Global ETD Search

191	Elucidation of Mechanisms Underlying Metastatic Melanoma Immune Escape via Suppression of Major Histocompatibility Complex (MHC) II through Dysregulation of the JAK/STAT Pathway Osborn, Jodi 11 May 2015 (has links) Transcriptional activation of Major Histocompatability Complex (MHC) I and II molecules by the cytokine interferon gamma (IFN-g) is a key step in cell-mediated immunity against pathogens and tumors. Following IFN-g induction, JAK/STAT signaling triggers activation of MHC genes. Recent evidence suggests suppression of MHC I and II expression on multiple tumor types plays important roles in tumor immunoevasion. One such tumor is malignant melanoma, the leading cause of skin cancer related deaths. Despite awareness of MHC expression defects, the molecular mechanisms by which melanoma cells suppress MHC and escape from immune-mediated destruction remain unknown. Here we analyze dysregulation of the JAK/STAT pathway and its role in suppression of MHC II in melanoma cell lines at the Radial Growth Phase (RGP), the Vertical Growth Phase (VGP) and the Metastatic Phase (MET). RGP and VGP cells express both MHC II and the MHC master regulator, the Class II Transactivator (CIITA). MET cells lack not only MHC II and CIITA, but also both STAT 1 and the STAT 1 coactivator, the Interferon Response Factor (IRF) 1. Our studies have implicated that the suppression of MHCII on the cell surface of metastatic melanoma is due to silencing at the level of STAT1 transcription. Furthermore, we determined that silencing of STAT1 is, in part, due to hemi-methylation of the STAT1 promoter. melanoma STAT1 MHC II immunosurveillance
192	A policy of neglect : British diplomacy towards French Indo-China, 1943-1945 Hutton, Claude January 1995 (has links) No description available. 900 World War II; Vietnam
193	Direct digital control of a steam-jacketed kettle Montilla, Victor Leon. January 1985 (has links) Thesis (M.S.)--Ohio University, November, 1985. / Title from PDF t.p. Steam-jackets. Apple II (Computer)
194	Sympathetic mechanisms of salt-sensitive hypertension King, Andrew J. January 2008 (has links) Thesis (Ph.D.)--Michigan State University. Dept. of Pharmacology and Toxicology, 2008. / Title from PDF t.p. (viewed on Mar. 30, 2009) Includes bibliographical references (p.177-201). Also issued in print.
195	Kriegsgefangenschaft in Großbritannien : Deutsche Soldaten des Zweiten Weltkriegs in britischem Gewahrsam Held, Renate January 2008 (has links) Zugl.: Bochum, Univ., Diss., 2005
196	Dissertatio Philologica De Lotionibus Et Balneis Graecorum / Kühn, Joachim. Scherz, Johann Georg. Unknown Date (has links) Schlüsselseiten aus dem Exemplar der BSB München: 4 Diss. 608.
197	Disputatio Metaphysica, De Vero / Faustius, Johannes. Geitz-Koflerin, Maria Polyxena. Schmoll, Wolffgangus Matthaeus. Unknown Date (has links) Schlüsselseiten aus dem Exemplar der FB Gotha: Diss.phil 8° 36 (48).
198	De Expectativa : Disputatio Inauguralis / Schatz, Johannes Henricus. January 1654 (has links) Univ., Jur. Disp.--Straßburg, 1654. / Fingerprint nach Ex. der ULB Halle. Vorlageform des Erscheinungsvermerks: Argentorati, Typis Friderici Spoor. M. DC. LIV.
199	Rôle et mécanismes d'action du récepteur AT2 de l'angiotensine II dans la différentiation neurale Gendron, Louis. January 2003 (has links) Thèses (Ph.D.)--Université de Sherbrooke (Canada), 2003. / Titre de l'écran-titre (visionné le 20 juin 2006). Publié aussi en version papier.
200	A comparison of three non-extraction treatment modalities for the correction of Class II malocclusion a thesis submitted in partial fulfillment ... for the degree of Master of Science in Orthodontics ... / Burkhardt, Donald R. January 2000 (has links) Thesis (M.S.)--University of Michigan, 2000. / Includes bibliographical references.

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