Thesis (Ph. D.)--University of Wisconsin--Madison, 1972. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

Thesis (M.A.)--University of North Carolina at Chapel Hill, 2004. / Includes bibliographical references (leaves 48-52).

Thesis (Ph. D.)--Michigan State University, 2005. / Includes bibliographical references (leaves 70-77). Also available online (PDF file) by a subscription to the set or by purchasing the individual file.

Thesis (Ph. D.)--Michigan State University, 2005. / Includes bibliographical references (leaves 70-77).

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1987. / Vita. Abstract. Includes bibliographies. Also available via the Internet.

Thesis (Ph. D.)--University of Washington, 1986. / Vita. Bibliography: leaves [153]-162.

Submitted in fulfilment of the Master’s Degree in Clinical Technology, Durban University of Technology, 2012. / The sirolimus-eluting stent (Cypher) was the first approved drug- eluting stent by the Food and Drug Administration in April 2003. This is a stent that is based on a bare-metal stent and is coated with a layer of polymer incorporating sirolimus and releasing it by diffusion. Drug-eluting stents reduced risk of restenosis and repeat revascularization as compared with bare-metal stents. Clinical data has raised concerns that drug-eluting stents are associated with late untoward events. Objectives: The objective of this study was to test the hypothesis that stenting is safe and effective treatment for coronary artery disease. Methods and Results: Sirolimus-eluting stenting was performed in 30 patients with 34 coronary lesions. Detailed clinical follow-up data was collected by personal interview or telephone contact at 1, 6, 12 and 24 months. Patients were followed for 2 years for the occurrence of angina and cardiovascular events namely death, myocardial infarction, stent thrombosis and target lesion revascularization. The mean age of the cohort was 62.33±10.99 years; 83 percent were male, 6 percent were diabetic, 53 percent had hypertension. In spite of the overall patient and lesion complexity there were no incidences of major adverse cardiac events and all patients remained angina free out to two years. Dual antiplatelet therapy with aspirin and plavix varied from at least four weeks to one year. One patient had a bleeding event. Conclusions: Treatment of lesions with sirolimus-eluting stents is associated with a sustained clinical benefit two years after device implantation.

Made available in DSpace on 2014-06-11T19:23:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-23Bitstream added on 2014-06-13T18:12:12Z : No. of bitstreams: 1 souza_dsb_me_botfm.pdf: 638871 bytes, checksum: 9fa2900e6fc35bf88e820c9d2e7ffb22 (MD5) / O objetivo geral deste estudo foi avaliar a presença, a sintomatologia predominante e as fases do estresse, identificar estratégias de enfrentamento de problemas utilizadas por mães de crianças cardiopatas submetidas a cirurgia cardíaca, e os objetivos específicos associar as variáveis tais como estratégia de enfrentamento e cardiopatia, fase de estresse e cardiopatia, fase de estresse e faixa etária da mãe, estratégia de enfrentamento e idade da mãe, fase de estresse e estratégia de enfrentamento, classe sócio-econômica e estratégia de enfrentamento. A amostra da pesquisa constituiu-se de 60 mães de crianças cardiopatas. Foram incluídas no estudo somente as mães biológicas, as quais vivenciavam a experiência da primeira cirurgia cardíaca do filho logo após a revelação do diagnóstico. Foi um estudo epidemiológico de prevalência do tipo transversal. Os resultados indicaram que a maioria das mães apresentou estresse na fase de resistênci , fase caracterizada por demasiado estresse e vulnerabilidade a doenças, com predominância de sintomas psicológicos, a estratégia de enfrentamento prioritária foi a busca de práticas religiosas. Para a análise estatística foi utilizado o teste Qui-quadrado, que mostrou não haver associação entre as variáveis tipo de cardiopatia com as estratégias de enfrentamento P= 0,840, cardiopatia com a fase de estresse P= 0,675, fase de estresse com estratégia de enfrentamento P= 0,375, fase de estresse com faixa etária, estratégia de enfrentamento com faixa etária e classe social com estratégia de enfrentamento P= 0,444, pois os valores de P foram > 0,05. Com base nos resultados obtidos concluiu-se que é necessário uma intervenção profissional com o objetivo de acolher, orientar e disponibilizar recursos de auxílio as mães desde o diagnóstico à alta hospitalar da criança para favorecer a um enfrentamento e adaptação... / Study general objectives: to assess stress and coping in mothers of children with congenital heart disease who had undergone surgery; and specifics objectives to associate coping style, stress, mothers age, heart disease and social class. Methods: Sixty mothers whose children had undergone surgery for congenital heart disease filled the Lipp Stress Symptoms Inventory for Adults, and the Ways of Coping Scale. Results: most mothers were in the resistance stage of stress. Psychological symptoms of stress were predominant and the most used coping strategy was religion. Chi-square test showed no association (p≤0.05) between heart disease and coping style (p = 0,840), heart disease and stress stage (p = 0,675), stress stage and coping (p = 0,375), stress and age, coping and age and social class and age and social class and coping (P = 0,444). The presence of and age stress in the resistance stage in most participants indicates the need for professional intervention from diagnosis until the discharge after surgery, to favor positive coping strategies and a better quality of life for mother and child.

