Objectives : To investigate the impacts of traffic related air pollution (TRAP) on children’s respiratory health, and to investigate the policies and regulations implemented in other countries and the suggestions from the World Health Organization (WHO) to tackle this problem. Methods and Results: Using relevant keywords, 122 articles were acquired from PubMed and 15 were from MEDLINE via EBSCO host respectively. The articles were published between 1980 to 2013; all of which had examined the impacts of TRAP on children’s respiratory health. After assessing inclusion and exclusion criteria, 9 articles were finally included in this systematic review. Differences in demographic characteristics were studied and compared to determine the association between TRAP exposure and respiratory health impacts on children aged between 1 and 18. Four cross-section surveys and five cohort studies were selected in this review. The association between TRAP exposure and differences in children’s respiratory impacts were demonstrated in all studies. Multiple outcome measures were used to examine changes of children’s respiratory health such as the decline in lung function, incidences of asthma and inflammatory responses. There were 4 out of 9 articles suggesting the decline in lung function was related to TRAP exposure; 5 out of 9 articles showed the relationships between incidences of asthma and inflammatory responses and TRAP exposure and 2 articles mentioned other respiratory symptoms; notably, wheezing and sneezing, runny and stuffed nose. This review finally summarized the results of selected articles stressing that children who lived close to roadway within a 500 meter radius from home, with an early exposure to air pollution in the first year of age and a frequent exposure to heavy road traffic and outdoor air pollutants would experience greater impacts on respiratory health. Conclusion: The positive association between the impacts on children’s respiratory health and TRAP exposure has been determined through this systematic review. Stricter emission control strategies and updated guidelines are required to regulate traffic emission and improve air quality in order to reduce harm and provide a better living environment for our next generations. / published_or_final_version / Public Health / Master / Master of Public Health

Background Chronic smokers are at risk of premature death associated with underlying pulmonary or cardiovascular diseases. Dual influenza and pneumococcal vaccination has been shown to prevent death and hospitalization secondary to pulmonary or cardiovascular diseases in elderly persons. Its effect in chronic smokers remained unknown. Methods This is a prospective randomized open-labeled trial conducted from April 2010 to March 2013, comprising adult patients aged less than 50 years who were chronic smokers. Subjects were randomly assigned into 4 groups. Group 1 (study group) patients received both trivalent influenza vaccine (TIV) and the 23-valent polysaccharide pneumococcal vaccine (PPV). There were 3 control groups: Group 2 patients received the TIV only. Group 3 patients received the PPV only and Group 4 patients did not receive any vaccines. The TIV used was the Vaxigrip® (Sanofi Pasteur, France) and the PPV used was the Pneumovax®23 (Merck, USA). All enrolled patients were follow-up for 24 months post vaccination. Patient details, Charlson comorbidity index, medications, subsequent hospitalization, diagnosis and mortality were recorded and analyzed. Results A total of 1006 subjects were enrolled and completed the study (Group PPV+TIV: 250; Group TIV: 254, Group PPV: 250 and Group None: 259). The baseline demographics and Charlson comorbidity index were similar among subjects in the 4 groups. The median age was 48 years and 85.9% were male patients. Significantly fewer subjects who received the dual vaccination (Group PPV+TIV) were hospitalized (p<0.001), with shorter mean length of stay (p<0.001), and less frequent hospitalization (p<0.001) for cardiovascular or respiratory diseases than no vaccination (Group None) or single vaccination (Group TIV and Group PPV). Multivariate analysis demonstrated that dual vaccination with PPV + TIV was the only independent factor associated with reduced risk of hospitalization (p<0.001; relative risk 0.288; 95% CI 0.101-0.154). There was no difference in mortality rate among the groups. Both vaccinations were well tolerated and no serious adverse events were reported. Conclusion Dual influenza and pneumococcal vaccinations prevented chronic smokers against hospitalization secondary to pulmonary or cardiovascular causes. Annual influenza and a single pneumococcal vaccination should be promoted among chronic smokers. / published_or_final_version / Microbiology / Master / Master of Medical Sciences

Voice problems are common among teachers due to their job characteristics. Thus, the quality of teaching, daily communication, emotion would be adversely affected. However, the past studies mainly focused on primary school and preschool teachers. There is lack of investigation on voice problems of secondary school teachers. Moreover, the need for voice use training for secondary school teachers was not addressed in the past. This study investigated the prevalence of voice problems in secondary school teachers in Hong Kong and the need for preventive education. A questionnaire was decided with domains in demographics, job natures, impact on voice disorders, risk factors, history of seeking help because of voice problems, view on different treatment options and opinion towards the need of voice protection training. Subjects were recruited from four local secondary schools in Hong Kong. 85 questionnaires were collected and analyzed. The results showed a high prevalence of voice disorders (75%) among secondary school teachers. Also it revealed different levels of impact on work performance, emotion and daily communication. Laryngitis was the only risk factor found to be significantly correlated with the voice disorder. On the other hand, the rate of seeking professional help and their knowledge about voice rehabilitation were low. Most of the respondents realized the need for voice protection training. It suggested that the voice problems of secondary school teachers should be highlighted and more voice protection information and voice training should be provided. / published_or_final_version / Surgery / Master / Master of Medical Sciences

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Léonard Lessius was a Flemish Jesuit whose published works engaged in the most pressing economic, theological, and philosophical debates of the late sixteenth and early seventeenth-centuries. Highly-respected for both his profound intellect and his exemplary integrity and virtue, Lessius, also known as "The Prince of Philosophers" was venerated even in death. Despite his remarkable fame and influence in his own day, Lessius' philosophical contributions and legacy have been largely forgotten by modern historians. This striking lacuna in the historiography illuminates the narrow categories and concerns as well as the serious limitations of modern philosophy and the history of philosophy in particular. This report narrows in on one of these lost philosophical fields and treatises in particular, Lessius's study on diet and health, Hygiasticon (Antwerp, 1613). It uniquely, and quite literally, gets at the heart and soul of early modern philosophy: what is natural, what is the relationship between body, mind and soul, and what is necessary for health, wealth, spiritual- and self-improvement. / text