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Characterization of steroid sulfatase in human and mouse tissues and in the mouse MC3T3-E1 pre-osteoblastic cell lineDiFrancesca, Heidi M. January 2007 (has links) (PDF)
Thesis (Ph.D.)--Duquesne University, 2007. / Title from document title page. Abstract included in electronic submission form. Includes bibliographical references (p. 136-146).
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Immunohistochemical study of marmoset periodontal ligament microvasculature : a confocal laser scanning microscopic study /Ashworth, Jonathan F. January 1999 (has links) (PDF)
Thesis (M.D.S.) -- University of Adelaide, Dept. of Dentistry, 1999. / Bibliography: leaves 110-120.
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The demonstration of estrogen receptors in various tumours a study using immunohistochemistry and in situ hybridisation /Henwood, Anthony F. January 2004 (has links)
Thesis (M.Sc.)--University of Adelaide, Dept. of Anatomical Sciences, 2005? / Title from title page of source document; viewed July 19 2005. Bibliography: p. 91-107 of source document. Also available in print and CD-ROM forms.
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Corticotectal and corticocortical pathways underlying sound localization in the cat /Mellott, Jeffrey Garrett, January 2008 (has links)
Thesis (Ph.D.)--University of Texas at Dallas, 2008. / Includes vita. Includes bibliographical references (leaves 194-202)
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Studies on oral immune reactions in the genetically mercury-sensitive BN rat and in the hyperplastic BN=(BNxLEW) graft-versus-host diseasePeszkowski, Michael J. January 1996 (has links)
Thesis (doctoral)--Lunds Universitet, Malmö, 1996. / Added t.p. with thesis statement inserted. Includes bibliographical references.
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Studies on oral immune reactions in the genetically mercury-sensitive BN rat and in the hyperplastic BN=(BNxLEW) graft-versus-host disease Michael J. Peszkowski.Peszkowski, Michael J. January 1996 (has links)
Thesis (doctoral)--Lunds Universitet, Malmö, 1996. / Added t.p. with thesis statement inserted. Includes bibliographical references.
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Immunohistochemical analysis of Paks expression in ovarian cancer /Woo, Wing-shuen, Nina. January 2006 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2006.
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Expressão dos fatores de crescimento obtidos do plasma rico em plaquetas, no tratamento de fraturas experimentais do radio de cãesSouza, Talita Floering Brêda [UNESP] 22 February 2010 (has links) (PDF)
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souza_tfb_me_araca.pdf: 990469 bytes, checksum: 2edda3c74283bbc14ffbed941509caad (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Fundação para o Desenvolvimento da UNESP (FUNDUNESP) / O objetivo deste trabalho foi o de avaliar a cicatrização óssea de fraturas experimentais do radio de cães, tratadas ou não com o PRP autógeno, por meio de estudos radiográfico, densitométrico e histológico; bem como avaliar a expressão dos fatores de crescimento do PRP. Foram utilizados 21 cães inicialmente agrupados de acordo com o tempo de colheita de biopsia: aos sete dias (n=10) ou 60 dias (n=11) que foram alocados aleatoriamente em dois grupos experimentais: o grupo controle (G-controle, n=11) e o grupo PRP (G-PRP, n=10). Todos os animais foram submetidos à osteotomia e osteossíntese (fixador esquelético externo) do rádio direito, gerando-se um “gap” de 2,0mm, que foi preenchido ou não com PRP. Os estudos radiográficos e densitométricos foram realizados no pós-operatório imediato e até 60 dias de pós-operatório. As avaliações histológicas e imunoistoquímicas foram realizadas aos sete e 60 dias. Os dados encontrados foram tratados estatisticamente (p<0,05). Houve diferença significativa nas avaliações radiográficas e densitométricas entre os grupos. A avaliação histológica evidenciou uma cicatrização óssea mais avançada aos 60 dias no