Philosophiae Doctor - PhD / The aim of this study was to prospectively, evaluate the effectiveness of an individually designed home-based physical activity programme in combination with massage therapy, on motor and cognitive development in children infected with HIV. This study used a randomized controlled trial design. One hundred and twenty-eight infants and toddlers (children) were recruited between March 2010 and September 2010 and randomly allocated to receive either an individually designed home-based physical activity programme in combination with massage therapy or standard treatment and massage on a 1:1 ratio. Motor and cognitive development was measured using the Bayley Scales of Infant Development third edition (Bayley-III)