M.Cur. (Intensive General Nursing) / The incidence of coronary heart disease is still rising due to man's stressful way of life. Angioplasty is a relatively new procedure used to dilate coronary arteries which have been narrowed by sclerosis. This is seen as the 'instant solution' for a select group of patients with coronary artery sclerosis. It fits in well in the fast paced society. Angioplasty is painful and causes anxiety as the patient is awake during the whole procedure. The goal of the study is to determine the patient's experience during angioplasty and to set guidelines for nurses for the preparation of other patients for angioplasty. The Phenomenological method of interviewing was used for data-collection. Interviews were conducted with 9 participants who had had their first experience of angioplasty. Data was subjected to Phenomenological analysis and verified with suitable literature. The conclusions that were reached were used to set guidelines and make suggestions for the counselling of patients for angioplasty.

Coronary Heart Disease (CETO) is one of the most common causes of mortality in industrialised societies, and it has been demonstrated elsewhere that shift workers have an increased risk of developing CHD compared to day-workers. One possible explanation for this increased risk is that a shift worker may show inappropriate postprandial responses to a night-time meal, when their biological clock is not adapted to the night shift. This could lead to an elevation in the circulating levels of certain hormones and metabolites, such as triacylglycerol (TAG) and insulin, which are known to be risk factors for CHD. This thesis investigated the relationships between meal times and postprandial hormone and metabolic responses in simulated and real-life shift-workers. The work is presented as three major clinical trials. In the first of these, a combination of timed bright light and darkness/sleep was used to induce a gradual 9-hour phase advance in 12 healthy subjects, who then underwent a rapid 9-hour phase delay. Three meal study days were arranged, to occur during the baseline condition, immediately after the rapid phase delay, so that the subjects effectively had "simulated jet lag", and two days later. Blood parameters measured included plasma glucose, insulin, proinsulin, C-peptide, non-esterified fatty acids (NEFA), TAG and glucose- dependent insulinotropic polypeptide (GIP). Substantial differences in plasma TAG and NEFA were observed in the postprandial responses when the subjects consumed an identical meal immediately after the rapid phase delay, compared with during the baseline conditions. Two days after the rapid phase delay, subjects showed inteimediate hormone and metabolite levels, suggesting that the biological clock had a major effect on these postprandial responses. In the second study, day and night-time postprandial responses were compared in a simulated shift work environment, and the effectiveness of a number of potentially beneficial procedures was investigated. These included alterations to the content of the meal consiraied prior to the night shift, bright light exposure during the night shift, and a daytime rest period prior to the night shift. As in the first study, significant differences were seen in a number of hormones and metabolites on the night shift. compared with during the day. The content of the previous meal, bright light exposure and a daytime rest period prior to the night shift all had significant effects on the night-time postprandial responses. The most exciting discovery made was that a single 8-hour night-time bright light exposure significantly lowered the TAG postprandial responses on the simulated night shift. As all the work conducted up until this point had utilised simulated conditions, it was important to illustrate that similar differences in postprandial responses at night-time could be demonstrated in "real-life shift workers". Thus, nine midwives were recruited from the Royal Surrey County Hospital, and studied on four occasions. This allowed comparison of postprandial responses on both day and night shifts, and also allowed further investigation of the effect of altering the content of the previous meal. Significant differences were again found in a number of blood parameters when the night-time and day-time responses to the test meal were compared, with the most striking being a delayed NEFA rise on the night shift, compared with during the day. In conclusion, this series of studies have illustrated that the human body responds differently to a meal consumed at night-time, compared with during the day, both in a simulated and a real-life environment. This results in variations in the levels of a number of known CHD risk factors, and may be linked with the elevated CHD risk reported in shift workers. Alteration to the meal prior to the night shift, exposure to bright light during the night shift, and instituting a rest period prior to the night shift, were all shown to be potentially beneficial in reducing the variation between day and night-time responses.