G-PRP e união óssea tardia no G-controle. Houve imunomarcação intensa do PDGF-B e TGF-β no G-PRP aos sete e 60 dias de pós-operatório. Conclui-se, que o PRP pode ser utilizado como terapia adjuvante, pois promoveu melhor cicatrização óssea em fraturas experimentais (“gap” de 2,0mm) do radio de cães tratadas com fixador esquelético externo. Ainda houve maior expressão do PDGF-B e TGF-β nos períodos, precoce e tardio, dos animais tratados com PRP / The present article aimed to assess bone healing of experimental radial fractures, treated or not with autologous PRP, by means of radiographic, densitometric and histological studies and evaluate the expression of growth factors in PRP. Were used 21 dogs initially grouped according to the time of biopsy collection: seven days (n = 10) or 60 days (n = 11) were randomly assigned to two groups: the control group (G-control, n = 11) and the PRP group (G-PRP, n = 10). All animals underwent osteotomy and fixation (external skeletal fixation) of the right radius, generating a gap of 2.0 mm, which was filled or not with PRP. Radiographic and densitometry studies were performed in the immediate postoperative period and to 60 days after the surgery. The histological and immunohistochemical evaluations were performed at seven and 60 days. The data were treated statistically (p <0.05). There were significant differences in densitometric and radiographic evaluations between the groups. Histological evaluation showed a more advanced bone healing at 60 days in G-PRP and bone union late in the G-control. There was intense expression of PDGF-B and TGF-β in G-PRP from seven to 60 days postoperatively. It is concluded that the PRP can be used as adjuvant therapy, because it provided better bone healing in experimental fractures (gap of 2.0 mm) radius of dogs treated with external skeletal fixation. Although there was a higher expression of PDGF-B and TGF-β in periods, early and late, the animals treated with PRP
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Avaliação do perfil de citoqueratinas e marcadores de proliferação celular em lesões odontogenicas : queratocisto odontogenico, cisto odontogenico ortoqueratinizado e fibroma odontogenico central / Avaliation of cytokeratin profile and celular proliferation markers in odontogenic lesions : odontogenic keratocyst, odontogenic orthokeratinized cyst and central odontogenic fibromaMartinez Mata, Guillermo 14 December 2007 (has links)
Orientador: Oslei Paes de Almeida / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-11T22:55:27Z (GMT). No. of bitstreams: 1
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Previous issue date: 2007 / Resumo: A região bucomaxilofacial é freqüentemente afetada por lesões císticas e tumorais que apresentam características clínicas e histológicas heterogêneas cuja origem está associada a diversos estágios da odontogênese. Entre as lesões císticas mais freqüentes, temos o queratocisto odontogênico (QO), enquanto o cisto odontogênico ortoqueratinizado (COO) é uma lesão rara. O QO apresenta índices de prevalência e recorrência elevados, sendo a terceira lesão cística mais comum na região orofacial, depois dos cistos radicular e dentígero, podendo estar associada à síndrome de Gorlin (QOSG). O fibroma odontogênico central (FOC) é um tumor odontogênico pouco freqüente, com 72 casos relatados na literatura, que afeta mais comumente a região mandibular de mulheres na terceira década da vida. O objetivo deste trabalho foi analisar as características clínicas, radiográficas, histopatológicas e perfil de marcadores de imunohistoquímica em 66 casos de QO solitários, 26 casos de QOSG, oito casos de COO e 10 casos de FOC. As lesões císticas odontogênicas afetaram em 51% dos casos homens e 49% mulheres. A marcação imunohistoquímica do epitélio mostrou positividade para Ck AE1/AE3, Ck 5, Ck 10, Ck 14 e Ck 19 com diferentes intensidades. A expressão de Bcl-2 foi estatísticamente significante maior para QOSG e QO quando comparados com COO. FOC apresentou-se mais comumente no gênero masculino, correspondendo a 70% dos casos, e afetou predominantemente