No description available.

No abstract available. / Thesis (M.A.)-University of Durban-Westville, 2001.

No description available.

Rats learn to navigate to a specific location faster in a familiar environment (Keith and Mcvety 1988). It has been proposed that place learning does not require specific reward signals, but rather, that it occurs automatically. One of the strongest pieces of evidence for the automatic nature of place learning comes from the observation that place and head direction cells reference their receptive fields to prominent landmarks in an environment without needing a reward signal (O’Keefe and Conway 1978; Taube et al. 1990b). It has also been proposed that an allocentric representation of an environment would be bound to the landmarks with the greatest relative stability to guide its orientation (O’Keefe and Nadel 1978). The first two parts of this thesis explore whether place and head direction cells automatically use the most coherent landmarks for orientation. Head direction cells have been shown to orient their preferred firing directs coherently when being exposed to conflicting landmarks in an environment (Yoganarasimha et al. 2006). A model of head direction cells was thus used to explore the necessary mechanisms required to implement an allocentric system that selects landmarks based on their relative stability. We found that the simple addition of Hebbian projections combined with units representing the orientation of landmarks to the head direction cell system is sufficient for the system to exhibit such a capacity. We then recorded both entorhinal head direction cells and CA1 place cells and at the same time subjected the rats to repeated experiences of landmark conflicts. During the conflicts a subset of landmarks always maintained a fixed relative relationship with each other. We found that the visual landmarks retained their ability to control the place and head direction cells even after repeated experience of conflict and that the simultaneously recorded place cells exhibited coherent representations between conflicts. However, the ’stable landmarks’ did not show significantly greater control over the place and head direction cells when comparing to the unstable landmarks. This argues against the hypothesis that the relative stability between landmarks is encoded automatically. We did observe a trend that, with more conflict experience, the ’stable landmarks’ appeared to exert greater control over the cells. The last part of the thesis explores whether goal sensitive cells (Ainge et al. 2007a) discovered from CA1 of hippocampus are developed due to familiarity with the environment or from the demands for rats to perform a win-stay behaviour. We used the same win-stay task as in Ainge et al. and found that there were few or no goal sensitive cells on the first day of training. Subsequent development of goal sensitive activity correlated significantly with the rat’s performance during the learning phase of the task. The correlation provides support to the hypothesis that the development of goal sensitive cells is associated to the learning of the win-stay task though it does not rule out the possibility that these goal sensitive cells are developed due to the accumulated experience on the maze. In summary, this thesis explores what kind of spatial information is encoded by place and head direction cells and finds that relative stability between landmarks without a reward signal is not automatically encoded. On the other hand, when additional information is required to solve a task, CA1 place cells adapt their spatial code to provide the necessary information to guide successful navigation.

Anatomical changes can have significant clinical impact during head and neck radiotherapy. Adaptive radiotherapy (ART) may be applied to account for such changes. Implementation of ART to alter dose delivery requires deformable image registration (DIR) to assess 3D deformations. This study evaluates the performance and accuracy of a commercial DIR system for clinical applications. The investigations in this project were carried out using images of induced changes in two standard radiotherapy phantoms (RANDO® and CIRS®) and one in-house built phantom. CT image data before and after deformation of the phantoms were processed using Eclipse / SmartAdapt® v.10 system employing a Demons-based algorithm. A DIR protocol was designed, and algorithm performance was assessed quantitatively, using volume analysis and the Dice Similarity Index (DSI), and also evaluated qualitatively. In addition, algorithm performance was assessed for 5 head and neck cancer patients using clinical CT images. Each original planning CT image containing contours of 10 volumes of interest including treatment target volumes and organs at risk was deformed to match a second CT image acquired during the course of the treatment. The original structures were deformed, copied onto the target image and compared to reference contours drawn by 3 radiation oncologists. Phantom investigations gave varied results with average DSI scores ranging from 0.69 to 0.93, with an overall average of 0.86 ± 0.08. These quantitative results were reflected qualitatively, with generally accurate matching between reference and DIR-generated structures. Although air gaps in the phantoms compromised algorithm performance and gave rise to physically aberrant results. Clinical results were generally better with a DSI range of 0.75-0.99 and an overall average of 0.89 ± 0.05, suggesting high DIR accuracy. Qualitatively, some minor contour deformations were noted, as well as artefacts in the axial direction that were due to the CT slice resolution (3 mm) that was used to scan the patients. In addition, contour propagation between images using DIR reduced the time required by physicians to contour the images of head and neck cancer patients by ~47%. This study demonstrated that deformable image registration using a Modified Demons algorithm yields clinically acceptable results and time-saving benefits in contouring that improve clinical workflow. The study also showed that it is feasible to incorporate deformable image registration as part of an adaptive radiotherapy strategy for head and neck cancer, provided further studies are designed to carry out accurate and verifiable dose deformation.

No description available.

