The assignment of genetic factors to definite loci in the hereditary mechanism has been a great step in the progress of biology. Of the cereal crops, barley (Hordeum sp.), a crop of economic importance, offers a superior opportunity for genetic studies. Its adaptation to wide varieties of conditions, with a wealth of easily differentiated characters and only seven pairs of chromosomes, the barley plant provides excellent material for linkage studies. Although there is a vast amount of literature dealing with inheritance in barley, yet knowledge of the subject is still very limited. The mode of inheritance of about one hundred characters has been studied and linkage relations of nearly thirty-five characters have been made. The location of a relatively large number of them is still unknown. All the seven linkage groups are established and distinct viable characters are available in six of them, although but few in some cases. The desirability of making further studies in this crop is quite apparent. This manuscript contains the results of observations and experiments with sixteen characters which include three new characters not reported in the literature. All character pairs in each cross studied were checked for possible linkages or independence. The importance of such a study in the future improvement of the barley crop needs no emphasis.

In light of the current opioid epidemic, the past 20 years have made it clear that parental life experiences can significantly impact the behavior and neurobiology of their offspring. Preclinical studies indicate that addiction reflects the interaction of an individual’s environment, genetics, and epigenetic modifications they inherit from their parents. Epigenetic mechanisms - including DNA methylation, histone modification, and small non-coding RNAs – refer to the complex interaction between genes and the environment, which produce heritable changes in germ cells that are transmitted to offspring to ultimately influence the brain development and subsequent vulnerability to develop a substance use disorder. The overarching goal of this dissertation was to characterize the behavioral and neurobiological effects of paternal morphine exposure on addiction-related endpoints in offspring. A highly translational rodent model of paternal morphine self-administration was used to produce first-generation (F1) male and female adolescent and adult offspring. As a reference, offspring derived from morphine-exposed fathers were called morphine-sired offspring, and offspring from saline-exposed fathers were called saline-sired offspring. In chapter 2, we revealed that male morphine-sired progeny are more sensitive over time to the pain-relieving effects of morphine. In the periaqueductal grey, an important pain-related brain region, we identified gene expression changes in regulators of G-protein signaling proteins that could partly account for this phenotype. In chapter 3, we demonstrated that adult morphine-sired male offspring self-administered more morphine; were more motived to earn morphine infusions compared to controls; and had more baseline mu-opioid receptor binding in the ventral tegmental area. Next, in chapter 4, we found that a drug-abstinence period of 90 consecutive days following 60 days of morphine exposure in sires was sufficient to prevent morphine-sired males from self-administering more morphine than controls. In chapter 5, we showed that this addiction-like phenotype did not extend to adolescent male or female offspring. Lastly, in chapter 6, using the incubation of craving paradigm, we found that paternal morphine exposure significantly reduced cue-induced active lever pressing for heroin in morphine-sired males. Taken together, these results add to the growing body of literature that show paternal preconception experiences can impact behavioral and neurobiological endpoints in offspring, perhaps via a(n) epigenetically inherited mechanism(s) in the germline. / Psychology

Information exchanged between computer applications is difficult, thus the need for data exchange standards. The ISO STEP project defines data exchange standards using the EXPRESS language, which supports inheritance. Currently there are two algorithms used to evaluate an inheritance hierarchy: the Test and Generate algorithms. In this thesis, enhancements are made to both algorithms to support the Total Over Constraint, which is proposed for the third edition of EXPRESS. A formal algorithm is derived for the Test algorithm. The two enhanced algorithms are compared and shown to be result equivalent. However, it is shown that the Test algorithm is the more efficient of the two.

Historically, organizational structures of many universities and corporations have followed a strictly tree-based, hierarchical model. These organizations are defined with no more than one parent organization, and typically resource requirements for the organization could be derived from the parent organization. In recent years, however, many institutions have created interdisciplinary research groups which incorporate multiple fields of research across multiple campus organizations. For example, at Brigham Young University, there exists a biophysics research group, a child organization of both the Department of Biology and the Department of Physics, making it unclear how to define its resource requirements in the context of multiple parents from diverse colleges. As computing resources are allocated to organizations, the requirements of those organizations must be taken into account. However, when organizations have multiple parent organizations, it is unclear which restrictions or allocations are appropriate for the organization, as shown with the biophysics research group described above. Extending the example, if a campus high-performance computing facility restricts resources on an organizational basis, and the Biology and Physics departments are allocated different resource levels, the newly formed biophysics group will need system administrators' intervention to assure appropriate resource allocation. This document describes a versatile system for modeling organizational structure, including defining multiple parent organizations, the inheritance of arbitrary properties from parent to children, and, when inherited attributes conflict, includes an extensible mechanism for defining conflict resolution policies. This system allows for arbitrary parameters to be applied at any level of the organizational structure. This inherited information can then be used for resource allocation of the campus high performance computing facility.

