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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

A novel preparation method for porous hemi-spherical bio-polymeric microparticles

Naidoo, Kersch 11 July 2011 (has links)
A modified oil-in-water emulsion process was developed to produce novel microporous hemi-spherical polycaprolactone (PCL) microparticles called “hemi-shells”. Through the addition of a porogen such as sodium bicarbonate into the PCL-dichloromethane oil phase and emulsification in an acidic polyvinyl alcohol aqueous phase, microporous hemi-shells formed as dichloromethane evaporated. Carbon dioxide gas evolution from the porogen reaction with the acidic aqueous phase created particles with an externally microporous shell and a large internal cavity. The hemi-shells were characterized by various methods, including scanning electron microscopy and optical microscopy which were specifically used to quantify the hemi-shell yield. The final number-average particle yield of the optimised manufacturing method for particle manufacture in the 50-200 micron size range was 84%. The number-average hemi-shell yield in the same size range was 41%. These novel microparticles have potential applications in tissue engineering and drug delivery / Dissertation (MEng)--University of Pretoria, 2011. / Chemical Engineering / unrestricted

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