A dissertation presented in partial fulfilment of the requirements for the Masters Degree in Technology: Chiropractic, Durban University of Technology, 2006. / The aim was to evaluate the prevalence of hand and wrist pain, as well as the relationships between occupational overuse syndromes in the hands and wrists of chiropractors in South Africa as a result of their daily use of manual therapy techniques while at work. There are very few statistics available that disclose the nature and incidence of work related injuries. However those statistics that do exist suggest that hands on patient activities place physical therapists at greater risk of injury in comparison to other health care workers (Lunne et al., 2000). A study conducted by Bork et al.(1996) determined the prevalence of work-related musculoskeletal injuries sustained by physical therapists. Hand pain (29.6%) and back pain (45%) where the leading cause of pain in physical therapists (Bork et al., 1996.) Chiropractic and physiotherapy are both health care professions that specialize in the treatment of disorders pertaining to the neuro-musculo-skeletal system (Hunter, 2004). Physical therapists use manual therapy techniques as part of their daily working activities, so it can be assumed that chiropractors too will have a high prevalence of hand and wrist pain as they utilize similar therapeutic techniques to physical therapists. Cromie et al.(2000) evaluated the prevalence, severity, risks, and responses of disorders in physical therapists. He identified 4 categories of major risk factors commonly associated with workers musculo-skeletal disorders in physical therapists 1. Risk factors related to specific activities. 2. Postural risk factors. 3. Risk factors with regard to work load issues 4. Risk factors in regard of work capacity and health of the participant (Cromie et al., 2000). Physical risk factors found to be associated with neck, shoulder, or hand and wrist disorders in cross sectional studies are heavy lifting, monotonous work, static work postures, vibrations and repetitive jobs, and a high work pace (Alfredsson et al., 1999). Other factors that have been associated with musculoskeletal pain are higher age and female gender (de Zwart et al., 2001; Wahlstedt et al., 2001; Feveile et al., 2002). / M

This thesis investigates the implications of area-based regeneration for residents' health and well-being. The last three decades have seen significant investment in area-based initiatives in the UK to regenerate declining areas. However, there is a dearth of robust evidence on the impact that area regeneration practices have on health and health inequalities. This is particularly so in the case of the Scottish Area Regeneration Partnership (SARP) Programmes initiated in the mid-1990s, the evaluation of which was beset by a lack of baseline data and poor data collection generally. This study therefore seeks to address the lack of evidence by employing a rigorous mixed methods approach to evaluate the SARP programmes. Firstly, a quasi-experimental analysis of data from the Scottish Longitudinal Study (SLS) is undertaken. Comparator areas were identified using propensity score matching and a series of models was fitted to examine whether health outcomes of residents and migrants differed between regeneration areas and comparator areas. This is followed by a qualitative study exploring experiences of regeneration, carried out to provide insight into the results of the quasi-experiment. The findings provide no evidence that the programme had a positive impact on the health and well-being of SARP area residents relative to comparator area residents, and moreover, suggest that the programme may even have had a negative impact. Nor do they support the often stated hypothesis that those who move out of regeneration areas have done so because they have benefited from the programme and been replaced with residents who are likely to be more deprived. In addition, interviews with regeneration professionals and residents found that smaller initiatives overlapped with the SARPs, making it difficult to isolate the impacts of the programme under study. The conclusion reflects on the implications of these findings for the evaluation of public policy programmes.

