Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This present study is about the phytotherapic effects of the hydroalchoholic extracted from the Hyptis fruticosa leaves. Typical plant from the northeast of Brazil used as an aromatyzer and discongestyzer. Probably, de Araújo et. al., 1974, were the first ones to study and discribe the studies of the metanolic extracts from the roots of this plant, that contains antimicroorganism and antineoplasic activity. Pain, insomnia and epilepsy are disturbs that attack people in our society, specially pain, causing personal and socialeconomic problems. The main objective of this study is to describe partialy the effects of the hydroalchoholic extracted from the Hyptis fruticosa Salzm. (ex) Benth. leaves in the nervours central system of mice. Having as specifics objectives: to determinate the acute toxicity (DL50); to evidence the anticonvulsant and sedative/hypnotic effects; to mensure the antinociceptive effects in mice. This is an experimental search using acute toxicity test in the doses 1, 2, 3, 4 and 5 grams; pentylenetetrazole-induced convulsion, 60mg/Kg i.p.; pentobarbital-induced sleep, 60mg/Kg i.p.; writhing-induced by acetic acid 6% and tail-flick test. The animals used were the swiss type mice. The data obtained were analysed by ANOVA, the p<0,05 values were considered significant. According to the results, it was demonstrated that the estract has low toxicity; the pentylenetetrazole-induced convulsion showed a latence low increase for the beginning of the 1ª convulsion and the death; The ANOVA showed significance with p<0,0001 at the return of the righting reflex on the sleep-induced by tiopental, writhing-induced by acetic acid and thermal nociceptive stimulation. Is possible to conclude, this way, that the hydroalchoholic extract of Hyptis fruticosa leaves has antinociceptive effects on the central and peripheral nervous system and low sedative, however, without any anticonvulsant activity. For more informations, studies with more details is suggested. / O presente trabalho trata de um estudo sobre os efeitos fitoterápicos do extrato hidroalcoólico das folhas da Hyptis fruticosa. Planta típica do nordeste do Brasil utilizada como aromatizante e descongestionante, provavelmente, de Araújo e colaboradores, 1974, foram os primeiros a relatar estudo dos extratos metanólicos extraídos das raízes da planta, com atividade antimicrobiana e antineoplásica. A dor, a insônia e a epilepsia são transtornos que afligem as pessoas na sociedade, principalmente a dor, causando prejuízos pessoais e socioeconômicos. O objetivo principal deste estudo é caracterizar parcialmente os efeitos do extrato hidroalcoólico das folhas da Hyptis fruticosa Salzm. (ex) Benth. no sistema nervoso central de camundongos; tendo como objetivos específicos determinar a toxicidade aguda (DL50); evidenciar efeito convulsivante e sedativo/hipnótico; e mensurar efeitos antinociceptivos em camundongos. Essa pesquisa é do tipo experimental utilizando os teste de toxicidade aguda nas doses 1, 2, 3, 4 e 5 gramas; os testes de convulsão induzida por pentilenotetrazol, 60mg/Kg i.p., sono induzido por tiopental sódico, 60mg/Kg i.p., contorção abdominal induzida por ácido acético a 6% e teste Tail-flick . Os animais utilizados foram camundongos do tipo Swiss. Os dados obtidos foram analisados pela ANOVA, valores de p<0,05 foram considerados significativos. Em relação aos resultados foi demonstrado que o extrato é de baixa toxicidade. No teste de convulsão induzida por pentilenotetrazol houve pequeno aumento na latência para o início da 1ª convulsão e para a morte. Em relação a ANOVA nos testes quanto a recuperação do reflexo de endireitamento no sono induzido por tiopental, contorção abdominal por ácido acético e nocicepção térmica, os mesmos revelaram significância com p<0,0001. Conclui-se desta forma que o extrato das folhas da Hyptis fruticosa Salzm. (ex) Benth. apresenta efeito antinociceptivo no sistema nervoso central e Caracterização Parcial dos Efeitos do Extrato Hidroalcoólico... 9 periférico e pequena sedação, porém, sem nenhuma atividade anticonvulsivante. Sugere-se estudos mais detalhados para maiores esclarecimentos.

The Creation and Manifestation of Reality-theory was developed for this study. This theory provides an answer to why high functioning people experience problems at work, develop relationship problems, and other dysfunctions that occur in their lives. It provides an explanation as to why this happens: at a certain point in our existence a critical incident (or Initial Sensitising Event) or a series of repeated incidents is perceived by the person as traumatic. During this time of high emotion the child forms a subconscious conclusion, followed by a subconscious decision. The Hypnotic Blueprint is an accumulation of all the different subconscious conclusions and decisions formed over time at a time of intense emotionality, during which the psyche feared for its survival, repressed, gated and banished into the borders of the person's subconscious mind. Numerous other incidents occur through life that reinforce and bolster the original Hypnotic Blueprint. Simultaneously, conflicting ego-states are formed, attempting to balance the state of disequilibrium. Later in life, the original Blueprint is triggered, through the Symptom Activating Event, at a sub-conscious level and starts to operate in the person's life, attracting the circumstances and people who best replay or re-enact the original trauma on a symbolic level. This pattern will be recreated in the person's life, and will most often be the reason why the person enters therapy, or the presenting problem. Life acts as a mirror of the inner world or the psyche of the person. The inner world is mirrored by the other world, or reality. By changing our inner reality, we impact or transform our outer reality. To complete the Creation and Manifestation of Reality-theory, the Imago Developmental Stages identified by Harville Hendrix, were integrated, namely Attachment, Exploration, Identity and Competence. The therapeutic modality suggested is de-hypnotising. The study does not intend to measure the success of the therapy, but rather to establish and test the validity of the Creation and Manifestation of Reality-theory on case studies, using the Life History approach. / Educational Studies / DED(PSYCHOLOGY OF EDUCATION)

The Creation and Manifestation of Reality-theory was developed for this study. This theory provides an answer to why high functioning people experience problems at work, develop relationship problems, and other dysfunctions that occur in their lives. It provides an explanation as to why this happens: at a certain point in our existence a critical incident (or Initial Sensitising Event) or a series of repeated incidents is perceived by the person as traumatic. During this time of high emotion the child forms a subconscious conclusion, followed by a subconscious decision. The Hypnotic Blueprint is an accumulation of all the different subconscious conclusions and decisions formed over time at a time of intense emotionality, during which the psyche feared for its survival, repressed, gated and banished into the borders of the person's subconscious mind. Numerous other incidents occur through life that reinforce and bolster the original Hypnotic Blueprint. Simultaneously, conflicting ego-states are formed, attempting to balance the state of disequilibrium. Later in life, the original Blueprint is triggered, through the Symptom Activating Event, at a sub-conscious level and starts to operate in the person's life, attracting the circumstances and people who best replay or re-enact the original trauma on a symbolic level. This pattern will be recreated in the person's life, and will most often be the reason why the person enters therapy, or the presenting problem. Life acts as a mirror of the inner world or the psyche of the person. The inner world is mirrored by the other world, or reality. By changing our inner reality, we impact or transform our outer reality. To complete the Creation and Manifestation of Reality-theory, the Imago Developmental Stages identified by Harville Hendrix, were integrated, namely Attachment, Exploration, Identity and Competence. The therapeutic modality suggested is de-hypnotising. The study does not intend to measure the success of the therapy, but rather to establish and test the validity of the Creation and Manifestation of Reality-theory on case studies, using the Life History approach. / Educational Studies / DED(PSYCHOLOGY OF EDUCATION)