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Molecular epidemiology of H9N2 avian influenza virus in poultry of southern ChinaButt, Ka-man, Carmen. January 2005 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.
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Identification of Mutations in the NS1 Gene That Control Influenza A Virus Virulence in the Mouse ModelDankar, Samar 03 October 2012 (has links)
The genetic requirements for Influenza virus to infect and adapt to new species is largely unknown. To understand the evolutionary steps required by a virus to become virulent, a human virus (A/HK/1/68) (HK), avirulent in mice, was subjected to 20 and 21 serial lung-to-lung passages in mouse. Sequence analysis revealed the emergence of eleven mutations within the NS1 gene of the new virulent strains, many of which occurred in binding sites for transcriptional and translational cellular factors. In the present study we have rescued viruses containing each of the NS1 mouse adapted mutations onto A/PR/8/34 (PR8) backbone. We found 9 of 16 NS1 mutants were adaptive by inducing mortality, body weight loss in BALB/c mice and enhanced virus replication in MDCK cells with properties of host cell interferon transcription inhibition. Sequence comparisons with the highly pathogenic A/Hong Kong/156/1997 (H5N1) and the most severe pandemic A/Brevig Mission/1/1918 (H1N1) NS1 genes showed convergent evolution with some of the mouse adapted viruses for F103L plus M106I and V226I plus R227K mutations respectively. The F103L and M106I mutations in the HK NS1 gene were shown to be adaptive by assessment with respect to replication, early viral protein synthesis, interferon-β antagonism and tropism in the mouse lung. We extended the study and proved increased virulence associated with F103L+M106I mutations in their respective H5N1 NS1 gene on the PR8 and HK backbones, as well as the PR8 NS1 gene and the H9N2 (A/Ck/Bj/1/95) gene in the PR8 and A/WSN/33 backbones respectively. However the V226I and R227K mutations in their respective HK and 1918 NS1 genes slightly enhanced virulence and viral growth at later stages of infection. This study demonstrates that NS1 is a virulence factor; involved in multiple viral processes including interferon antagonism and viral protein synthesis. Furthermore, NS1 mutations acquired during mouse adaptation are proven to be adaptive in human, mouse and avian NS1 genes.
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Study of the host factors interacting with H5N1 influenza virus /Wang, Pui, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 174-194). Also available online.
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Role of a distinct PA gene for the pathogenicity and replication properties of avian H5N1 influenza virus in miceQin, Kun, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 169-186). Also available in print.
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Role of a distinct PA gene for the pathogenicity and replication properties of avian H5N1 influenza virus in mice /Qin, Kun, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 169-186). Also available online.
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Study of the host factors interacting with H5N1 influenza virusWang, Pui, January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 174-194). Also available in print.
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Interactions of human natural killer cells with the hemagglutinin froman H5N1 influenza virusXia, Zhengyun., 夏正耘. January 2010 (has links)
published_or_final_version / Microbiology / Master / Master of Philosophy
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Study of the host factors interacting with H5N1 influenza virusWang, Pui, 王培 January 2009 (has links)
published_or_final_version / Microbiology / Doctoral / Doctor of Philosophy
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The role of mannose binding lectin in influenza virus infectionLing, Man-to., 凌文韜. January 2009 (has links)
published_or_final_version / Paediatrics and Adolescent Medicine / Master / Master of Philosophy
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Development of a high-throughput screening platform to identify small molecule inhibitors targeting influenza A virusTsui, Heung-wing, Wayne, 徐向榮 January 2006 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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