Hannover, Universiẗat, Diss., 2003.

Jod ist ein essentielles Spurenelement, welches der Mensch zur Aufrechterhaltung des ungestörten Schilddrüsenmetabolismus und davon beeinflussten verschiedenen Körperfunktionen benötigt. Weltweit gab und gibt es einen Jodmangel, der schwerwiegende gesundheitliche Folgen für das Individuum und wirtschaftliche Folgen für die Gesundheitssysteme des jeweiligen Landes hat. Auch Deutschland galt mit weiteren europäischen Ländern bis vor wenigen Jahren als Jodmangelgebiet. Durch intensive Aufklärungsarbeit und Programme zur Beseitigung des Jodmangels gelang es, diesen in vielen Ländern zu vermindern. Außer einer generellen Verwendung von Jodsalz in der Lebensmittelproduktion und den Privathaushalten, konnten noch weitere wichtige Jodquellen für die Bevölkerung in verschiedenen Studien belegt werden. Diese Studie beschäftigt sich mit der Ermittlung von Jodgehalt in Alltagsgetränken. Die Ergebnisse sind vergleichbar zu bereits veröffentlichen Studien und zeigen einen hohen Jodgehalt von Milch und Milchgetränken, sowie von Bier und Wein. Kein Jod in größeren Mengen hingegen enthält das regionale Leitungswasser, sowie Mineralwässer und diverse Fruchtsäfte. Somit kann der Verzehr von Milch und Milchgetränken und in Maßen auch Bier und Wein für eine jodreiche Ernährung empfohlen werden. Hingegen sollten Patienten in Vorbereitung zum Beispiel auf eine Radiojodtherapie Milch, Biere und Wein eher meiden und jodarme Getränke bevorzugen. / Iodine is an essential trace element, which is required to maintain the undisturbed thyroid metabolism. It influences various body functions. Worldwide there is a lack of iodine which has serious health consequences for the individual. There are also economic consequences for the health systems of each country. A few years ago Germany was, with other European countries,a iodine deficiency area. With intensive educational work and programs for the elimination of iodine deficiency, it was possible to reduce the iodine deficiency in many countries. A general use of iodized salt in the food production and households, other important sources of iodine could be found in various studies. This study deals with the determination of iodine content in everyday drinks. The results are comparable to previously published studies and show a high iodine content of milk and milk-based drinks, as well as beer and wine. No iodine in larger amounts, however, contains the local tap water, mineral water and various fruit juices. The consumption of milk, milk-based drinks, beer and wine in moderation can be recommended for an iodine-rich diet. In contrast, patients in preparation for a radioiodine therapie shoud avoid milk, beer and wine.

Giessen, Veterinär-med. Diss. v. 25. Mai 1914, Ref. Geppert. / [Geb. 18. Aug. 86 Rotenburg a. d. Fulda ; Wohnort : Giessen ; Staatsangeh. : Preussen ; Vorbildung : G. Fulda Reife 08 ; Studium : Theol. Fulda theol.-phil. Fak. 3, Tierheilk. Giessen 7 S. ; Rig. 6. März 14.].

Hannover, Universiẗat, Diss., 1998.

Techn. Universiẗat, Diss., 2005--München.

Zugl.: Bremen, Univ., Diss., 2006

Universiẗat, Diss., 2001--Stuttgart. / Erscheinungsjahr an der Haupttitelstelle: 2001.

Universiẗat, Diss., 2004--München.

The chemistry of fluorolkyl hypervalent iodine reagents has witnessed a great boast in recent years. These compounds are highly attractive as drug candidates, advanced materials and agrochemicals as described in detail in the Introduction. Despite this fact, applications of these reagents in biological studies are rather rare and under developed. The goal of this thesis is therefore the development of mild and metal-free methods in order to fill this gap. Two ways of application of fluoroalkyl hypervalent iodine reagents in labeling of biologically relevant compounds was explored. First, the applicability of previously reported parent Togni CF3 and their analogous tetrafluoroethyl reagents in radical fluoroalkylation of electron-rich substrates such as indole and pyrrole derivatives using sodium ascorbate as reductant was described. This afforded trifluoromethyl or 1,1,2,2-tetrafluoroethyl containing products in moderate to high yields. Next, same reagents were applied for labeling of several peptides and proteins bearing aromatic amino acids in their structure. This way, peptides and proteins containing electron-rich aromatics such as Trp, Phe, Tyr and His were reacted with fluoroalkyl groups with high selectivity toward Trp. In the second part of the work, a different approach of radical...

The Indian Summer Monsoon (ISM) plays a vital role in the livelihoods and economy of those living on the Indian subcontinent, including the small, mountainous country of Bhutan. The ISM fluctuates over varying temporal scales and its variability is related to many internal and external factors including the El Niño Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD). In 2015, a Super El Niño occurred in the tropical Pacific alongside a positive IOD in the Indian Ocean and was followed in 2016 by a simultaneous La Niña and negative IOD. These events had worldwide repercussions. However, it is unclear how the ISM was affected during this time, both at a regional scale over the whole ISM area and at a local scale over Bhutan. First, an evaluation of data products comparing ERA5 reanalysis, TRMM and GPM satellite, and GPCC precipitation products against weather station measurements from Bhutan, showed that ERA5 reanalysis was the most suitable product to investigate ISM change in these two years. Using the reanalysis datasets, it was shown that there was disruption to the ISM during this period, with a late onset of the monsoon in 2015, a shifted monsoon flow in July 2015 and in August 2016 and a late withdrawal in 2016. However, this resulted in neither a monsoon surplus nor deficit across both years but instead large spatial-temporal variability. It is possible to attribute some of the regional scale changes to the ENSO and IOD events, but the expected impact of a simultaneous ENSO and IOD events are not recognisable. This may be due to a supposed weakening of the ENSO/ISM relationship and it is likely that 2015/16 monsoon disruption was driven by a combination of factors alongside ENSO and the IOD, including varying boundary conditions, the Pacific Decadal Oscillation, the Atlantic Multi-decadal Oscillation, and more. At a local scale, the intricate topography and orographic processes ongoing within Bhutan further amplified or dampened the already altered ISM. Whilst ENSO and IOD driven monsoon variability can be recognised at a regional scale, a direct link between ENSO and IOD activity and changes to the monsoon at a local scale over Bhutan is hard to distinguish. It is unknown how the ISM, ENSO, and the IOD will evolve under a future changing climate and therefore this presents a concern to Bhutan with its inherent vulnerability to monsoon variability.