Clinical neuropsychologists who assess patients following mild closed head injury (CHI) are often asked to offer an opinion whether there is evidence of malingering. Factors that impact the ability of a person to intentionally portray impairment are quite important since mis-diagnosis of malingering can result in delayed treatment. In this study knowledge of the sequelae of mild CHI was provided to normal college students in an effort to change reporting of symptoms and influence the type of malingering strategy used when completing the Neuropsychological Symptom Inventory (NSI). Subjects were randomly assigned to either a prior knowledge malingering group (PK;N=57), no prior knowledge malingering group (NPK;N=58), or control group (CON;N=61). The results showed that PK subjects endorsed more general and attention/concentration symptoms than NPK or CON subjects. The results also showed PK subjects were as likely to be detected by the NSI lie scale as NPK subjects. Thus, the NSI lie scale demonstrated sensitivity to malingering despite subjects having brief instruction about mild CHI. Also, having prior knowledge did not result in significantly different strategies when completing the NSI. Instead, both malingering groups reportedly used exaggeration and attempted to be consistent as frequent strategies. / Department of Educational Psychology

Magnetic neural stimulation of straight neurons with bends (1) in a semi-infinite volume conductor with a planar interface and (2) in the model of the human head is analyzed. Two stimulating coils, namely the double-square and the double circular, producing the magnetic field for the neuron stimulation are considered. The results indicate that the stimulating coil characteristics (size, shape and location) and the neuron shape affect the magnitude and location of the stimulation. The activating function, defined as the electric field derivative along the neuron, has two components. One component depends on the derivative of the electric field along the straight section of the neuron, and the other on the field magnitude. For bent neurons in a semi-infinite volume conductor, an analytical expression of the activating function (the stimulus) of the neuron was derived. The maximal stimulation point is at the bend of the nerve and its position depends on the nerve shape and coil parameters. The analysis also shows a better performance (a stronger stimulus) for a double-circular (figure eight) coil than for a double-square coil of comparable size. Stimulating bent neurons in the human head is also analyzed. The head model consists of an outer sphere representing the skull and scalp and two inner spheres such that each represents one half of the brain. The 3D-impedance method was used to obtain the induced electric fields by the double-square and double-circular coils. Quasi-static conditions are assumed. The geometry of the neuron in this model approximates the normal configuration of motor neurons in the human head. The analysis shows that the stimulation occurs almost at the highest point on the nerve (the closest point to the coil) with the coil positioned in such a way that its center is directly over the highest point on the nerve. It is also shown that the double-square coil produces a stronger stimulus than the double-circular coil. This result is in contradiction with that for a bent neuron in a semi-infinite volume conductor, however, it agrees with the results obtained for a straight neuron [1]. The analysis of bent neurons represents a more realistic approximation of the actual anatomy. The results of this analyses confirms the conclusions and, therefore, usefulness of simplified analyses of straight neurons. The results are expected to be of some use in clinical applications where non-invasive neural stimulation is desired and location of stimulation needs to be known. / Graduate / 0544

The value of heads of department in the management of their departments and the school is currently not fully utilised or taken into consideration by the different role players in education. In many cases the appointment as head of departments is rather experienced as just another level in the educator's career to become a principle. The specific responsibilities and roles, coupled to this post, are not fully realised. The effectiveness of heads of departments as appointed managers in the school can only by determined through the degree in which they can provide guidance. The training of managers is traditionally placed in the forefront, but in changing times and progress rather endeavours to find a leader who can activate, motivate and effectively communicate. The objective of this research is to determine which roles in education are fulfilled by heads of department as leaders, and to what degree there is a need to develop the leadership skills of heads of department. To achieve the objective of the research, it was necessary to firstly determine what leadership roles, functions and skills are expected of heads of department in secondary schools and why leadership development for heads of department is important. A literature study on the determinants of leadership in general and applicable to the head of department was then done. Focus was also placed on the models used to determine leadership training of heads of department. After a questionnaire was distributed to representative secondary schools in the Potchefstroom and Klerksdorp districts and responses statistically analysed, was it possible to draw a number of correlations and make recommendations. iii The general impression created by the results was that heads of department do have a need for the development of their leadership skills. The cause of this is in all probability the dynamic nature of the education environment in South Africa and the lack of effective leadership in the management of change. The deduction can justly be made that it is essential that formal attention by paid to now and in the future. The training of teachers must without a doubt deal with elements of leadership. When the preceding requirements are met and when the Department of Education continuously present empowerment workshops on this subject, it will definitely lead to more effective and heads of department. / Thesis (M.Ed.)--North-West University, Potchefstroom Campus, 2005.

The objective of this research was to better understand how impact angle influences headform dynamic response and brain tissue deformation. A bare headform was impacted using a pneumatic linear impactor at 5.5 m/s. The impacts were directed on the front and side location at angles of 0, 5, 10 and 15° rightward rotations as well as -5, -10 and -15° (leftward) rotations at the side to examine the characteristics of the head and neckform on the results. Peak resultant linear and rotational accelerations from the headform as well as peak maximum principal strain (MPS) and von Mises stress (VMS) estimated from a brain finite element model were used to measure the effect of impact angle. Significant results were dependent upon the impact angle and location as well as the dependent variable used for comparison (p <0.05). Impact angle produced significant differences in rotational acceleration and MPS at both the front and side; however angle only had an effect on VMS and linear acceleration at the front and side locations, respectively. These findings show that the effect of impact angle is asymmetrical and is specific to the dependent variable. This study suggests that varying impact angle alone may not be as influential on headform dynamic response and brain tissue deformation and that the severity of an impact may be more of a function of how both location and angle create high risk conditions.