Lung cancer is one of the most important causes of 'avoidable deaths' globally and is responsible for approximately 900,000 deaths per year. However, lung cancer rates tend to be higher for males than for females and the disease also varies geographically, as rates are far higher in developed countries compared to developing countries. Scotland has the highest rate of lung cancer of any country where lung cancer data is available. However, explaining the spatial distribution of this disease is difficult because lung cancer has a number of known causes that operate at a range of different spatial scales. This is further complicated by the lag time between the period of exposure to a risk factor and the date of diagnosis. This thesis examines the causes of lung cancer across Scotland, using lung cancer registrations for the period 1988 to 1991. Exploratory methods are presented for examining the geographical distribution of the disease in small areas using methods of age-standardisation and cluster detection to identify areas with unusual rates. Estimates of the key risk factors potentially associated with lung cancer are calculated for the same small areas. These include estimates of smoking behaviour, air pollution levels in 1971 and 1991, radon gas potential, coal mining activity, quarrying activity and area deprivation. The risk factors are incorporated into a set of regression models to examine which factors are significant in explaining lung cancer incidence. Finally, the residual values derived from the optimum model of lung cancer incidence in Scotland are examined to identify areas where lung cancer incidence is particularly high and low. This study revealed that there were marked geographical differences in lung cancer rates, with higher rates in the large urban areas, especially Glasgow, and also the more deprived areas of Scotland. Smoking was consistently significant in explaining lung cancer incidence for all cohorts, types of lung cancer and urban-rural areas. The estimated air pollution levels in 1971 were also found to be significant, but the 1991 estimates were not. Exposure to radon was only significant in explaining lung cancer in the younger age groups. However, the coal mining and quarrying variables did not independently influence the incidence of the disease. Area deprivation and measure of urbanness both had a significant effect on lung cancer incidence in Scotland that was independent of the key risk factors. The analysis of the residual values showed that, having controlled for the key risk factors, lung cancer incidence is higher than expected in rural rather than urban areas.

M.Sc.(Nanoscience) / The synthesis and application of gold nanoparticles (AuNPs) has been intensively studied worldwide. However, the toxicity of these nanoparticles is still a concern. We considered that various physiochemical methods used to synthesize AuNPs are energy driven, costly and require the use of harmful chemicals. Thus, this makes them not environmentally-friendly. The aim of this study was therefore to synthesize AuNPs via a greener route using Aspalathus linearis tea leaves. The AuNPs were used to coat eight commercial antifungal discs (i.e. amphotericin B, fluconazole, clotrimazole, econazole, flucytosine, ketoconazole, miconazole and nystatin) against four Aspergillus spp. for enhanced antifungal activity. The aqueous extract of A. linearis was characterized by high performance liquid chromatography and liquid chromatography–mass spectroscopy. The AuNPs were characterized using ultravioletvisible (UV-vis) spectroscopy, dynamic light scattering, nanoparticle tracking analysis, Fourier transforms infrared spectroscopy (FTIR), high-resolution transmission electron microscopy and X-ray diffraction. The toxicity of the synthesized AuNPs was studied by 3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay and xCELLigence test on HepG-2 cell lines and results revealed very little to no toxicity of the AuNPs. The pristine antifungal and AuNPs coated antifungal discs were characterized by FTIR, scanning electron microscopy (SEM) and antifungal activity performed using the disc diffusion method. A strong resonance peak was observed at 529 nm of the AuNPs measured using UV-vis spectroscopy. Average size of AuNPs was ~44±1 nm and demonstrated excellent in-vitro stability under various solutions (5% NaCl, phosphate buffered saline) at varying pH levels. The SEM images revealed that the AuNPs were attached onto the coated antifungal discs when compared with the pristine antifungal discs. Antifungal results indicated that AuNPs significantly (p<0.001) enhanced the antifungal activity of the coated antifungal discs against the tested fungi when compared to the pristine antifungal discs. The AuNPs coated econazole disc exhibited the greatest (broad spectrum) activity than other antifungal agents tested. In conclusion, A. linearis can be used as a reducing agent in the synthesis of stable AuNPs. Furthermore, the AuNPs coated antifungal discs demonstrated considerable antifungal activity over the pristine antifungal discs...

A research project submitted in partial fulfilment of the requirements for the degree of MA by coursework and Research Report in the field of Organisational Psychology in the Faculty of Humanities. University of the Witwatersrand, Johannesburg. March 2016 / There is international growing evidence to support the notion that indoor planters positively impact employees’ emotional states, personal health, work engagement as well as their overall perceptions of their work environment and ultimately impacting employee productivity. However this ground-breaking research has never been conducted within a South African Work Environment. Consequently the following study adopts a quasi-experimental study in order to investigate the impact that indoor plants may have on employee physical well-being, psychological well-being, work engagement and their overall perception of their work environment. Furthermore, the researcher aimed to assess whether the employees connectedness to nature influenced the impact the plants had on them, thus assessing how this covariate may impact the relationship between the absence and presence of plants and the above mentioned dependent variables. A Sample of 32 Global Service Management Centre (GSMC) employees from an internationally recognised organisation, Business Connexion, were assessed over a period of 12 weeks. The first assessment was conducted in the no plant condition, while the final assessment was conducted once the plants were installed in the whole office area. Additionally, SE Controls were positioned throughout the office area in order to measure the fluctuations of the air quality once the planters were installed. The results of a series of Wilcoxon Sign Rank Tests as well as Spearman’s Rank Order Correlations indicated no significant results; however upon closer evaluations of the individual scale items the researcher identified several statistically significant results that were unpacked and discussed. The readings from the SE Controls indicated either an improvement or stabalisation of the air quality variables that were being assessed in the current study. / GR2017

