Global ETD Search

31	Detekce povrchového fenotypu a chemosenzitivity buněk nádorů močového měchýře in vitro / Detection of surface phenotype and chemosensitivity in bladder carcinoma cells in vitro Šímová, Michaela January 2021 (has links) Tumor malignancies are the second leading cause of death worldwide. One of the reasons for the failure of oncological treatment are the uniformly set clinical guidelines, which neglect the effect of high intertumoral heterogeneity. The in vitro chemosensitivity and resistance (CSRA) assays allow for the stratification of patients prior to therapy. Therefore, the CSRA are a long-considered method for personalization of components of chemotherapy regime. Nevertheless, none of them is being routinely used in clinical practice. Certain chemotherapeutics used for their cytotoxic and cytostatic effect are also able to induce so-called immunogenic cell death (ICD) of tumor cells and activate an anti-tumor immune response. Monitoring of changes in the expression of molecules associated with the regulation of the innate immune system on the surface of dying tumor cells would enable to predict the patient's ability to respond to treatment involving modern immunotherapeutics. The feasibility of CSRA using flow cytometry and microscopy is critically evaluated in this thesis on a model of bladder cancer. Simultaneously, the correlation of the immunogenic phenotype of tumor cells and their sensitivity to selected chemotherapeutics is discussed.
32	The Roles of the Phosphatases of Regenerating Liver (PRLs) in Oncology and Normal Physiology Frederick Georges Bernard Nguele Meke (16671573) 03 August 2023 (has links) <p> </p> <p>The phosphatases of regenerating liver are a subfamily of protein tyrosine phosphatases that consist of PRL1, PRL2 and PRL3. The overexpression of PRLs promote cell proliferation, migration and invasion and contribute to tumorigenesis and metastasis to aggravate survival outcome. Although there is increasing interest in understanding the implication of these phosphatases in tumor development, currently, limited knowledge is available about their mechanism of action and the efficacy of PRL inhibition in <em>in vivo</em> tumor models, the tumor extrinsic role of PRLs that allow them to impact tumor development, as well as <em>in vivo</em> physiological function of PRLs that could implicate them in diseases other than cancer. The work presented here aims to address these limitations.</p> <p><br></p> Signal transduction Tumour immunology Haematological tumours Solid tumours Phosphatase of regenerating liver Tp53 PTEN tumor microenviroment (TME) tumor immunogenic microenvironment tumor vasculature formation T cell activation Dendritic cell Obesity mitochondrial function-related genes Tp53 deficiency mouse models syngeneic MC38 mouse model

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Detekce povrchového fenotypu a chemosenzitivity buněk nádorů močového měchýře in vitro / Detection of surface phenotype and chemosensitivity in bladder carcinoma cells in vitro

The Roles of the Phosphatases of Regenerating Liver (PRLs) in Oncology and Normal Physiology