<p> Paul, the author of Gal 3:23-4:7 and Rom 8:14-25, demonstrates in these two passages a new thing for all believers in Christ-a clear movement from slavery to adoption as sons to the status of heirs. This movement occurs through the process of adoption into God's family and is characterized by inclusiveness regardless of race, socioeconomic status, or gender. This study will explore the promise that the marginalized can participate in a full, new creation inheritance. According to the promise of Rom 4:13, the dispossessed will "inherit the world." This concept of the new creation so clearly seen in Rom 8-expressed also as inheriting the world in Rom 4:13-is critical for correctly interpreting Gal 3:28, framed as it is in a discussion of inheritance and adoption. For this reason, it is of great benefit to study Gal 3:23-4:7 and Rom 8:14-25 together.</p> / Thesis / Master of Theological Studies (MTS)

<p> Popular theories about the origin of life can be classified to two classes: metabolism first or genes first. As a metabolism first theory, the lipid world theory, in which non-covalent assemblies of lipids, such as micelles and vesicles store information in the form of a non-random molecular composition, has been proposed to investigate the possibility of inheritance without genes. Our models assume that interaction occurs between nearest neighbour molecules only, and account for spatial segregation of molecules of different types within the assembly. We also draw a distinction between a self-assembly model, in which the composition is determined by mutually favourable interaction energies between the molecules, and a catalytic model, in which the composition is determined by mutually favourable catalysis. We show that compositional inheritance occurs in both models, although the self-assembly case seems more relevant if the molecules are simple lipids. In the case where the assemblies are composed of just two types of molecules, there is a strong analogy with the classic two-allele Moran model from population genetics. This highlights the parallel between compositional inheritance and genetic inheritance. We also investigated the polymerization reactions which may bridge the gap between simple organic molecules and the beginning of the RNA world, which belongs to the class of genes first theories. We found that different from normal chemical systems, catalysts for the polymerization system can shift the equilibrium toward longer polymers. Together with RNA's potential as catalyst, the RNA polymerization system may form a feedback loop which makes the formation of functional RNA molecules easier, and come more close to the beginning of RNA world.</p> / Thesis / Master of Science (MSc)

In the majority of sexual eukaryotes, mitochondria are inherited predominantly from a single, usually the female, parent Like the majority of higher plants and animals, the pathogenic yeast Cryptococcus neoformans has two mating types (sexes), however, these two sexes are morphologically similar. In this study, I examined the distribution of the mating types and how mating types influence the inheritance of mitochondria in C. neoformans. My survey of mating type alleles in 358 isolates collected from four geographic areas in the US showed a biased distribution of mating type alleles with most isolates containing mating type a alleles. To characterize the role of mating type locus on mitochondrial inheritance, I constructed two pairs of congenic strains that differed only at the mitochondrial genome and mating type locus. Mating between these two pairs of strains demonstrated that uniparental inheritance in C. neoformans was controlled by the mating type locus and progeny predominantly inherited mitochondria from the mating type a parent. Specifically, we identified two genes within the mating type locus, SXIIa in mating type a strain and SXI2a in mating type a strain, that control mitochondrial inheritance. Disruption of these two genes resulted in biparental mitochondrial inheritance in sexual crosses. These two genes are the first ones identified capable of controlling uniparental mitochondrial inheritance in any organism. In addition, we determined that the deletion of the SXIIa gene enhanced the spread of mitochondrial introns in sexual crosses. This discovery is consistent with the hypothesis that uniparental lnheritance might have evolved to prevent the spread of selfish cytoplasmic elements. / Thesis / Doctor of Philosophy (PhD)