A research project submitted in partial fulfilment of the requirements for the degree of MA by coursework and Research Report in the field of Industrial Psychology in the Faculty of Humanities. University of the Witwatersrand, Johannesburg. February/May 2017 / Much evidence exists with regard to indoor plants and their positive effect on psychological perceptions as well as environmental air quality. However, this type of research has only ever been conducted once in a South African setting, which can be argued, is different to international contexts, in terms of climate and financial status. Indoor plants and their positive effects may have monumental effects on employees. This research assessed the presence of plants, on a sample of 34 employees at Discovery VitalityLife, consisting of Human Resources workers and call centre agents, on psychological perceptions (work engagement; psychological well-being; physical well-being and aesthetics) and on environmental factors (Total Volatile Organic Compounds; Benzene; Xylene; Carbon Dioxide (CO2); temperature and relative humidity). This research was conducted over a period of approximately three months whereby at Time 1 plants were absent and Time 2 plants were present. The same questionnaires were administered at both times. So too were Volatile Organic Compounds measured weekly and three measurement devices were installed in the workplace taking measurements of CO2, humidity, and indoor temperature every hour. The results found were that there were no statistically significant differences for the psychological perceptions from Time 1 to Time 2. This was concluded to be a result of the context in which this research took place. Total Volatile Organic Compounds, Benzene and relative humidity levels statistically significantly decreased at Time 2. Xylene levels statistically significantly increased at Time 2. There was no evidence to suggest statistically significant differences for CO2 and temperature from Time 1 to Time 2. / MT2018

A research report submitted to the Schools of Public Health and Social Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the award of the Degree of Masters of Arts in the Demography and Population Studies / Although life expectancy has increased in South Africa (RSA), compared with other middle-income countries, health status is poor most especially among the black majority. Coupled with this are the burdens of infectious and non-communicable diseases. RSA has also shown evidence of weak social cohesion through prevalent racial and gender discrimination, income inequalities, and violence. While previous studies on the health status of adults in RSA has only examined its association with other social determinants, the relationship of adult health status and social cohesion, unlike in developed countries, remains under researched in South Africa and other African countries. Using the collective efficacy theory by Sampson and colleagues (1997), this study adds the ‘African perspective’ to the ongoing debate about the health importance of social cohesion. It examined the relationship between social cohesion and the health status of adults in South Africa. The levels and patterns of health across social cohesion and other socio-demographic characteristics were also examined. DATA AND METHODS: Data was drawn from the 2012 South African Social Attitudes Survey, a survey implemented annually by the Human Sciences Research Council. Social cohesion was assessed by drawing from the five measurable items from the work of Sampson and colleagues (1997) which encompass trust, a sense of belonging, shared values and helpless in both cash and kind. These items were subjected to principal component factor analysis with Promax rotation. Cronbach’s alpha (α) for this scale is 0.84. Scores were divided into tertiles of low, medium and high social cohesion. A cumulative stepwise logistic regression model was fitted on a weighted sample of 22,605,550 adults in South Africa aged 18 years or older to examine the nexus between social cohesion and self-rated health status. Sub-group analysis examined if the observed relationship differed by race. The data was analysed using STATA software version 14. All model diagnostics showed that the model fits reasonably for the data. The interpretation of results was made using odds ratios (ORs), and a 95% confidence was used. RESULTS: More than half of adults (54%) in South Africa reported themselves to be in good health while only about 17% reported that they were in poor health. The percentage of adults reporting good health is higher among adults in the highest tertile of social cohesion (59%), compared to 53% among those in the lowest tertile. Controlling for other characteristics, regression analysis showed that adults in lowest tertile [OR:0.70, CI:0.516 - 0.965] and moderate tertile [OR:0.79, CI:0.589 - 1.055] of social cohesion were less likely to report moderate or good health compared to adults in the highest tertile of social cohesion, but the relationship was only statistically significant among adults in the lowest tertile of social cohesion. Sub-group analysis by race showed that among all the racial groups (excluding Indian or Asian adults), black African [OR:0.68, CI:0.472-0.989], coloured [OR:0.63, CI:0.305-1.309], and white [OR:0.67, CI:0.293 1.545] adults residing in the lowest tertile of social cohesion were less likely to be in moderate or good health compared to those in the highest tertile of social cohesion, but the relationship was only statistically significant among black Africans. CONCLUSION AND RECOMMENDATION: The findings from this study demonstrate that social cohesion among adults in South Africa, particularly among black Africans, is important for improvement in health. It is therefore important that the government of South Africa intensifies efforts aimed at increasing social cohesion among adults, particularly among black Africans. This could be achieved through public awareness on the health importance of social cohesion and the need for neighbours to share similar values, trust one another and be willing to help. This is especially important if significant progress is to be made in achieving the sustainable development goals to improve the health of adults in the country by 2030. / XL2018

