1000 och därefter på Advia 2120. En linjär regressionmodell gjordes för att beskriva korrelationen mellan analyserna HYPO och Hypo-He. Imprecisionen för analysen Hypo-He beräknades genom inom-serie- och total-serie-imprecision. Korrelationen mellan analyserna var måttligt stark (r = 0,7185 (absoluta värden) och r = 0,8081 (logaritmerade värden)), dock med många analysresultat inom det lägre området. Variationskoefficienten för Hypo-He beräknades till mellan 0 % - 9,5 %. För att kunna avgöra om Hypo-He kan ersätta HYPO som indikator på funktionell järnbrist krävs kompletterande studier på välkaraktäriserade patientprover med varierande analysvärden inkluderande värden för HYPO på mer än 10 %.

This thesis will argue that there is a mismatch between the information children are receiving about crossing roads from parents, schools and safety programs and the information they gain from their own experiences and from their observations of adult pedestrians. Initial observations suggested that two features of children's behaviour on the roads lead to their greater liability to have accidents as pedestrians. Children can often be seen to enter the carriageway without paying attention to the traffic - this behaviour, popularly called "heedlessness", appears frequently in accident report forms as an explanation of the accident. Secondly, children can often be seen to behave inefficiently, hesitating, making false starts and running dangerously close to cars, when they are apparently fully aware of the traffic. This behaviour is best described as lacking in skill. The studies, to be reported, relate measures of children's road crossing behaviour to measures of their accident risk. They reveal basic differences in the way children behave on busy, major roads and on quiet, minor roads. There is little evidence of "heedless" behaviour on major roads, where children generally are fully aware of what they are doing, but the children use different crossing strategies to adults. There is a contradiction between the way children are instructed to cross these roads and the way in which experienced pedestrians cross. Whereas, for example, children are instructed to stop at the kerb before starting to look for traffic, adults seldom arrive at the kerb without previously having assessed the crossing situation. Children do however develop these more efficient, adult crossing strategies in spite of the training programs. Children behave quite differently on quiet, minor roads. Here, there is more evidence of "heedless" type behaviour, and since quite frequently these roads are being used by the children as an extension of the pavement, it is unrealistic to expect them to behave otherwise. Conventional road safety instruction in this situation seems inappropriate. An approach for reducing accidents is proposed, the effectiveness of which could be assessed by the behavioural and risk measures developed in the study. A greater awareness of the different problems associated with crossing major and minor roads is required. On major roads we should aim for a greater segregation of children and traffic, they should be easily identifiable, and instructions for crossing them made more relevant. On minor roads it must be accepted that conventional safety instruction is inappropriate, and an alternative approach must be found. It is suggested that the role of the driver is a greatly neglected factor here, and that drivers should be encouraged or forced to drive more responsibly in areas with high densities of children.