The Notre Dame Bay Magmatic Province (NDBMP) comprises a suite of Late Jurassic (Tithonian), rift-related alkaline mafic intrusions in north-central Newfoundland, Canada. This field-based study focuses on the Leading Tickles area, where the gabbroic Budgell’s Harbour Stock (BHS) and radial lamprophyre dykes intrude strongly folded and faulted Ordovician back-arc volcanic and sedimentary host rocks. The primary objective was to understand how pre-existing structures influenced the emplacement and post-intrusion deformation of the NDBMP. This thesis employs a comprehensive methodology, including field mapping, thin section analysis, stereographic projections, kinematic and dynamic analysis, GIS visualization, and 3D analog modelling to analyze the interactions between pre-existing structures and the NDBMP. The results reveal that lamprophyres preferentially exploited pre-existing Paleozoic Appalachian structures associated with the Iapetus Suture Zone. Furthermore, magmatic activity weakened and deformed the host rocks, leading to the reactivation of Silurian thrust faults that deformed the lamprophyres post-intrusion. Movement along Luke’s Arm Fault Zone (LAFZ) in Leading Tickles may indicate a broader reactivation of the Iapetus Suture in northern Newfoundland during the Mesozoic. The variation in lamprophyre mineralogies and the presence of numerous radial dyke clusters suggest multiple magma sources coinciding with regional antiforms. / Thesis / Master of Science (MSc) / The Notre Dame Bay Magmatic Province (NDBMP) in north-central Newfoundland features Late Jurassic alkaline mafic intrusions linked to rifting. This study examines the Leading Tickles area, where gabbroic intrusions and lamprophyre dykes intersect older Ordovician rocks. The research explores how existing geological structures influenced the placement and deformation of these magmatic bodies. Using fieldwork, microscopic analysis, and 3D modeling, the study shows that ancient Appalachian structures guided the intrusion paths, and post-intrusion fault reactivations further deformed the rocks. The findings suggest multiple magma sources and broader regional tectonic movements during the Mesozoic.

This study is designed to analyze and compare the private annuity and installment sale transaction from an estate planning perspective. This comparison is to be made in the environment of gifting and other likely assumptions. The research is broken into three separate parts. The first portion is a careful examination of the tax aspects of both transactions. The second portion is the discussion and documentation of the models themselves. The third portion is a discussion of the output, its implications and a comparison of both techniques. The 1976 Tax Reform Act caused definite changes in the areas of estate planning; these changes required planners to look at other techniques to accomplish what had once been done with gifting. This study looks at the private annuity and installment sale transaction in that light. A private annuity is a sale, generally between family members, of property in return for a fixed payment for the remainder of the life of the transferor. An installment sale is now the method used for reporting gain on a sale where the payment extends further than the current tax year. Both of these methods may be used to transfer property prior to death as estate planning techniques. A comparison of both alternatives shows that generally the private annuity is more favorable for a younger transferor or one with a shorter expected life. The installment sale is generally more favorable for an older transferor with a longer expected life. All the planning methods were more favorable than doing nothing and the model shows an optimal point for gifting dependent upon the unified credit. The study shows promise for quantification in the area of taxation. The research would have been impossible if the large data base could not have been generated through use of computer simulation of the transactions. As the technology becomes more available the use of quantification techniques similar to those utilized in this study will increase.

- Evolution of inheritance titles My thesis contains the description and analysis of inheritance titles through the history - from Roman law to legal situation de lege ferenda. The institution of inheritance is an indispensable part of the system of law. The inheritance contributes to keeping property values of a deceased person for his successors, usually for further generations. The inheritance law contributes also to the certainty and continuity in legal relations between entities of civil law relations. The topic of this thesis are inheritance titles, which represent legal grounds of inheritance. The thesis pays the greatest deal of attention to the regulation de lege lata and regulation de lege ferenda and their comparation. Description of the provisions of the civil code is accompanied by important judgments of the courts. Historical excursion starts in the Roman law which is commonly accepted as the basis of the current legal regulations and follows by the brief review of the middle-ages law. The thesis then deals with the Allgemeines bürgerliches Gesetzbuch (ABGB) adopted in 1811. This civil code became the first modern regulation in the Czech territory. ABGB was valid until the beginning of the twentieth century's 50s, after the communist revolution, when new "socialistic" regulation took...