The fluctuation of the world economy has a tremendous influence to domestic imports and exports to a small opened economy. In another word, it has great impact to the current account of a small opened economy. After the 1980s, Taiwan relies on the growth of net export to drive its economy growth, showing that depend on to foreign trade degree quite high, so government values the current account very much. With the economic variables of the region of America, Asia, and Europe to carry on regional study the relation with the current account of Taiwan, the relevant parameter included in this research is that foreign production value, domestic production value, real effective of exchange rate, and real interest rate differential of domestic and international. Utilize structural vector autoregressive model, with impulse response functions and forecast error variance decompositions analysis result, to consider each variable in short-run and long-run to the current account of influence. According to impulse response functions, it synthesizes three regional analysis results, the current account accord with the theories with the relevant parameter. The foreign production value increases to cause the current account increment. The domestic production value increases to cause the current account reduced and converge in the long-run. The real effective of exchange rate increases to cause the current account surplus in the short-run, the impulsive effect is convergence in the long-run. The real interest rate differential increases to cause the current account deficit in the short-run. According to forecast error variance decompositions, the current account is influence by the real effective of exchange rate and itself factor in three regions, in addition the influence by the foreign production value in the region of America and Asia. In the region of America and Asia, the current account receives self influence that decreases progressively at time changes that part substitutes by the foreign production value. Under the long-run, the foreign production value in the region of America and Asia is also influence by the current account because imports and exports of Taiwan are in the majority that the main country comes from America and Asia, that the production value of regions are easier to cause the current account. The current account always causes by the real effective of exchange rate in the long-run. Accord with Shirvani and Wilbratte (1997), the real exchange rate has the long-run relational with the current account in real example analysis. In the short-run, the exchange rate depreciation has not influenced the result to the current account. In the long-run, the depreciation can improve the current account to become surplus. This research discovers to influence the factor of the current account of Taiwan, in the region of America and Asia, the foreign production value makes the phenomenon with the current account surplus in the long-run. In the region of American, Asia, and Europe, the real effective of exchange rate increases to make the phenomenon with the current account surplus in the long-run, the current account receives self influence no matter under short-run and long-run. In the short-run, the influence of the current account results negative direction and oscillation to convergence.

The tripartite motif (TRIM) family comprises at least 80 members in humans, with most having ubiquitin or SUMO E3 ligase activity conferred by their N-terminal RING domain. TRIMs regulate a wide range of processes in ubiquitination-or sumoylation-dependent manners in most cases, and fewer as adaptors. Their roles in the regulation of viral infections, autophagy, cell cycle progression, DNA damage and other stress responses, and carcinogenesis are being increasingly appreciated, and their E3 ligase activities are attractive targets for developing specific immunother-apeutic strategies for immune diseases and cancers. Given their importance in antiviral immune response, viruses have evolved sophisticated immune escape strategies to subvert TRIM-mediated mechanisms. In this review, we focus on their regulation of IFN-I-mediated innate immune response, which plays key roles in antiviral and antitumor defense.

Made available in DSpace on 2017-07-10T17:11:44Z (GMT). No. of bitstreams: 1 DISSERTACAO OSCAR SCUSSEL.pdf: 4301786 bytes, checksum: 8a64e99e73bc5e4478b9e5077d78baed (MD5) Previous issue date: 2013-03-04 / Impulse Response Functions (IRFs) are important in many engineering applications, mainly in structural dynamics and modal analysis involving experimental modal tests. These IRFs can be identified through several methods. Among these, the classical covariance method is one of the most used and it is based on the sum of convolution from the correlation functions between input and output signals known. However, this method is limited because it employs a large number of samples and has drawbacks related to over parametrization. In this sense, this work presentes and review the covariance method expanded in the ortonormal basis Kautz functions, because this alternative way allows to avoid these drawbacks. In order to ilustrate the procedure an algorithm with multiple objective functions to obtain the optimal poles of the Kautz filter is shown. The results are provided through three degree-of-freedom mechanical system simulated and experimental data in a beam to show the advantages, drawbacks, simplicity and efficiency of the proposed approach. / As funções de resposta ao impulso (IRFs) exercem papel de destaque na identificação de sistemas reais quando têm-se o conhecimento dos dados de entrada/saída do sistema. Essas IRFs são relevantes em muitas aplicações de Engenharia, especialmente em análise modal experimental de estruturas. Dentre os métodos para obtenção dessas IRFs, destaca-se o clássico método das covariâncias baseado na soma de convolução das funções de correlação entre os sinais de entrada e saída conhecidos. No entanto, esse método é limitado quando são coletadas muitas amostras e possui algumas desvantagens como efeitos de sobreparametrização. Neste sentido, este trabalho apresenta e revisa o método das covariâncias expandido na base ortonormal de Kautz para aplicações em identificação de sistemas mecânicos, pois essa forma alternativa permite evitar esses efeitos de sobreparametrização. Para obter os pólos ótimos dos filtros de Kautz, emprega-se um algoritmo multi-objetivo. Os resultados são verificados através de um sistema mecânico com três graus de liberdade e em dados experimentais a partir de uma viga na condição livre-livre no qual verificam-se as vantagens, desvantagens, simplicidade e eficiência do método proposto.

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