Gradually, the physical and geographically restricted marketplace is eroding and giving room to a more vibrant and competitive virtual marketplace – J.F Rayport and J.J Sviokla referred to it as the ―marketspace‖ (J.F. Payport, 1995). Technological advancement is the causative agent of this rapid change. As customers become increasingly complex and find sustained satisfaction in the marketspace, pressure keeps mounting on enterprises to adjust and seek suitable dance to the new rhythm. More prepared enterprises like e-bay and FEDEX have taken advantage of this rapid change to emerge competitive in the marketspace whist others dawdle behind. Enterprises especially in developing economies like Ghana, are increasingly investing enterprise resources in IT infrastructure, and accompanying applications and services to take advantage of the new marketplace and emerge competitive nationally and perhaps, in the process, gain global competitiveness. Are firms having strategic frameworks that guide these investments? And what are the factors that influence the adoption of these frameworks? Are there enabling national and firm level mechanisms to support IT investments? These are the questions that the research seeks to respond to. The research discovered Ghana’s strategic initiatives aimed at providing enabling infrastructure, regulatory and business environment to support the adoption of ICTs into public and civil service, and to also promote the performance and competitiveness of its industries and firms. At firm level, the research investigated the factors that influence the adaptation and effective implementation of IT Governance frameworks in enterprises. The research found education, external business environment, and extent of IT investment, statistically significant in driving IT process and governance framework adoption. It was therefore, recommended that regulatory institutions, educational institutions, market players and managers of firms contribute to the enhancement of these predictor variables to further improve ICT, IT process and IT governance framework adoption in Ghana. It was also recommended that later research should be undertaken to re-evaluate the performance and progress made by Ghanaian firms, and to possibly discover other drivers of ICT, ITprocess and IT governance framework adoption. / IT Process and Governance framework adoption in Ghana is relatively new. The research identifies Education, Level of IT investment and the Business Environment to be the most influential factors in promoting IT process and governance framework adoption in Ghana. / +233-246655744 / +233 - 201111216