Persistent, anthropogenic contaminants collectively known as endocrine-disrupting chemicals (EDCs), are considered to be potential threats to wildlife reproductive fitness (Wingfield, 2002). The modes by which EDCs act on the reproductive system, and establishment of steroid profiles in wildlife, are important areas of study. Two means of performing an endocrine snapshot profile from dolphin tissues (serum and urine) were tested on samples, comparing a novel high performance liquid chromatography method to newly-validated enzyme-linked immunoassays (ELISAs). Serum and urine samples were obtained from two marine parks, and from free-ranging dolphins in the Indian River Lagoon (IRL) and Charleston Harbor (CHS) systems. Relative binding affinities of steroids versus putative EDCs to steroid receptors were compared in dolphin reproductive tissues, obtained by the Georgia Aquarium's Dolphin Conservation Field Station (GADCFS) from strained bottlenose dolphins (four male, three female) during 2010 and 20ll.........I conclude that endocrine disruptors are tissue and receptor specific, and both legacy and emerging contaminants are of concern to dolphin stocks, particularly those facing other significant environmental stressors. / by Sharon M. Homer-Drummond. / Vita. / Thesis (Ph.D.)--Florida Atlantic University, 2012. / Includes bibliography. / Mode of access: World Wide Web. / System requirements: Adobe Reader.

While coffee culture has long since been positively associated with intellectual and working life, the health and safety of its primary stimulant, caffeine, has recently fallen under scrutiny by the FDA. This medical anthropology thesis provides a biocultural synthesis of caffeine culture, health effects, and biological variation in adverse effects related to pharmacodynamics and pharmacokinetics. Supporting evidence for variation in responses to caffeine was found through surveying 100 participants, investigating caffeine consumption levels, perceptions and health beliefs, adverse effects experienced, and medical encounters. Increased rates of adverse effects were found for students, pharmaceutical and over-the-counter drug users, and for participants reporting negative or ambivalent perceptions of caffeine, intolerance, or sensitivity to caffeine. Variation in rates of adverse effects suggests biocultural interactions account not only for patterns in pharmacological data, but are also clinically significant in constructing risk of caffeine intoxication. / Includes bibliography. / Thesis (M.A.)--Florida Atlantic University, 2014. / FAU Electronic Theses and Dissertations Collection

Obesity is associated with elevated levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and inflammatory regulator, however circulating FGF21 concentrations are elevated in obese individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight individuals, however the effect of acute aerobic exercise on plasma FGF21 response and the relationships with inflammation (IL-6 and TNF-α), insulin resistance, and energy expenditure in obese individuals is unknown. Following 30 minutes of treadmill running at 75% VO2max, plasma FGF21 response, as indicated by area-under-the-curve “with respect to increase” (AUCi) analyses, was attenuated in 12 obese compared to 12 normalweight subjects. Additionally, FGF21 AUCi positively correlated with glucose AUCi, total relative energy expenditure, and relative VO2max, suggesting that cardiorespiratory fitness levels may predict FGF21 response, contributing to the enhanced regulation of glucose and energy metabolism. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2014. / FAU Electronic Theses and Dissertations Collection