as regiões posteriores da mandíbula (60%). Dois casos de FOC apresentaram-se como lesões híbridas, associados à lesão central de células gigantes (FOC/LCG). Em todos os casos de FOC o epitélio foi imunoreativo para Ck AE1/AE3, Ck 5, Ck 14 e Ck 19. O estroma de FOC foi positivo apenas para vimentina. As citoqueratinas 1, 7, 8 e 18 assim como HHF35, desmina e proteína S-100 foram negativos. A expressão de Bcl-2 nos FOC foi baixa, menor que 1%. Em conclusão QO, QOSG e COO expressaram perfil semelhante de Ck, mas com padrão distinto para Ck5 e Ck14. A expressão de Bcl-2 foi significantemente mais intensa nos QO e QOSG em relação ao COO. O perfil de expressão nas ilhas epiteliais do FOC para citoqueratinas foram semelhante aos QO, mas a expressão de Bcl-2 foi nula nos casos de FOC, o que pode estar relacionado com a menor taxa de recidiva destas lesões odontogênicas. / Abstract: Jaw bones are frequently affected by tumoral and cystic lesions which present heterogeneus clinical and pathological features associated with diverse stages of odontogenesis. These lesions include odontogenic keratocyst (OK) and rarely odontogenic orthokeratinized cyst (OOC). OK presents high recurrence and prevalence index, being the third lesion affecting the jaw bones, preceded only for radicular and dentigerous cyst; could be associated to Gorlin syndrome. Central odontogenic fibroma (COF) is a rare odontogenic tumor, with only 72 cases reported in the English literature, and is more prevalent in the posterior mandibular region of females in the third decade of life. The purpose of this work was to analyze the clinical, radiographic, histologic and immunohistochemistry profile of 66 cases of OK, 26 cases of OKGS, 26 cases of OOC and 10 cases of COF. Cystic lesions were more prevalent in males (51%) than in females (49%). Epithelial tissue of OK was reactive for Ck AE1/AE3, Ck5, Ck10, Ck14 and Ck19. The Bcl-2 and p53 expression was statistically significant for OK and OKGS when compared with OCC. COF was more common in males (70%) than in females (30%), and in the posterior mandibular regions (60%). Two cases were classified as "hybrid lesions" (COF and CGL). Epithelium of COF was reactive for Ck AE1/AE3, Ck5, Ck14 and Ck19. Stromal cells of FOC were positive for vimentin and negative for HHF-35, desmin and S-100 protein. Bcl-2 expression was negative. In conclusion, OK, OKGS and OOC have a similar immunohistochemical profile, although Ck5 and Ck14 present different pattern of expression among OK, OKGS and OOC. Bcl-2 index for OK and OKGS was higher than that of OCC. Epithelial nests of COF were positives for Ck's similarly to OK, OKGS and OOC. The index expression of Bcl-2 in COF was low when compared with that of cystic lesions, and could be related with the low index of recurrence of this tumor. / Doutorado / Patologia / Doutor em Estomatopatologia
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Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancyLockett, Nikki Nikkia 11 December 2009 (has links)
Mother-to-child transmission of HIV is the leading cause of pediatric AIDS; however, mechanisms by which HIV compromises pregnancy are not understood. CD4+CD25+ T-regulatory (Treg) cells play a role in pregnancy maintenance. RNA from early and late gestation placentas and fetuses from FIV-infected and control cats were probed for expression of FIV gag and Treg markers CD25, FOXP3, and CTLA4, using real time reverse-transcriptase (RT)-PCR. High rates of vertical transmission and reproductive failure were detected in early and late pregnancy. In control animals, both FOXP3 and CTLA4 expression decreased with gestational stage, indicating a natural decline in Tregs. Expression of FOXP3 and CTLA4 was decreased at early gestation in FIV-infected queens and a trend toward decreased expression of CD25, FOXP3, and CTLA4 in placentas from FIV-infected queens producing non-viable pregnancies was observed as well. Our results suggest that FIV infection may alter placental Treg function and adversely affect pregnancy outcome.
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