published_or_final_version / Statistics / Doctoral / Doctor of Philosophy

No description available.

No description available.

No description available.

Thesis (Ph.D.) -- University of Western Sydney, 2004. / "A thesis submitted to the University of Western Sydney in fulfillment of the requirements for the degree of Doctor of Philosophy" Includes bibliography.

Šis reljefas „Arklių lenktynės“ yra skulptoriaus Gedimino Jokūbonio diplominis darbas, sukurtas 1952 m. Dėl netinkamų laikymo sąlygų lauke, gipsinis reljefas buvo blogos būklės. Restauravimo metu darbas nuvalytas, antiseptikuotas, suklijuotas, pagamintas tvirtas metalinis rėmas, atliktas antikorozinis metalo armatūros apdorojimas, atkurtos netektys, sutankintas poringas gipso paviršius. / This relief „Horse race“ is a graduation work by Gediminas Jokūbonis made in 1952. Due to unsuited outside storing conditions the gypsum relief was in bad shape. The artwork was cleaned, antisepted, glued; a strong metal frame added; anti corrosive treatment applied to the metal armature; loses reconstructed; the porous gypsum surface densened.

This thesis is the first substantive analysis of unregistered proprietary horse racing (or pony racing, as it was popularly known) in Sydney, an extremely popular form of the sport conducted weekly or more frequently between 1888 and 1942. However, a number of researchers working on its periphery have contributed commentary and judgements to a discourse on it that has existed since the establishment of the Sydney Turf Club (STC) in 1943. Their writings have created an orthodox view of the sport that suggests inter alia it was a cultural expression of a ‘needy and greedy’ element of the working class and that its constituency was excluded from that of the racing of the Establishment, conducted by the Australian Jockey Club (AJC). This orthodoxy also holds unregistered racing was subject to endemic corruption, haphazardly conducted, inexpensive to attend, provided poor money and was in general a burlesque of AJC racing. The thesis engages this discourse and tests the tenets of the orthodoxy through examination or re-examination of relevant primary sources, including parliamentary papers, contemporary newspapers and journals, race books and other documents, administrative records, photographs, and the memoirs and transcripts of oral history provided by human participants. / Doctor of Philosophy (PhD)

published_or_final_version / Sociology / Master / Master of Philosophy

No description available.

Drug metabolism is a specialised subset of xenobiotic metabolism, pertaining to the breakdown and elimination of pharmaceutical drugs. The enzymes involved in these pathways are the cytochrome P450 family of isozymes. Metabolism is an important factor in determining the pharmacological effects of drugs. The main aim of this study was to develop a system whereby the major metabolites of drugs can be produced in vitro. An in vitro system was developed and optimised using commercially prepared microsomes from rat liver and coumarin (by monitoring its conversion to 7-hydroxycoumarin) as a model. The optimum running conditions for the incubations were 50 μM coumarin, 50 μg protein/ml microsomes, 1 mM NADP⁺, 5 mM G6P and 1U/ml G6PDH incubated for 30 minutes at 38℃. The HPLC method for the detection of coumarin and 7-hydroxycoumarin was also validated with respect to linearity, reproducibility, precision, accuracy and lower limits of detection and quantification. The system developed was then tested using microsomes prepared from fresh bovine liver on these ten drugs of interest in doping control in horse racing: diazepam, nordiazepam, oxazepam, promazine, acepromazine, chlorpromazine, morphine, codeine, etoricoxib and lumiracoxib. The bovine liver microsomes were prepared using differential centrifugation and had activity on a par with the commercial preparations. This in vitro system metabolised the drugs and produced both phase I and II metabolites, similar to those observed in humans and horses in vivo. For example, the major metabolites of the benzodiazepine drug, diazepam, nordiazepam, temazepam and oxazepam as well as the glucuronidated phase II products were all found after incubations with the bovine liver microsomes. The metabolism of the drugs was also investigated in silico using the computational procedure, MetaSite. MetaSite was able to successfully predict known metabolites for most of the drugs studied. Differences were observed from the in vitro incubations and this is most likely due to MetaSite using only human cytochrome P450s for analysis.