Global ETD Search

21	Strategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonists Sheldrake, Helen M., Patterson, Laurence H. 2014 February 1925 (has links) Yes / The integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer and associated conditions; thrombosis, angiogenesis and osteoporosis. The most reported strategy for drug development is synthesis of an agent that is highly selective for a single integrin receptor. However, the ability of cancer cells to change their integrin repertoire in response to drug treatment renders this approach vulnerable to the development of resistance and paradoxical promotion of tumor growth. Here, we review progress towards development of antagonists targeting two or more members of the RGD-binding integrins, notably αvβ3, αvβ5, αvβ6, αvβ8, α5β1, and αIIbβ3, as anticancer therapeutics. Integrins RGD-binding integrins Cancer Development of antagonists Anticancer therapeutics
22	FAK and Pyk2 regulate the intracellular signaling networks required for integrin-mediated migration and phagocytosis by macrophages Owen, Katherine Anne. January 2007 (has links) Thesis (Ph. D.)--University of Virginia, 2008. / Title from title page. Includes bibliographical references. Also available online through Digital Dissertations.
23	Important role of tetraspanin CD81 in integrin-dependent retinal phagocytosis / Chang, Yongen. January 2007 (has links) Thesis (Ph. D.)--Cornell University, May, 2007. / Vita. Includes bibliographical references (leaves 120-133).
24	Structural interactions between the a3b1 integrin and mmp-2 : a potential functional role in cell adhesion / Bowman, James Russell, January 1900 (has links) Thesis (Ph.D.)--Virginia Commonwealth University, 2009. / Prepared for: Dept. of Anatomy and Neurobiology. Title from title-page of electronic thesis. Bibliography: leaves 175-196.
25	Extracellular matrix receptors in astrogliosis Vincent-Héroux, Jonathan, January 1900 (has links) Thesis (M.Sc.). / Written for the Dept. of Biology. Title from title page of PDF (viewed 2009/13/07). Includes bibliographical references.
26	Regulation of human T helper cell differentiation by the combined action of accessory molecules and cytokines / Palmer, Ellen Marie. January 2000 (has links) Thesis (Ph. D.)--University of Chicago, Pritzer School of Medicine, Committee on Immunology, June 2000. / Includes bibliographical references. Also available on the Internet. T cells Integrins. Interleukin-12.
27	Serine phosphorylation of the carboxyl terminus of focal adhesion kinase / Ma, Amy. January 2000 (has links) Thesis (Ph. D.)--University of Virginia, 2000. / Spine title: Serine phosphorylation of FAK. Includes bibliographical references (p. 209-231). Also available online through Digital Dissertations.
28	ADAMs in cell adhesion and migration / Huang, Jing. January 2005 (has links) Thesis (Ph. D.)--University of Virginia, 2005. / Includes bibliographical references (leaves 158-161). Also available online through Digital Dissertations. ADAM Proteins Integrins Cell Movement
29	Structural investigation of the complex of filamin a repeat 21 with integrin aIIb & ß₃ cytoplasmic tails a potential "transmission" to regulate cell migration / Liu, Jianmin. January 2009 (has links) Thesis (Ph.D.)--Cleveland State University, 2009. / Abstract. Title from PDF t.p. (viewed on Feb. 1, 2010). Includes bibliographical references (p. 104-114). Available online via the OhioLINK ETD Center and also available in print.
30	A mathematical model of adhesion interactions between living cells / Johnson, Casey P., January 2005 (has links) (PDF) Thesis (M.S.)--Brigham Young University. Dept. of Mathematics, 2005. / Includes bibliographical references (p. 56).

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