Thesis (Ed. D.)--Illinois State University, 2004. / Title from title page screen, viewed November 17, 2005. Dissertation Committee: Robert L. Fisher (chair), Marilyn Moore, Marilyn Morey, Deborah B. Gentry. Includes bibliographical references (leaves 130-140) and abstract. Also available in print.

Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 189-196).

Bachelor-Arbeit Univ. St. Gallen, 2008.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1969. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Wisconsin, 1963. / Typescript (carbon copy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 41-43).

Thesis (M. Phil.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.

Thesis (M.S.)--Oregon State University, 2008. / Printout. Includes bibliographical references (leaves 161-171). Also available on the World Wide Web.

Thesis (Psy. D.)--Wheaton College Graduate School, 2008. / Abstract. Includes bibliographical references (leaves 41-42).

Submitted by INGRID DA SILVA SANTOS null (iingridsantos@hotmail.com) on 2017-06-26T03:09:39Z No. of bitstreams: 1 Dissertação de Mestrado_Repositório UNESP_INGRID DA SILVA SANTOS.pdf: 1875360 bytes, checksum: b760f2a2958eb68922d78501172c5f4e (MD5) / Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-06-28T16:45:33Z (GMT) No. of bitstreams: 1 santos_is_me_araca_par.pdf: 1437951 bytes, checksum: 9bb3ef4b8f15e4259996185982c7950e (MD5) / Made available in DSpace on 2017-06-28T16:45:33Z (GMT). No. of bitstreams: 1 santos_is_me_araca_par.pdf: 1437951 bytes, checksum: 9bb3ef4b8f15e4259996185982c7950e (MD5) Previous issue date: 2017-06-02 / Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM) / Evidências sugerem que o papilomavírus humano (HPV) está associado com um subgrupo de carcinomas de células escamosas da cabeça e pescoço (HNSCC). No entanto, a prevalência do HPV varia substancialmente dependendo do local anatômico e da região geográfica estudada. Aqui, nosso objetivo foi investigar a prevalência do HPV em amostras de tecido fresco de pacientes brasileiros com carcinoma de células escamosas (CEC) de boca e orofaringe combinando dois métodos confiáveis para a detecção do HPV. Foram recrutadas trinta e seis amostras de tecido fresco provenientes de CEC de boca (n= 27) e orofaringe (n= 9) para análises. As características sociodemográficas, estilo de vida e clinicopatológicas foram coletadas através dos prontuários. O DNA do HPV foi detectado por dois métodos: reação em cadeia da polimerase (PCR) em tempo real através de ensaio qualitativo de presença ou ausência do HPV-16, e testado para 37 genótipos usando Linear Array. A amplificação do gene β -globina funcionou como controle interno positivo para a análise do DNA em todas as amostras. O DNA do HPV não foi detectado em nenhum dos casos de amostras de tecido de pacientes com CEC em ambos os métodos utilizados. A ausência do HPV observada em nosso estudo pode sugerir que este não é um fator de risco prevalente nos CECs de boca e orofaringe nesta região geográfica. Os fatores de risco clássicos para o desenvolvimento desses tumores parecem ser ainda a principal causa nessa população brasileira. Investigações detalhadas do estilo de vida com maior amostragem precisam ser melhor exploradas para compreensão da baixa prevalência encontrada. / Evidence suggests that human papillomavirus (HPV) is associated with a subgroup of squamous cell carcinomas of the head and neck (HNSCC). However, the prevalence of HPV varies substantially depending on the anatomical site and geographic region studied. Here, our goal was to investigate the prevalence of HPV in fresh tissue samples from Brazilian patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by combining two reliable methods for the detection of the HPV DNA. We recruited thirty-six fresh tissue samples from SCC of the oral cavity (n= 27) and oropharynx (n= 9) for analysis. The sociodemographic, lifestyle and clinicopathological characteristics were obtained from individual medical records. HPV DNA was detected by two methods: real-time polymerase chain reaction (PCR) through the qualitative assay of presence or absence for HPV-16, and tested for 37 genotypes by the Roche Linear Array. Amplification of the β-globin gene functioned as a positive internal control for DNA analysis in all samples. HPV DNA was detected in none of the tissue samples from patients with SCC in both methods. The absence of HPV observed in our study may suggest that this is not a prevalent risk factor in SCC of the oral cavity and oropharynx in this geographical region. The classic risk factors for the development of these tumors seem to be still the main cause in this Brazilian population. Detailed investigations of lifestyle with larger sample needs to be better explored to understand the low prevalence found. / FAPEAM: 120/2015

The primary goal of the American football helmet has been protection of players against skull fractures and other traumatic brain injuries (TBI) [Cantu 2003, Benson 2009]. TBI can result from short, high magnitude linear impact events typical of when the head impacts a hard surface [Gilcrhist 2003, Doorly 2007]. The modern helmet, which has evolved and become well designed to mitigate TBI injuries, does not offer sufficient protection against injury such as concussion, and the incident rate remains high in sport [Broglio 2009, Rowson 2012]. Researchers speculate rotation of the head leads to shear strain on the brain tissue, which may be the underlying mechanism of injury leading to concussive type injuries [Gennarelli 1971, Ommaya 1974, Gennarelli 1982, Prange 2002, Gilcrhist 2003, Aare 2003, Zhang 2004, Takhounts 2008, Greenwald 2008, Meaney 2011]. This has led researchers to investigate new liner materials and technologies to improve helmet performance and include concussive injury risk protection by attempting to address rotational acceleration of the brain [Mills 2003, Benson 2009, Caserta 2011, Caccese 2013]. To improve current football helmet designs, technology must be shown to reduce the motion of the brain, resulting in lower magnitudes of dynamic response thus reducing maximum principal strain and the corresponding risk of injury [Margulies 1992, Zhang 2004, Mills 2003, Kleiven 2007, Yoganandan 2008 Caserta 2011, McAllister 2012, Caccese 2013, Post 2013, Fowler 2015, Post 2015a/b]. Recent research has studied the use of decoupling liner systems in addition to the existing liner technology, to address resultant rotational acceleration. However, none of this previous work has evaluated the results in terms of the relationship between brain motion, tissue strain, and injury risk reduction. This thesis hypothesises the use of decoupling strategies to reduce the dominant coordinate component of acceleration in order to decrease maximum principal strain values. The dominant component of acceleration, defined as the coordinate component with the highest contribution to the resultant acceleration for each impact, is a targetable design parameter for helmet innovation. The objective of this thesis was to demonstrate the effect liner strategies to reduce the dominant component of rotational acceleration to decrease maximum principal strain in American football helmets.